Soft fibrin gels promote selection and growth of tumorigenic cells

The identification of stem-cell-like cancer cells through conventional methods that depend on stem cell markers is often unreliable. We developed a mechanical method for selecting tumorigenic cells by culturing single cancer cells in fibrin matrices of ~100 Pa in stiffness. When cultured within thes...

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Veröffentlicht in:	Nature materials 2012-08, Vol.11 (8), p.734-741
Hauptverfasser:	Liu, Jing, Tan, Youhua, Zhang, Huafeng, Zhang, Yi, Xu, Pingwei, Chen, Junwei, Poh, Yeh-Chuin, Tang, Ke, Wang, Ning, Huang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 639/301/54 Animals Biomarkers Biomaterials Biotechnology Cancer Cell Separation - methods Cell Survival Condensed Matter Physics Fibrin Gels Human Humans Injection Lungs Markers Materials Science Melanoma, Experimental - pathology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Mice, SCID Nanotechnology Neoplastic Stem Cells Optical and Electronic Materials Spheroids, Cellular Stem cells Stiffness Tumor Cells, Cultured Tumors Tumours
Online-Zugang:	Volltext
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