Treatment of glioblastoma with poly(isohexyl cyanoacrylate) nanoparticles

Glioblastomas belong to the most devastating cancer diseases. For this reason, polysorbate 80 (Tween 80 ®)-coated poly(isohexyl cyanoacrylate) (PIHCA) (Monorex ®) nanoparticles loaded with doxorubicin were developed and tested for their use for the treatment of glioblastomas. The preparation of the...

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Veröffentlicht in:	International journal of pharmaceutics 2011-08, Vol.415 (1), p.244-251
Hauptverfasser:	Wohlfart, Stefanie, Khalansky, Alexander S., Bernreuther, Christian, Michaelis, Martin, Cinatl, Jindrich, Glatzel, Markus, Kreuter, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - drug therapy Brain Neoplasms - pathology Buffers Cancer Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects cell viability Cyanoacrylates - chemistry Doxorubicin Doxorubicin - administration & dosage Doxorubicin - therapeutic use Drug Carriers - chemistry Drug Compounding Glial fibrillary acidic protein Glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Histology humans Immunohistochemistry Immunosuppressive agents inhibitory concentration 50 Male Microscopy, Electron, Scanning Nanoparticles Nanoparticles - chemistry neoplasms Particle Size Physicochemical properties Poly(isohexyl cyanoacrylate) polysorbates Rats Rats, Wistar Solubility Surface Properties therapeutics Toxicity Xenograft Model Antitumor Assays
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