Placental pathology, birthweight discordance, and growth restriction in twin pregnancy: results of the ESPRiT Study
Objective We sought to evaluate the association between placental histological abnormalities and birthweight discordance and growth restriction in twin pregnancies. Study design We performed a multicenter, prospective study of twin pregnancies. Placentas were examined for evidence of infarction, ret...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2012-09, Vol.207 (3), p.220.e1-220.e5 |
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| creator | Kent, Etaoin M., MRCOG Breathnach, Fionnuala M., MD Gillan, John E., MD McAuliffe, Fionnuala M., MD Geary, Michael P., MD Daly, Sean, MD Higgins, John R., MD Hunter, Alyson, MD Morrison, John J., MD Burke, Gerard, FRCOG Higgins, Shane, FRCOG Carroll, Stephen, MD Dicker, Patrick, PhD Manning, Fiona, PhD Tully, Elizabeth, PhD Malone, Fergal D., MD |
| description | Objective We sought to evaluate the association between placental histological abnormalities and birthweight discordance and growth restriction in twin pregnancies. Study design We performed a multicenter, prospective study of twin pregnancies. Placentas were examined for evidence of infarction, retroplacental hemorrhage, chorangioma, subchorial fibrin, or abnormal villus maturation. Association of placental lesions with chorionicity, birthweight discordance, and growth restriction were assessed. Results In all, 668 twin pairs were studied, 21.1% monochorionic and 78.9% dichorionic. Histological abnormalities were more frequent in placentas of smaller twins of birthweight discordant pairs ( P = .02) and in placentas of small for gestational age infants ( P = .0001) when compared to controls. The association of placental abnormalities with both birthweight discordance and small for gestational age was significant for dichorionic twins ( P = .01 and .0001, respectively). No such association was seen in monochorionic twins. Conclusion In a large, prospective, multicenter study, we observed a strong relationship between abnormalities of placental histology and birthweight discordance and growth restriction in dichorionic, but not monochorionic, twin pregnancies. |
| doi_str_mv | 10.1016/j.ajog.2012.06.022 |
| format | Article |
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Study design We performed a multicenter, prospective study of twin pregnancies. Placentas were examined for evidence of infarction, retroplacental hemorrhage, chorangioma, subchorial fibrin, or abnormal villus maturation. Association of placental lesions with chorionicity, birthweight discordance, and growth restriction were assessed. Results In all, 668 twin pairs were studied, 21.1% monochorionic and 78.9% dichorionic. Histological abnormalities were more frequent in placentas of smaller twins of birthweight discordant pairs ( P = .02) and in placentas of small for gestational age infants ( P = .0001) when compared to controls. The association of placental abnormalities with both birthweight discordance and small for gestational age was significant for dichorionic twins ( P = .01 and .0001, respectively). No such association was seen in monochorionic twins. Conclusion In a large, prospective, multicenter study, we observed a strong relationship between abnormalities of placental histology and birthweight discordance and growth restriction in dichorionic, but not monochorionic, twin pregnancies.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2012.06.022</identifier><identifier>PMID: 22835491</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Birth Weight ; birthweight discordance ; Diseases of mother, fetus and pregnancy ; Female ; Fetal Growth Retardation - diagnostic imaging ; Fetal Growth Retardation - etiology ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Obstetrics and Gynecology ; Placenta Diseases - pathology ; placental infarcts ; placental pathology ; Pregnancy ; Pregnancy. Fetus. Placenta ; Prospective Studies ; retroplacental hematoma ; subchorial fibrin ; twin pregnancy ; Twins, Dizygotic ; Twins, Monozygotic ; Ultrasonography, Prenatal</subject><ispartof>American journal of obstetrics and gynecology, 2012-09, Vol.207 (3), p.220.e1-220.e5</ispartof><rights>Mosby, Inc.