Diagnostic applications for inhibin and activins
► Diagnostic value of inhibin and activin measurements were evaluated. ► Inhibin A enhances diagnosis of Down syndrome in second trimester pregnancy. ► Total inhibin is a marker of certain forms of ovarian cancer. ► Inhibin B is useful in male infertility. ► Other applications remain unclear. Inhibi...
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| Veröffentlicht in: | Molecular and cellular endocrinology 2012-08, Vol.359 (1-2), p.121-125 |
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| creator | McNeilly, Alan S. |
| description | ► Diagnostic value of inhibin and activin measurements were evaluated. ► Inhibin A enhances diagnosis of Down syndrome in second trimester pregnancy. ► Total inhibin is a marker of certain forms of ovarian cancer. ► Inhibin B is useful in male infertility. ► Other applications remain unclear.
Inhibin and activins play major roles as paracrine and autocrine signaling molecules in reproduction and development where the main emphasis has been placed in developing potential diagnostic applications. While a role for activin assays in diagnostics has so far been unfounded, ELISAs specific for the biologically active inhibin A and B dimers, and for free inhibin alpha subunits, alone or in combination have found some specific diagnostic applications. Addition of inhibin A to the triple test for Down syndrome in the second trimester of pregnancy, measurement of total inhibin as a marker of certain forms of ovarian cancer in specific circumstances, and inhibin B for male fertility are useful diagnostics. A review of the evidence so far suggests that other applications for inhibin and activin assays have yet to be confirmed, or translated into reliable tools for clinical practice. |
| doi_str_mv | 10.1016/j.mce.2011.06.017 |
| format | Article |
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Inhibin and activins play major roles as paracrine and autocrine signaling molecules in reproduction and development where the main emphasis has been placed in developing potential diagnostic applications. While a role for activin assays in diagnostics has so far been unfounded, ELISAs specific for the biologically active inhibin A and B dimers, and for free inhibin alpha subunits, alone or in combination have found some specific diagnostic applications. Addition of inhibin A to the triple test for Down syndrome in the second trimester of pregnancy, measurement of total inhibin as a marker of certain forms of ovarian cancer in specific circumstances, and inhibin B for male fertility are useful diagnostics. A review of the evidence so far suggests that other applications for inhibin and activin assays have yet to be confirmed, or translated into reliable tools for clinical practice.</description><identifier>ISSN: 0303-7207</identifier><identifier>EISSN: 1872-8057</identifier><identifier>DOI: 10.1016/j.mce.2011.06.017</identifier><identifier>PMID: 21741437</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Activin ; activins ; Activins - blood ; Activins - metabolism ; animal ovaries ; Animals ; Assaying ; Biomarkers - blood ; Biomarkers - metabolism ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - metabolism ; Diagnostic applications ; Diagnostic software ; diagnostic techniques ; Dimers ; Down syndrome ; ELISA ; enzyme-linked immunosorbent assay ; Female ; Fertility ; Humans ; Infertility, Female - blood ; Infertility, Female - diagnosis ; inhibin ; Inhibin A ; Inhibin B ; Inhibins - blood ; Inhibins - metabolism ; Male ; male fertility ; Males ; Markers ; ovarian neoplasms ; Ovarian Neoplasms - blood ; Ovarian Neoplasms - diagnosis ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - diagnosis ; Pregnancy ; Reproduction ; Reproductive disorders ; Spermatogenesis</subject><ispartof>Molecular and cellular endocrinology, 2012-08, Vol.359 (1-2), p.121-125</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-c9773175f342dde488074ea573e51d90939a59a286757a994e098a1c2f36698d3</citedby><cites>FETCH-LOGICAL-c410t-c9773175f342dde488074ea573e51d90939a59a286757a994e098a1c2f36698d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mce.2011.06.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21741437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McNeilly, Alan S.</creatorcontrib><title>Diagnostic applications for inhibin and activins</title><title>Molecular and cellular endocrinology</title><addtitle>Mol Cell Endocrinol</addtitle><description>► Diagnostic value of inhibin and activin measurements were evaluated. ► Inhibin A enhances diagnosis of Down syndrome in second trimester pregnancy. ► Total inhibin is a marker of certain forms of ovarian cancer. ► Inhibin B is useful in male infertility. ► Other applications remain unclear.
