Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-α-induced neutrophil apoptosis

Autophagy and apoptosis cooperate to modulate cell survival. Neutrophils are short-lived cells and apoptosis is considered to be the major mechanism of their death. In the present study, we addressed whether autophagy regulates neutrophil apoptosis and investigated the effects of autophagy inhibitio...

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Veröffentlicht in:	Apoptosis (London) 2012-10, Vol.17 (10), p.1050-1065
Hauptverfasser:	Pliyev, Boris K., Menshikov, Mikhail
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Amino Acid Chloromethyl Ketones - pharmacology Apoptosis - drug effects Autophagy - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Chloroquine - pharmacology Down-Regulation Humans Myeloid Cell Leukemia Sequence 1 Protein Neutrophils - cytology Neutrophils - drug effects Oncology Original Paper Proto-Oncogene Proteins c-bcl-2 - genetics Quinolines - pharmacology Tumor Necrosis Factor-alpha - pharmacology Virology
Online-Zugang:	Volltext
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