</rights><rights>2012 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-60e2101fcd9afdd5332266b3555867a68c7728b6de6daaf3b1cfbe1929c2270d3</citedby><cites>FETCH-LOGICAL-c441t-60e2101fcd9afdd5332266b3555867a68c7728b6de6daaf3b1cfbe1929c2270d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937812006230$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26351683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22835491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kent, Etaoin M., MRCOG</creatorcontrib><creatorcontrib>Breathnach, Fionnuala M., MD</creatorcontrib><creatorcontrib>Gillan, John E., MD</creatorcontrib><creatorcontrib>McAuliffe, Fionnuala M., MD</creatorcontrib><creatorcontrib>Geary, Michael P., MD</creatorcontrib><creatorcontrib>Daly, Sean, MD</creatorcontrib><creatorcontrib>Higgins, John R., MD</creatorcontrib><creatorcontrib>Hunter, Alyson, MD</creatorcontrib><creatorcontrib>Morrison, John J., MD</creatorcontrib><creatorcontrib>Burke, Gerard, FRCOG</creatorcontrib><creatorcontrib>Higgins, Shane, FRCOG</creatorcontrib><creatorcontrib>Carroll, Stephen, MD</creatorcontrib><creatorcontrib>Dicker, Patrick, PhD</creatorcontrib><creatorcontrib>Manning, Fiona, PhD</creatorcontrib><creatorcontrib>Tully, Elizabeth, PhD</creatorcontrib><creatorcontrib>Malone, Fergal D., MD</creatorcontrib><title>Placental pathology, birthweight discordance, and growth restriction in twin pregnancy: results of the ESPRiT Study</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective We sought to evaluate the association between placental histological abnormalities and birthweight discordance and growth restriction in twin pregnancies. Study design We performed a multicenter, prospective study of twin pregnancies. Placentas were examined for evidence of infarction, retroplacental hemorrhage, chorangioma, subchorial fibrin, or abnormal villus maturation. Association of placental lesions with chorionicity, birthweight discordance, and growth restriction were assessed. Results In all, 668 twin pairs were studied, 21.1% monochorionic and 78.9% dichorionic. Histological abnormalities were more frequent in placentas of smaller twins of birthweight discordant pairs ( P = .02) and in placentas of small for gestational age infants ( P = .0001) when compared to controls. The association of placental abnormalities with both birthweight discordance and small for gestational age was significant for dichorionic twins ( P = .01 and .0001, respectively). No such association was seen in monochorionic twins. Conclusion In a large, prospective, multicenter study, we observed a strong relationship between abnormalities of placental histology and birthweight discordance and growth restriction in dichorionic, but not monochorionic, twin pregnancies.</description><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>birthweight discordance</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Fetal Growth Retardation - diagnostic imaging</subject><subject>Fetal Growth Retardation - etiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta Diseases - pathology</subject><subject>placental infarcts</subject><subject>placental pathology</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prospective Studies</subject><subject>retroplacental hematoma</subject><subject>subchorial fibrin</subject><subject>twin pregnancy</subject><subject>Twins, Dizygotic</subject><subject>Twins, Monozygotic</subject><subject>Ultrasonography, Prenatal</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kluL1DAUgIMo7rj6B3yQvAg-bGsu07QVEWRZL7Dg4qzPIU1O29ROMyapQ_-9KTMq-OBLQsh3bh8HoeeU5JRQ8XrI1eC6nBHKciJywtgDtKGkLjNRieoh2hBCWFbzsrpAT0IY1ier2WN0wVjFi21NNyjcjUrDFNWIDyr2bnTdcoUb62N_BNv1ERsbtPNGTRqusJoM7rw7xh57CNFbHa2bsJ1wPKbj4KGbErm8Wb_nMQbsWhx7wDe7u6_2Hu_ibJan6FGrxgDPzvcl-vbh5v76U3b75ePn6_e3md5uacwEAZbmbLWpVWtMwTljQjS8KIpKlEpUuixZ1QgDwijV8obqtgFas1ozVhLDL9GrU96Ddz_m1K7cp1lgHNUEbg6SkqSm2gpRJZSdUO1dCB5aefB2r_ySILnKloNcZctVtiRCJpMp6MU5_9zswfwJ-W03AS_PgApaja1Pamz4ywle0FQ8cW9PHCQbPy14GbSFJNxYDzpK4-z_-3j3T7ge7WRTxe-wQBjc7KfkWVIZUozcrXuwbgVlhAjGCf8F3XizOA</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Kent, Etaoin M., MRCOG</creator><creator>Breathnach, Fionnuala M., MD</creator><creator>Gillan, John E., MD</creator><creator>McAuliffe, Fionnuala M., MD</creator><creator>Geary, Michael P., MD</creator><creator>Daly, Sean, MD</creator><creator>Higgins, John R., MD</creator><creator>Hunter, Alyson, MD</creator><creator>Morrison, John J., MD</creator><creator>Burke, Gerard, FRCOG</creator><creator>Higgins, Shane, FRCOG</creator><creator>Carroll, Stephen, MD</creator><creator>Dicker, Patrick, PhD</creator><creator>Manning, Fiona, PhD</creator><creator>Tully, Elizabeth, PhD</creator><creator>Malone, Fergal D., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Placental pathology, birthweight discordance, and growth restriction in twin pregnancy: results of the ESPRiT Study</title><author>Kent, Etaoin M., MRCOG ; Breathnach, Fionnuala M., MD ; Gillan, John E., MD ; McAuliffe, Fionnuala M., MD ; Geary, Michael P., MD ; Daly, Sean, MD ; Higgins, John R., MD ; Hunter, Alyson, MD ; Morrison, John J., MD ; Burke, Gerard, FRCOG ; Higgins, Shane, FRCOG ; Carroll, Stephen, MD ; Dicker, Patrick, PhD ; Manning, Fiona, PhD ; Tully, Elizabeth, PhD ; Malone, Fergal D., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-60e2101fcd9afdd5332266b3555867a68c7728b6de6daaf3b1cfbe1929c2270d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>birthweight discordance</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Fetal Growth Retardation - diagnostic imaging</topic><topic>Fetal Growth Retardation - etiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta Diseases - pathology</topic><topic>placental infarcts</topic><topic>placental pathology</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prospective Studies</topic><topic>retroplacental hematoma</topic><topic>subchorial fibrin</topic><topic>twin pregnancy</topic><topic>Twins, Dizygotic</topic><topic>Twins, Monozygotic</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kent, Etaoin M., MRCOG</creatorcontrib><creatorcontrib>Breathnach, Fionnuala M., MD</creatorcontrib><creatorcontrib>Gillan, John E., MD</creatorcontrib><creatorcontrib>McAuliffe, Fionnuala M., MD</creatorcontrib><creatorcontrib>Geary, Michael P., MD</creatorcontrib><creatorcontrib>Daly, Sean, MD</creatorcontrib><creatorcontrib>Higgins, John R., MD</creatorcontrib><creatorcontrib>Hunter, Alyson, MD</creatorcontrib><creatorcontrib>Morrison, John J., MD</creatorcontrib><creatorcontrib>Burke, Gerard, FRCOG</creatorcontrib><creatorcontrib>Higgins, Shane, FRCOG</creatorcontrib><creatorcontrib>Carroll, Stephen, MD</creatorcontrib><creatorcontrib>Dicker, Patrick, PhD</creatorcontrib><creatorcontrib>Manning, Fiona, PhD</creatorcontrib><creatorcontrib>Tully, Elizabeth, PhD</creatorcontrib><creatorcontrib>Malone, Fergal D., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kent, Etaoin M., MRCOG</au><au>Breathnach, Fionnuala M., MD</au><au>Gillan, John E., MD</au><au>McAuliffe, Fionnuala M., MD</au><au>Geary, Michael P., MD</au><au>Daly, Sean, MD</au><au>Higgins, John R., MD</au><au>Hunter, Alyson, MD</au><au>Morrison, John J., MD</au><au>Burke, Gerard, FRCOG</au><au>Higgins, Shane, FRCOG</au><au>Carroll, Stephen, MD</au><au>Dicker, Patrick, PhD</au><au>Manning, Fiona, PhD</au><au>Tully, Elizabeth, PhD</au><au>Malone, Fergal D., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Placental pathology, birthweight discordance, and growth restriction in twin pregnancy: results of the ESPRiT Study</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>207</volume><issue>3</issue><spage>220.e1</spage><epage>220.e5</epage><pages>220.e1-220.e5</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective We sought to evaluate the association between placental histological abnormalities and birthweight discordance and growth restriction in twin pregnancies. Study design We performed a multicenter, prospective study of twin pregnancies. Placentas were examined for evidence of infarction, retroplacental hemorrhage, chorangioma, subchorial fibrin, or abnormal villus maturation. Association of placental lesions with chorionicity, birthweight discordance, and growth restriction were assessed. Results In all, 668 twin pairs were studied, 21.1% monochorionic and 78.9% dichorionic. Histological abnormalities were more frequent in placentas of smaller twins of birthweight discordant pairs ( P = .02) and in placentas of small for gestational age infants ( P = .0001) when compared to controls. The association of placental abnormalities with both birthweight discordance and small for gestational age was significant for dichorionic twins ( P = .01 and .0001, respectively). No such association was seen in monochorionic twins. Conclusion In a large, prospective, multicenter study, we observed a strong relationship between abnormalities of placental histology and birthweight discordance and growth restriction in dichorionic, but not monochorionic, twin pregnancies.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>22835491</pmid><doi>10.1016/j.ajog.2012.06.022</doi><tpages>3</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 2012-09, Vol.207 (3), p.220.e1-220.e5 |
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| subjects | Biological and medical sciences Birth Weight birthweight discordance Diseases of mother, fetus and pregnancy Female Fetal Growth Retardation - diagnostic imaging Fetal Growth Retardation - etiology Gynecology. Andrology. Obstetrics Humans Medical sciences Obstetrics and Gynecology Placenta Diseases - pathology placental infarcts placental pathology Pregnancy Pregnancy. Fetus. Placenta Prospective Studies retroplacental hematoma subchorial fibrin twin pregnancy Twins, Dizygotic Twins, Monozygotic Ultrasonography, Prenatal |
| title | Placental pathology, birthweight discordance, and growth restriction in twin pregnancy: results of the ESPRiT Study |
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