Inhibin and activins play major roles as paracrine and autocrine signaling molecules in reproduction and development where the main emphasis has been placed in developing potential diagnostic applications. While a role for activin assays in diagnostics has so far been unfounded, ELISAs specific for the biologically active inhibin A and B dimers, and for free inhibin alpha subunits, alone or in combination have found some specific diagnostic applications. Addition of inhibin A to the triple test for Down syndrome in the second trimester of pregnancy, measurement of total inhibin as a marker of certain forms of ovarian cancer in specific circumstances, and inhibin B for male fertility are useful diagnostics. A review of the evidence so far suggests that other applications for inhibin and activin assays have yet to be confirmed, or translated into reliable tools for clinical practice.</description><subject>Activin</subject><subject>activins</subject><subject>Activins - blood</subject><subject>Activins - metabolism</subject><subject>animal ovaries</subject><subject>Animals</subject><subject>Assaying</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - metabolism</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Diagnostic applications</subject><subject>Diagnostic software</subject><subject>diagnostic techniques</subject><subject>Dimers</subject><subject>Down syndrome</subject><subject>ELISA</subject><subject>enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Fertility</subject><subject>Humans</subject><subject>Infertility, Female - blood</subject><subject>Infertility, Female - diagnosis</subject><subject>inhibin</subject><subject>Inhibin A</subject><subject>Inhibin B</subject><subject>Inhibins - blood</subject><subject>Inhibins - metabolism</subject><subject>Male</subject><subject>male fertility</subject><subject>Males</subject><subject>Markers</subject><subject>ovarian neoplasms</subject><subject>Ovarian Neoplasms - blood</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - diagnosis</subject><subject>Pregnancy</subject><subject>Reproduction</subject><subject>Reproductive disorders</subject><subject>Spermatogenesis</subject><issn>0303-7207</issn><issn>1872-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0MFOGzEQBmCrApWU9gF6oXvsZZcZe-2xxQmFllZC4tBythyvNzhKdoO9QeLt6ygpR8RpLt_8M_oZ-4rQIKC6XDUbHxoOiA2oBpA-sBlq4rUGSSdsBgJETRzojH3KeQUAJLn-yM44UoutoBmDm-iWw5in6Cu33a6jd1Mch1z1Y6ri8BgXcajc0FXOT_E5DvkzO-3dOocvx3nOHn7--Dv_Vd_d3_6eX9_VvkWYam-IBJLsRcu7LrRaA7XBSRJBYmfACOOkcVwrkuSMaQMY7dDzXihldCfO2fdD7jaNT7uQJ7uJ2Yf12g1h3GWLIDRvjRT0DopaCeRkCsUD9WnMOYXeblPcuPRS0N4pu7KlU7vv1IKypdOyc3GM3y02oXvd-F9iAd8OoHejdcsUs334UxIklMMIai-uDiKUxp5jSDb7GAYfupiCn2w3xjce-AdfJ40k</recordid><startdate>20120815</startdate><enddate>20120815</enddate><creator>McNeilly, Alan S.</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20120815</creationdate><title>Diagnostic applications for inhibin and activins</title><author>McNeilly, Alan S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-c9773175f342dde488074ea573e51d90939a59a286757a994e098a1c2f36698d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Activin</topic><topic>activins</topic><topic>Activins - blood</topic><topic>Activins - metabolism</topic><topic>animal ovaries</topic><topic>Animals</topic><topic>Assaying</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - metabolism</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Diagnostic applications</topic><topic>Diagnostic software</topic><topic>diagnostic techniques</topic><topic>Dimers</topic><topic>Down syndrome</topic><topic>ELISA</topic><topic>enzyme-linked immunosorbent assay</topic><topic>Female</topic><topic>Fertility</topic><topic>Humans</topic><topic>Infertility, Female - blood</topic><topic>Infertility, Female - diagnosis</topic><topic>inhibin</topic><topic>Inhibin A</topic><topic>Inhibin B</topic><topic>Inhibins - blood</topic><topic>Inhibins - metabolism</topic><topic>Male</topic><topic>male fertility</topic><topic>Males</topic><topic>Markers</topic><topic>ovarian neoplasms</topic><topic>Ovarian Neoplasms - blood</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Polycystic Ovary Syndrome - 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Inhibin and activins play major roles as paracrine and autocrine signaling molecules in reproduction and development where the main emphasis has been placed in developing potential diagnostic applications. While a role for activin assays in diagnostics has so far been unfounded, ELISAs specific for the biologically active inhibin A and B dimers, and for free inhibin alpha subunits, alone or in combination have found some specific diagnostic applications. Addition of inhibin A to the triple test for Down syndrome in the second trimester of pregnancy, measurement of total inhibin as a marker of certain forms of ovarian cancer in specific circumstances, and inhibin B for male fertility are useful diagnostics. A review of the evidence so far suggests that other applications for inhibin and activin assays have yet to be confirmed, or translated into reliable tools for clinical practice.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21741437</pmid><doi>10.1016/j.mce.2011.06.017</doi><tpages>5</tpages></addata></record> |
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| subjects | Activin activins Activins - blood Activins - metabolism animal ovaries Animals Assaying Biomarkers - blood Biomarkers - metabolism Biomarkers, Tumor - blood Biomarkers, Tumor - metabolism Diagnostic applications Diagnostic software diagnostic techniques Dimers Down syndrome ELISA enzyme-linked immunosorbent assay Female Fertility Humans Infertility, Female - blood Infertility, Female - diagnosis inhibin Inhibin A Inhibin B Inhibins - blood Inhibins - metabolism Male male fertility Males Markers ovarian neoplasms Ovarian Neoplasms - blood Ovarian Neoplasms - diagnosis Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - diagnosis Pregnancy Reproduction Reproductive disorders Spermatogenesis |
| title | Diagnostic applications for inhibin and activins |
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