Reductive alkylation of hyaluronic acid for the synthesis of biocompatible hydrogels by click chemistry

► Oxidation followed by reductive amination of hyaluronic acid. ► Non toxic catalyst 4-Ac-TEMPO and picoline borane used for the reaction. ► Easy scale-up and negligible degradation of the polysaccharide. ► Successful scaffold synthesis from N-alkylated derivates applying click chemistry. Hyaluronan...

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Veröffentlicht in:	Carbohydrate polymers 2012-11, Vol.90 (4), p.1704-1711
Hauptverfasser:	Huerta-Angeles, Gloria, Němcová, Miroslava, Příkopová, Eva, Šmejkalová, Daniela, Pravda, Martin, Kučera, Lukáš, Velebný, Vladimír
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Ac-TEMPO-mediated oxidation Alkylation Applied sciences Biocompatible Materials - chemical synthesis Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured chondrocytes Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Click Chemistry Cross-Linking Reagents - chemistry crosslinking Exact sciences and technology Fourier transform infrared spectroscopy Humans Hyaluronic acid Hyaluronic Acid - chemistry hydrocolloids Hydrogels - chemical synthesis mechanical properties Natural polymers nuclear magnetic resonance spectroscopy oxidants oxidation Physicochemistry of polymers primary amines Reductive alkylation Rheology sodium hypochlorite sowing Starch and polysaccharides Tissue Engineering
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