Mono and dialkoxysilane surface modification of superparamagnetic iron oxide nanoparticles for application as magnetic resonance imaging contrast agents
In this study, we have developed and characterized two previously unstudied alkoxysilane surface chemistries for use with superparamagnetic iron oxide (SPIO) nanoparticles as a magnetic resonance imaging contrast agent. We modified superparamagnetic iron oxide nanoparticles (SPIO) using aminopropyl...
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| Veröffentlicht in: | Journal of materials research 2012-07, Vol.27 (14), p.1846-1852 |
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| creator | Larsen, Brian A. Hurst, Kendall M. Ashurst, W. Robert Serkova, Natalie J. Stoldt, Conrad R. |
| description | In this study, we have developed and characterized two previously unstudied alkoxysilane surface chemistries for use with superparamagnetic iron oxide (SPIO) nanoparticles as a magnetic resonance imaging contrast agent. We modified superparamagnetic iron oxide nanoparticles (SPIO) using aminopropyl triethoxysilane and two analogous alkoxysilanes, aminopropyl dimethylethoxysilane and aminopropyl methyldiethoxysilane, to compare a mono- and dialkoxysilane, respectively, to a more commonly used trialkoxysilane as two new SPIO surface chemistries capable of forming ultrathin functional surface coatings. The ligand densities of the mono- and dialkoxysilane-modified SPIO produced in this study are consistent with near monolayers of ligands on the SPIO surface. We studied the chemical stability of the mono-, di-, and trialkoxysilane-modified SPIO in neutral and acidic media to evaluate the viability of these surface chemistries for use in long-term intracellular applications. The mono- and dialkoxysilane-modified SPIO demonstrate comparable chemical stability to the trialkoxysilane-modified SPIO, indicating that the mono- and dialkoxysilane are both viable new SPIO surface chemistries for future applications requiring minimally thick alkoxysilane surface coatings. |
| doi_str_mv | 10.1557/jmr.2012.160 |
| format | Article |
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Robert ; Serkova, Natalie J. ; Stoldt, Conrad R.</creator><creatorcontrib>Larsen, Brian A. ; Hurst, Kendall M. ; Ashurst, W. Robert ; Serkova, Natalie J. ; Stoldt, Conrad R.</creatorcontrib><description>In this study, we have developed and characterized two previously unstudied alkoxysilane surface chemistries for use with superparamagnetic iron oxide (SPIO) nanoparticles as a magnetic resonance imaging contrast agent. We modified superparamagnetic iron oxide nanoparticles (SPIO) using aminopropyl triethoxysilane and two analogous alkoxysilanes, aminopropyl dimethylethoxysilane and aminopropyl methyldiethoxysilane, to compare a mono- and dialkoxysilane, respectively, to a more commonly used trialkoxysilane as two new SPIO surface chemistries capable of forming ultrathin functional surface coatings. The ligand densities of the mono- and dialkoxysilane-modified SPIO produced in this study are consistent with near monolayers of ligands on the SPIO surface. We studied the chemical stability of the mono-, di-, and trialkoxysilane-modified SPIO in neutral and acidic media to evaluate the viability of these surface chemistries for use in long-term intracellular applications. The mono- and dialkoxysilane-modified SPIO demonstrate comparable chemical stability to the trialkoxysilane-modified SPIO, indicating that the mono- and dialkoxysilane are both viable new SPIO surface chemistries for future applications requiring minimally thick alkoxysilane surface coatings.