Resveratrol protects neurons from cannulae implantation injury: Implications for deep brain stimulation

Highlights ► Resveratrol protects the brain from mechanical injury. ► Deep brain stimulation surgery can cause astrocytic gliosis and cell dystrophy. ► Resveratrol microinjected into the sub-thalamic nucleus provided protection from deep brain stimulation surgery. ► Resveratrol microinjection induce...

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Veröffentlicht in:	Neuroscience 2012-10, Vol.222, p.333-342
Hauptverfasser:	Constant, J.P, Fraley, G.S, Forbes, E, Hallas, B.H, Leheste, J.R, Torres, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology astrocytic gliosis Behavior, Animal - physiology Biological and medical sciences Catheterization - adverse effects cell division cycle genes Deep Brain Stimulation - adverse effects Deep Brain Stimulation - methods Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dimethyl Sulfoxide - pharmacology Electrodes, Implanted - adverse effects Fluoresceins Fluorescent Dyes Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Glial Fibrillary Acidic Protein - metabolism Immunohistochemistry Male Medical sciences Microinjections motor deficits Neurology Neurons - drug effects Neurons - pathology Neuroprotective Agents Organic Chemicals Parkinson’s disease Polymerase Chain Reaction Postural Balance - drug effects rat Rats Rats, Long-Evans Stilbenes - pharmacology sub-thalamic nucleus Subthalamic Nucleus - pathology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights ► Resveratrol protects the brain from mechanical injury. ► Deep brain stimulation surgery can cause astrocytic gliosis and cell dystrophy. ► Resveratrol microinjected into the sub-thalamic nucleus provided protection from deep brain stimulation surgery. ► Resveratrol microinjection induced the expression of several genes associated with astrocytic gliosis. ► Resveratrol can effectively minimize acute neuronal injury during the course of deep brain stimulation surgery.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.06.067