Membrane Affinity and Antibacterial Properties of Cationic Polyelectrolytes With Different Hydrophobicity
The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged li...
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| Veröffentlicht in: | Macromolecular bioscience 2012-09, Vol.12 (9), p.1181-1189 |
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| creator | Kiss, Éva Heine, Elisabeth T. Hill, Katalin He, Ying Chun Keusgen, Nina Pénzes, Csanád B. Schnöller, Donát Gyulai, Gergő Mendrek, Aleksandra Keul, Helmut Moeller, Martin |
| description | The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged lipids. The polymer/lipid interaction results in structural changes of the penetrated lipid layer visualized using AFM. The polymers are found to be effective in inhibiting the proliferation of E. coli, B. subtilis and S. aureus. The influence of the chemical structure on the functional behavior is related to the conformational properties. An optimum structure is identified on the basis of antibacterial and hemolytic tests as well as membrane‐destroying efficacy of the antimicrobial polymers.
The antibacterial behavior of cationic polyelectrolytes is studied. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers. The polymers are found to be effective in inhibiting proliferation of E. coli, B. subtilis and S. aureus. An optimum structure is identified on the basis of antibacterial and hemolytic tests. |
| doi_str_mv | 10.1002/mabi.201200078 |
| format | Article |
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The antibacterial behavior of cationic polyelectrolytes is studied. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers. The polymers are found to be effective in inhibiting proliferation of E. coli, B. subtilis and S. aureus. An optimum structure is identified on the basis of antibacterial and hemolytic tests.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.201200078</identifier><identifier>PMID: 22833349</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; antimicrobial properties ; Applied sciences ; Bacillus subtilis - drug effects ; Biological properties ; Cations ; Electrolytes - chemistry ; Electrolytes - pharmacology ; Escherichia coli - drug effects ; Exact sciences and technology ; functional polymers ; Hemolysis - drug effects ; membrane affinity ; Membrane Lipids - chemistry ; Microscopy, Atomic Force ; Organic polymers ; Physicochemistry of polymers ; poly(ethylene imine)s ; polyamphiphiles ; Properties and characterization ; Spectrometry, Fluorescence ; Staphylococcus aureus - drug effects ; Surface Tension ; Thermodynamics</subject><ispartof>Macromolecular bioscience, 2012-09, Vol.12 (9), p.1181-1189</ispartof><rights>Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4138-2a79f088a6f4d17eb5a4980f8b79287c8cad31741504f0832a48f256115dc6623</citedby><cites>FETCH-LOGICAL-c4138-2a79f088a6f4d17eb5a4980f8b79287c8cad31741504f0832a48f256115dc6623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmabi.201200078$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmabi.201200078$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26389481$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22833349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiss, Éva</creatorcontrib><creatorcontrib>Heine, Elisabeth T.</creatorcontrib><creatorcontrib>Hill, Katalin</creatorcontrib><creatorcontrib>He, Ying Chun</creatorcontrib><creatorcontrib>Keusgen, Nina</creatorcontrib><creatorcontrib>Pénzes, Csanád B.</creatorcontrib><creatorcontrib>Schnöller, Donát</creatorcontrib><creatorcontrib>Gyulai, Gergő</creatorcontrib><creatorcontrib>Mendrek, Aleksandra</creatorcontrib><creatorcontrib>Keul, Helmut</creatorcontrib><creatorcontrib>Moeller, Martin</creatorcontrib><title>Membrane Affinity and Antibacterial Properties of Cationic Polyelectrolytes With Different Hydrophobicity</title><title>Macromolecular bioscience</title><addtitle>Macromol. Biosci</addtitle><description>The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged lipids. The polymer/lipid interaction results in structural changes of the penetrated lipid layer visualized using AFM. The polymers are found to be effective in inhibiting the proliferation of E. coli, B. subtilis and S. aureus. The influence of the chemical structure on the functional behavior is related to the conformational properties. An optimum structure is identified on the basis of antibacterial and hemolytic tests as well as membrane‐destroying efficacy of the antimicrobial polymers.
