Selection of antibodies from synthetic antibody libraries

► We review selection platforms for recombinant antibody repertoires. ► We describe in vitro display systems; phage, ribosome and mRNA display. ► We describe in vivo display systems; bacterial, yeast and mammalian cells display. ► We describe how antibody libraries are constructed. ► We describe the...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2012-10, Vol.526 (2), p.87-98
Hauptverfasser:	Harel Inbar, Noa, Benhar, Itai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibody Affinity Antibody libraries Bacterial surface display engineering Humans Immune repertoires Mammalian cells surface display mammals monoclonal antibodies Naïve repertoires Peptide Library Phage display recombinant antibodies Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - immunology Ribosome display Synthetic repertoires therapeutics Yeast surface display
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