</description><identifier>ISSN: 0884-2914</identifier><identifier>EISSN: 2044-5326</identifier><identifier>DOI: 10.1557/jmr.2012.160</identifier><identifier>CODEN: JMREEE</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Acids ; Applied and Technical Physics ; Biomaterials ; Contrast agents ; Fourier transforms ; Inorganic Chemistry ; Iron oxides ; Ligands ; Magnetic resonance imaging ; Materials Engineering ; Materials research ; Materials Science ; Nanoparticles ; Nanotechnology ; NMR ; Nuclear magnetic resonance ; Protective coatings ; Spectrum analysis ; Studies</subject><ispartof>Journal of materials research, 2012-07, Vol.27 (14), p.1846-1852</ispartof><rights>Copyright © Materials Research Society 2012</rights><rights>The Materials Research Society 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-20836cc2e5cec6bdc34a6d9b5f60b71e06fc5738139a4847309b0bbe6850bf393</citedby><cites>FETCH-LOGICAL-c373t-20836cc2e5cec6bdc34a6d9b5f60b71e06fc5738139a4847309b0bbe6850bf393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1557/jmr.2012.160$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0884291412001604/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,41464,42533,51294,55603</link.rule.ids></links><search><creatorcontrib>Larsen, Brian A.</creatorcontrib><creatorcontrib>Hurst, Kendall M.</creatorcontrib><creatorcontrib>Ashurst, W. Robert</creatorcontrib><creatorcontrib>Serkova, Natalie J.</creatorcontrib><creatorcontrib>Stoldt, Conrad R.</creatorcontrib><title>Mono and dialkoxysilane surface modification of superparamagnetic iron oxide nanoparticles for application as magnetic resonance imaging contrast agents</title><title>Journal of materials research</title><addtitle>Journal of Materials Research</addtitle><description>In this study, we have developed and characterized two previously unstudied alkoxysilane surface chemistries for use with superparamagnetic iron oxide (SPIO) nanoparticles as a magnetic resonance imaging contrast agent. We modified superparamagnetic iron oxide nanoparticles (SPIO) using aminopropyl triethoxysilane and two analogous alkoxysilanes, aminopropyl dimethylethoxysilane and aminopropyl methyldiethoxysilane, to compare a mono- and dialkoxysilane, respectively, to a more commonly used trialkoxysilane as two new SPIO surface chemistries capable of forming ultrathin functional surface coatings. The ligand densities of the mono- and dialkoxysilane-modified SPIO produced in this study are consistent with near monolayers of ligands on the SPIO surface. We studied the chemical stability of the mono-, di-, and trialkoxysilane-modified SPIO in neutral and acidic media to evaluate the viability of these surface chemistries for use in long-term intracellular applications. The mono- and dialkoxysilane-modified SPIO demonstrate comparable chemical stability to the trialkoxysilane-modified SPIO, indicating that the mono- and dialkoxysilane are both viable new SPIO surface chemistries for future applications requiring minimally thick alkoxysilane surface coatings.</description><subject>Acids</subject><subject>Applied and Technical Physics</subject><subject>Biomaterials</subject><subject>Contrast agents</subject><subject>Fourier transforms</subject><subject>Inorganic Chemistry</subject><subject>Iron oxides</subject><subject>Ligands</subject><subject>Magnetic resonance imaging</subject><subject>Materials Engineering</subject><subject>Materials research</subject><subject>Materials Science</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Protective coatings</subject><subject>Spectrum analysis</subject><subject>Studies</subject><issn>0884-2914</issn><issn>2044-5326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqFkUuLFDEUhYM4YDvjzh8QcOPCavOsx1IGXzDiZmZd3ErdFGmrkjKphpl_4s_1Nj2KiOAqcO53Tm5yGHspxV5a27w9LHmvhFR7WYsnbKeEMZXVqn7KdqJtTaU6aZ6x56UchJBWNGbHfnxJMXGIIx8DzN_S_UMJM0Tk5Zg9OORLGoMPDraQIk-e9BXzChkWmCJuwfGQT5P7MCKPEBPNSJ2xcJ8yh3Wdf7mh8N-mjCURTRcE0kKcuEtxy1A2DhPGrVyxCw9zwReP5yW7-_D-9vpTdfP14-frdzeV043eKiVaXTun0Dp09TA6baAeu8H6WgyNRFF7ZxvdSt2BaU2jRTeIYcC6tWLwutOX7PU5d83p-xHL1i-hOJxPn5COpZdCt0oroxShr_5CD-mYI21HFBFNJ6wk6s2ZcjmVktH3a6Y35geC-lNNPdXUn2rqqSbCqzNeCIsT5j9D_8nvH-NhGXIYJ_yP4Sfx7qeq</recordid><startdate>20120728</startdate><enddate>20120728</enddate><creator>Larsen, Brian A.