The antibacterial behavior of cationic polyelectrolytes is studied. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers. The polymers are found to be effective in inhibiting proliferation of E. coli, B. subtilis and S. aureus. An optimum structure is identified on the basis of antibacterial and hemolytic tests.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antimicrobial properties</subject><subject>Applied sciences</subject><subject>Bacillus subtilis - drug effects</subject><subject>Biological properties</subject><subject>Cations</subject><subject>Electrolytes - chemistry</subject><subject>Electrolytes - pharmacology</subject><subject>Escherichia coli - drug effects</subject><subject>Exact sciences and technology</subject><subject>functional polymers</subject><subject>Hemolysis - drug effects</subject><subject>membrane affinity</subject><subject>Membrane Lipids - chemistry</subject><subject>Microscopy, Atomic Force</subject><subject>Organic polymers</subject><subject>Physicochemistry of polymers</subject><subject>poly(ethylene imine)s</subject><subject>polyamphiphiles</subject><subject>Properties and characterization</subject><subject>Spectrometry, Fluorescence</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Surface Tension</subject><subject>Thermodynamics</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPGzEURi1EVSh0yxJ5g9TNpH6NH8uQtoAEJYtU6c7yeGxhOo9gO2rn39coadpdV76Sz_f5-gBwgdEMI0Q-9qYJM4IwQQgJeQROMce8qrGqjw-zFCfgXUrPCGEhFXkLTgiRlFKmTkF4cH0TzeDg3PswhDxBM7RwPuTQGJtdDKaDyzhuXMzBJTh6uDA5jEOwcDl2k-uczbEMuVyuQ36Cn4L3Lrohw9upLcGnsQm29J6DN950yb3fn2fg25fPq8Vtdf94c7eY31eWYSorYoTySErDPWuxcE1tmJLIy0YoIoWV1rQUC4ZrxApHiWHSk5pjXLeWc0LPwIdd7yaOL1uXsu5Dsq7ryifHbdIYUUkIJ4oXdLZDbRxTis7rTQy9iVOB9Kte_apXH_SWwOW-e9v0rj3gf3wW4GoPmGRN54tZG9JfjlOpmMSFUzvuZ-jc9J9n9cP8-u7fJapdNqTsfh2yJv7QXFBR6_XXG33N1t9XK7HUNf0N0C6jaQ</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Kiss, Éva</creator><creator>Heine, Elisabeth T.</creator><creator>Hill, Katalin</creator><creator>He, Ying Chun</creator><creator>Keusgen, Nina</creator><creator>Pénzes, Csanád B.</creator><creator>Schnöller, Donát</creator><creator>Gyulai, Gergő</creator><creator>Mendrek, Aleksandra</creator><creator>Keul, Helmut</creator><creator>Moeller, Martin</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley-VCH</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>Membrane Affinity and Antibacterial Properties of Cationic Polyelectrolytes With Different Hydrophobicity</title><author>Kiss, Éva ; Heine, Elisabeth T. ; Hill, Katalin ; He, Ying Chun ; Keusgen, Nina ; Pénzes, Csanád B. ; Schnöller, Donát ; Gyulai, Gergő ; Mendrek, Aleksandra ; Keul, Helmut ; Moeller, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4138-2a79f088a6f4d17eb5a4980f8b79287c8cad31741504f0832a48f256115dc6623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antimicrobial properties</topic><topic>Applied sciences</topic><topic>Bacillus subtilis - drug effects</topic><topic>Biological properties</topic><topic>Cations</topic><topic>Electrolytes - chemistry</topic><topic>Electrolytes - pharmacology</topic><topic>Escherichia coli - drug effects</topic><topic>Exact sciences and technology</topic><topic>functional polymers</topic><topic>Hemolysis - drug effects</topic><topic>membrane affinity</topic><topic>Membrane Lipids - chemistry</topic><topic>Microscopy, Atomic Force</topic><topic>Organic polymers</topic><topic>Physicochemistry of polymers</topic><topic>poly(ethylene imine)s</topic><topic>polyamphiphiles</topic><topic>Properties and characterization</topic><topic>Spectrometry, Fluorescence</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Surface Tension</topic><topic>Thermodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiss, Éva</creatorcontrib><creatorcontrib>Heine, Elisabeth T.</creatorcontrib><creatorcontrib>Hill, Katalin</creatorcontrib><creatorcontrib>He, Ying Chun</creatorcontrib><creatorcontrib>Keusgen, Nina</creatorcontrib><creatorcontrib>Pénzes, Csanád B.</creatorcontrib><creatorcontrib>Schnöller, Donát</creatorcontrib><creatorcontrib>Gyulai, Gergő</creatorcontrib><creatorcontrib>Mendrek, Aleksandra</creatorcontrib><creatorcontrib>Keul, Helmut</creatorcontrib><creatorcontrib>Moeller, Martin</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiss, Éva</au><au>Heine, Elisabeth T.</au><au>Hill, Katalin</au><au>He, Ying Chun</au><au>Keusgen, Nina</au><au>Pénzes, Csanád B.</au><au>Schnöller, Donát</au><au>Gyulai, Gergő</au><au>Mendrek, Aleksandra</au><au>Keul, Helmut</au><au>Moeller, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Membrane Affinity and Antibacterial Properties of Cationic Polyelectrolytes With Different Hydrophobicity</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol. Biosci</addtitle><date>2012-09</date><risdate>2012</risdate><volume>12</volume><issue>9</issue><spage>1181</spage><epage>1189</epage><pages>1181-1189</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>The antibacterial behavior of cationic polyelectrolytes is studied using model membrane experiments and in vitro bacterial investigations. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers of neutral or negatively charged lipids. The polymer/lipid interaction results in structural changes of the penetrated lipid layer visualized using AFM. The polymers are found to be effective in inhibiting the proliferation of E. coli, B. subtilis and S. aureus. The influence of the chemical structure on the functional behavior is related to the conformational properties. An optimum structure is identified on the basis of antibacterial and hemolytic tests as well as membrane‐destroying efficacy of the antimicrobial polymers.
The antibacterial behavior of cationic polyelectrolytes is studied. The molecular interaction with lipid films is evaluated by the degree of penetration of the polymers into Langmuir monolayers. The polymers are found to be effective in inhibiting proliferation of E. coli, B. subtilis and S. aureus. An optimum structure is identified on the basis of antibacterial and hemolytic tests.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>22833349</pmid><doi>10.1002/mabi.201200078</doi><tpages>9</tpages></addata></record> |
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| ispartof | Macromolecular bioscience, 2012-09, Vol.12 (9), p.1181-1189 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antimicrobial properties Applied sciences Bacillus subtilis - drug effects Biological properties Cations Electrolytes - chemistry Electrolytes - pharmacology Escherichia coli - drug effects Exact sciences and technology functional polymers Hemolysis - drug effects membrane affinity Membrane Lipids - chemistry Microscopy, Atomic Force Organic polymers Physicochemistry of polymers poly(ethylene imine)s polyamphiphiles Properties and characterization Spectrometry, Fluorescence Staphylococcus aureus - drug effects Surface Tension Thermodynamics |
| title | Membrane Affinity and Antibacterial Properties of Cationic Polyelectrolytes With Different Hydrophobicity |
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