Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: An implication for the disrupted barrier mechanism in atopic dermatitis

Abstract Background Although the mechanism(s) involved in the ceramide deficiency in the stratum corneum (SC) of atopic dermatitis (AD) skin is unknown, Th2 type cytokines have been reported to down-regulate ceramide levels in the epidermis. However, almost all research to date has focused on cerami...

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Veröffentlicht in:	Journal of dermatological science 2012-10, Vol.68 (1), p.25-35
Hauptverfasser:	Sawada, Eri, Yoshida, Naoki, Sugiura, Ayumi, Imokawa, Genji
Format:	Artikel
Sprache:	eng
Schlagworte:	Atopic dermatitis Cells, Cultured Ceramide Ceramides - metabolism Cytokines - metabolism Dermatitis, Atopic - genetics Dermatitis, Atopic - immunology Dermatitis, Atopic - metabolism Dermatology Down-Regulation Epidermis - immunology Epidermis - metabolism Gene Expression Regulation, Enzymologic Glucosylceramidase - genetics Glucosylceramidase - metabolism Human epidermal equivalent Humans Keratinocytes - immunology Keratinocytes - metabolism Recombinant Proteins - metabolism Serine C-Palmitoyltransferase - genetics Serine C-Palmitoyltransferase - metabolism Sphingomyelin Phosphodiesterase - genetics Sphingomyelin Phosphodiesterase - metabolism Stratum corneum Th1 Cells - immunology Th1 Cells - metabolism Th1 cytokine Th2 Cells - immunology Th2 Cells - metabolism Th2 cytokine Time Factors
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