Specific decidual CD14+ cells hamper cognate NK cell proliferation and cytolytic mediator expression after mucin 1 treatment in vitro

Abstract Mucin 1 (MUC1) forms a glycocalyx on the surface of decidual epithelial cells that needs to be removed for successful embryo attachment. We investigated whether MUC1 affects human early pregnancy decidual CD14+ cells and their interactions with cognate decidual natural killer (NK) cells. FI...

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Veröffentlicht in:	Journal of reproductive immunology 2012-09, Vol.95 (1), p.36-45
Hauptverfasser:	Laskarin, Gordana, Medancic, Suzana Srsen, Redzovic, Arnela, Duric, Danijel, Rukavina, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, CD - immunology Antigens, CD - metabolism Cell Proliferation - drug effects Decidua Decidua - cytology Decidua - immunology Decidua - metabolism Epithelial Cells - cytology Epithelial Cells - immunology Female Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Humans Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lipopolysaccharide Receptors - biosynthesis Lipopolysaccharide Receptors - immunology Lipopolysaccharides - pharmacology Macrophages Macrophages - cytology Macrophages - immunology Macrophages - metabolism Mucin 1 Mucin-1 - immunology Mucin-1 - metabolism Mucin-1 - pharmacology NK cells Obstetrics and Gynecology Pregnancy Pregnancy - immunology Pregnancy - metabolism Pregnancy Trimester, First - immunology Pregnancy Trimester, First - metabolism Receptors, CCR5 - immunology Receptors, CCR5 - metabolism TNF-Related Apoptosis-Inducing Ligand - immunology TNF-Related Apoptosis-Inducing Ligand - metabolism Trophoblasts - cytology Trophoblasts - immunology Trophoblasts - metabolism
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