</creator><creator>Hurst, Kendall M.</creator><creator>Ashurst, W. 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Robert ; Serkova, Natalie J. ; Stoldt, Conrad R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-20836cc2e5cec6bdc34a6d9b5f60b71e06fc5738139a4847309b0bbe6850bf393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acids</topic><topic>Applied and Technical Physics</topic><topic>Biomaterials</topic><topic>Contrast agents</topic><topic>Fourier transforms</topic><topic>Inorganic Chemistry</topic><topic>Iron oxides</topic><topic>Ligands</topic><topic>Magnetic resonance imaging</topic><topic>Materials Engineering</topic><topic>Materials research</topic><topic>Materials Science</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Protective coatings</topic><topic>Spectrum analysis</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Larsen, Brian A.</creatorcontrib><creatorcontrib>Hurst, Kendall M.</creatorcontrib><creatorcontrib>Ashurst, W. 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Robert</au><au>Serkova, Natalie J.</au><au>Stoldt, Conrad R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mono and dialkoxysilane surface modification of superparamagnetic iron oxide nanoparticles for application as magnetic resonance imaging contrast agents</atitle><jtitle>Journal of materials research</jtitle><stitle>Journal of Materials Research</stitle><date>2012-07-28</date><risdate>2012</risdate><volume>27</volume><issue>14</issue><spage>1846</spage><epage>1852</epage><pages>1846-1852</pages><issn>0884-2914</issn><eissn>2044-5326</eissn><coden>JMREEE</coden><abstract>In this study, we have developed and characterized two previously unstudied alkoxysilane surface chemistries for use with superparamagnetic iron oxide (SPIO) nanoparticles as a magnetic resonance imaging contrast agent. We modified superparamagnetic iron oxide nanoparticles (SPIO) using aminopropyl triethoxysilane and two analogous alkoxysilanes, aminopropyl dimethylethoxysilane and aminopropyl methyldiethoxysilane, to compare a mono- and dialkoxysilane, respectively, to a more commonly used trialkoxysilane as two new SPIO surface chemistries capable of forming ultrathin functional surface coatings. The ligand densities of the mono- and dialkoxysilane-modified SPIO produced in this study are consistent with near monolayers of ligands on the SPIO surface. We studied the chemical stability of the mono-, di-, and trialkoxysilane-modified SPIO in neutral and acidic media to evaluate the viability of these surface chemistries for use in long-term intracellular applications. The mono- and dialkoxysilane-modified SPIO demonstrate comparable chemical stability to the trialkoxysilane-modified SPIO, indicating that the mono- and dialkoxysilane are both viable new SPIO surface chemistries for future applications requiring minimally thick alkoxysilane surface coatings.</abstract><cop>New York, USA</cop><pub>Cambridge University Press</pub><doi>10.1557/jmr.2012.160</doi><tpages>7</tpages></addata></record> |
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| subjects | Acids Applied and Technical Physics Biomaterials Contrast agents Fourier transforms Inorganic Chemistry Iron oxides Ligands Magnetic resonance imaging Materials Engineering Materials research Materials Science Nanoparticles Nanotechnology NMR Nuclear magnetic resonance Protective coatings Spectrum analysis Studies |
| title | Mono and dialkoxysilane surface modification of superparamagnetic iron oxide nanoparticles for application as magnetic resonance imaging contrast agents |
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