The majority of CD1d‐sulfatide‐specific T cells in human blood use a semiinvariant Vδ1 TCR

αβ T‐cell lines specific for sulfatide, an abundant myelin glycosphingolipid presented by various CD1 molecules, have been previously derived from PBMCs of patients with demyelinating diseases such as multiple sclerosis (MS) but also from healthy subjects. Using an unbiased tetramer‐based MACS enric...

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Veröffentlicht in:	European journal of immunology 2012-09, Vol.42 (9), p.2505-2510
Hauptverfasser:	Bai, Li, Picard, Damien, Anderson, Brian, Chaudhary, Vinod, Luoma, Adrienne, Jabri, Bana, Adams, Erin J., Savage, Paul B., Bendelac, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens - immunology Antigens, CD1d - immunology CD1 Epitopes, T-Lymphocyte - immunology Gamma delta T cell Genes, MHC Class I - immunology Humans Lipid Multiple Sclerosis - immunology Receptors, Antigen, T-Cell, gamma-delta - immunology Sulfatide Sulfoglycosphingolipids - immunology T-Lymphocytes - immunology TCR
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