Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers
The aim of the study was to assess the proportions of 'high-risk' drinkers' abstinent or with 'low-risk' consumption levels 1 year after the initiation of high-dose baclofen. This is a retrospective 'open' study; the outcome of this study was to assess the level of...
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| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 2012-07, Vol.47 (4), p.439-442 |
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| container_title | Alcohol and alcoholism (Oxford) |
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| creator | Rigal, Laurent Alexandre-Dubroeucq, Constance de Beaurepaire, Renaud Le Jeunne, Claire Jaury, Philippe |
| description | The aim of the study was to assess the proportions of 'high-risk' drinkers' abstinent or with 'low-risk' consumption levels 1 year after the initiation of high-dose baclofen.
This is a retrospective 'open' study; the outcome of this study was to assess the level of alcohol consumption in the 12th month of treatment.
Of the 181 patients included, a follow-up evaluation was possible in 132 patients. The initial alcohol consumption of the 132 patients analysed averaged 182 ± 92 g/day. After 1 year, 80% of the 132 (i.e. 58% of 181) were either abstinent (n = 78) or drinking at low-risk levels (n = 28) in their 12th month of treatment. The mean baclofen dose at 1 year was 129 ± 71 mg/day.
High-dose baclofen should be tested in randomized placebo-controlled trials among high-risk drinkers. |
| doi_str_mv | 10.1093/alcalc/ags028 |
| format | Article |
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This is a retrospective 'open' study; the outcome of this study was to assess the level of alcohol consumption in the 12th month of treatment.
Of the 181 patients included, a follow-up evaluation was possible in 132 patients. The initial alcohol consumption of the 132 patients analysed averaged 182 ± 92 g/day. After 1 year, 80% of the 132 (i.e. 58% of 181) were either abstinent (n = 78) or drinking at low-risk levels (n = 28) in their 12th month of treatment. The mean baclofen dose at 1 year was 129 ± 71 mg/day.
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This is a retrospective 'open' study; the outcome of this study was to assess the level of alcohol consumption in the 12th month of treatment.
Of the 181 patients included, a follow-up evaluation was possible in 132 patients. The initial alcohol consumption of the 132 patients analysed averaged 182 ± 92 g/day. After 1 year, 80% of the 132 (i.e. 58% of 181) were either abstinent (n = 78) or drinking at low-risk levels (n = 28) in their 12th month of treatment. The mean baclofen dose at 1 year was 129 ± 71 mg/day.
High-dose baclofen should be tested in randomized placebo-controlled trials among high-risk drinkers.</description><subject>Adult</subject><subject>Alcohol</subject><subject>Alcohol consumption</subject><subject>Alcohol Drinking - drug therapy</subject><subject>alcoholism</subject><subject>Alcoholism - drug therapy</subject><subject>Baclofen - therapeutic use</subject><subject>Clinical trials</subject><subject>Consumption</subject><subject>Dosage</subject><subject>Female</subject><subject>GABA-B Receptor Agonists - therapeutic use</subject><subject>High risk</subject><subject>Humans</subject><subject>Initiation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Sexual behavior</subject><subject>Temperance - statistics & numerical data</subject><issn>0735-0414</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkT9v2zAQxYkiRe0mGbsG3NxFNf9KVDbDaNICBrq0s0CTJ5uNRDoklcAfod-6SuRkNvCAG-5373D3EPpCyTdKar7UnRm11LtEmPqA5lSUouCSsAs0JxWXBRFUzNDnlP4SQgVn9BOaMSa4KEsxR_9W25SdB28Aa2_xogvPRXTpYYFN8GnoD9kFjyk-go5YtxkiznvAzrvs9GsvtHjvdvvChgR4q00XWvC3WOMIOYZ0AJPdE-CUB3vEug9-hxevA9MaG51_gJiu0MdWdwmuT_US_bn7_nv9o9j8uv-5Xm0Kw2uViwoohVIoZTnwUlSklG1FtZUMBEgqt1QQQ6Rkun05V1GijC7J-BViraA1v0RfJ99DDI8DpNz0LhnoOu0hDKmhZByipFL8DJSpUbWU56CMyZozNaLFhJrxOylC2xyi63U8jlDzkmkzZdpMmY78zcl62PZg3-m3EPl_wLOdxg</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Rigal, Laurent</creator><creator>Alexandre-Dubroeucq, Constance</creator><creator>de Beaurepaire, Renaud</creator><creator>Le Jeunne, Claire</creator><creator>Jaury, Philippe</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7QJ</scope></search><sort><creationdate>201207</creationdate><title>Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers</title><author>Rigal, Laurent ; 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This is a retrospective 'open' study; the outcome of this study was to assess the level of alcohol consumption in the 12th month of treatment.
Of the 181 patients included, a follow-up evaluation was possible in 132 patients. The initial alcohol consumption of the 132 patients analysed averaged 182 ± 92 g/day. After 1 year, 80% of the 132 (i.e. 58% of 181) were either abstinent (n = 78) or drinking at low-risk levels (n = 28) in their 12th month of treatment. The mean baclofen dose at 1 year was 129 ± 71 mg/day.
High-dose baclofen should be tested in randomized placebo-controlled trials among high-risk drinkers.</abstract><cop>England</cop><pmid>22434664</pmid><doi>10.1093/alcalc/ags028</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Alcohol and alcoholism (Oxford), 2012-07, Vol.47 (4), p.439-442 |
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| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Alcohol Alcohol consumption Alcohol Drinking - drug therapy alcoholism Alcoholism - drug therapy Baclofen - therapeutic use Clinical trials Consumption Dosage Female GABA-B Receptor Agonists - therapeutic use High risk Humans Initiation Male Middle Aged Retrospective Studies Risk Sexual behavior Temperance - statistics & numerical data |
| title | Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers |
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