Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants

ALK rearrangement-positive lung cancers can be effectively treated with ALK inhibitors. However, the magnitude and duration of response is heterogeneous. In addition, acquired resistance limits the efficacy of ALK inhibitors, with most upfront resistance mechanisms being unknown. By making use of th...

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Veröffentlicht in:	Clinical cancer research 2012-09, Vol.18 (17), p.4682-4690
Hauptverfasser:	HEUCKMANN, Johannes M, BALKE-WANT, Hyatt, KÜPPERS, Ralf, THOMAS, Roman K, MALCHERS, Florian, PEIFER, Martin, SOS, Martin L, KOKER, Mirjam, MEDER, Lydia, LOVLY, Christine M, HEUKAMP, Lukas C, PAO, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma of Lung Anaplastic Lymphoma Kinase Animals Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Carcinoma, Non-Small-Cell Lung - genetics Cell Line, Tumor Cell Proliferation - drug effects Crizotinib HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Humans Kinesin - genetics Kinesin - metabolism Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical sciences Mice NIH 3T3 Cells Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Pharmacology. Drug treatments Protein Kinase Inhibitors - administration & dosage Protein Stability - drug effects Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Pyrazoles - administration & dosage Pyridines - administration & dosage Pyrimidines - administration & dosage Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Signal Transduction - drug effects
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