Transporter-Mediated Drug-Drug Interactions Involving OATP Substrates: Predictions Based on In Vitro Inhibition Studies

Transporter‐mediated drug–drug interactions (DDIs) are among the most important of the clinically relevant pharmacokinetic DDIs. We investigated the validity of a static prediction of area under the plasma concentration–time curve (AUC) ratios (AUCRs; AUCwith inhibitor/AUCcontrol) using in vitro inh...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2012-06, Vol.91 (6), p.1053-1064
Hauptverfasser:	Yoshida, K, Maeda, K, Sugiyama, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Area Under Curve Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism Cytoplasmic Vesicles - enzymology Cytoplasmic Vesicles - metabolism Dogs Drug Interactions Enzymes - metabolism Forecasting HEK293 Cells Humans Kidney - metabolism Kinetics Liver - enzymology Medical sciences Microsomes, Liver - enzymology Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - metabolism Pharmaceutical Preparations - blood Pharmaceutical Preparations - metabolism Pharmacokinetics Pharmacology. Drug treatments
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