A Comprehensive Panel of Turn-On Caspase Biosensors for Investigating Caspase Specificity and Caspase Activation Pathways

Caspases play a central role in apoptosis, differentiation, and proliferation, and represent important therapeutic targets for treating cancer and inflammatory disorders. Toward the goal of developing new tools to probe caspase substrate cleavage specificity as well as to systematically interrogate...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2011-10, Vol.12 (15), p.2353-2364
Hauptverfasser:	Shekhawat, Sujan S., Campbell, Sean T., Ghosh, Indraneel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biosensing Techniques - methods biosensors caspases Caspases - metabolism Cell Line coiled coils Cytosol - enzymology Cytosol - metabolism Enzyme Activation Humans Luminescent Measurements - methods Models, Molecular proteases Rabbits Recombinant Proteins - metabolism Reticulocytes - enzymology Reticulocytes - metabolism Signal Transduction Substrate Specificity Triticum - enzymology
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