Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination – Insights from metandienone metabolism

► Investigation of metandienone hydroxylation by cytochrome P450 enzymes. ► CYP21 and CYP3A4 catalyze hydroxylation of normetandienone (NorMD). ► CYP21, CYP3A4, and CYP11B2 take part in generation of 20βOH-NorMD from metandienone. ► Unexpectedly, non-liver CYPs are involved in metandienone long-term...

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Veröffentlicht in:	Toxicology letters 2012-09, Vol.213 (3), p.381-391
Hauptverfasser:	Parr, Maria Kristina, Zöllner, Andy, Fußhöller, Gregor, Opfermann, Georg, Schlörer, Nils, Zorio, Mirela, Bureik, Matthias, Schänzer, Wilhelm
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Anabolic Agents - administration & dosage Anabolic Agents - pharmacokinetics Anabolic Agents - urine Biological and medical sciences Biotransformation Cytochrome P-450 CYP11B2 - metabolism Cytochrome P-450 CYP3A - metabolism Cytochrome P450 Doping control Doping in Sports Gas Chromatography-Mass Spectrometry GC–MS/MS Humans Hydroxylation Male Medical sciences Metabolic pathways Metandienone Methandrostenolone - administration & dosage Methandrostenolone - analogs & derivatives Methandrostenolone - pharmacokinetics Methandrostenolone - urine Middle Aged NMR Performance-Enhancing Substances - administration & dosage Performance-Enhancing Substances - pharmacokinetics Performance-Enhancing Substances - urine Recombinant Proteins - metabolism Steroid 21-Hydroxylase - metabolism Substance Abuse Detection - methods Substrate Specificity Tandem Mass Spectrometry Toxicology
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