A novel molecularly imprinted electrochemiluminescence sensor for isoniazid detection

Based on Ru(bpy) 3 2+ -Au nanoparticles decorated multi-walled carbon nanotubes composites and a molecularly imprinted polymer (MIP), we propose a novel molecularly imprinted electrochemiluminescence (ECL) sensor to selectively determine isoniazid (INH). The MIP is synthesized through electrochemical copolymerization of acrylamide and N , N -methylene diacrylamide in the presence of INH template molecules. The enhanced ECL intensity is linear in the range of 0.1 to 110 g cm 3 and the detection limit is 0.08 g cm 3 (3 ) INH with relative standard deviation 3.8% ( n = 6) for 8 g cm 3 . As a result, the sensor has been successfully applied to the determination of INH in human urine and pharmaceutical samples. Moreover, the possible ECL mechanism is discussed. A novel molecularly imprinted electrochemiluminescence sensor to directly determine isoniazid in real samples was proposed based on Ru-AuNP-MCNT composites.