p53-independent upregulation of p21 super(WAF1) in NIH 3T3 cells malignantly transformed by mot-2

Mot-2 protein is shown to interact with p53 and inhibit its transcriptional activation function. Mot-2 overexpressing stable clones of NIH 3T3 cells were malignantly transformed, however, they had a high level of expression of a p53 downstream gene, p21 super(WAF1). The present study was undertaken...

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Veröffentlicht in:	Cell research 2001-03, Vol.11 (1), p.55-60
Hauptverfasser:	TAKANO, Syuichi, WADHWA, Renu, MITSUI, Youji, KAUL, Sunil C
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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