Antipsychotic drugs cause bradycardia in GD 13 rat embryos in vitro

► Effects of antipsychotic drugs on heart function were examined on gestational day 13 rat embryos in vitro. ► All tested antipsychotic drugs caused bradycardia. ► Safety margins were much lower for haloperidol and quentiapine than for the other 6 drugs tested. This study investigated the effects of...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2012-11, Vol.34 (3), p.443-450
Hauptverfasser:	Gunnström, M., Ababneh, D., Webster, W.S., Oakes, D., Ritchie, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - adverse effects Antipsychotics Biological and medical sciences Bradycardia - chemically induced Bradycardia - physiopathology Cardiac dysrhythmias Cardiology. Vascular system Embryo, Mammalian - drug effects Embryo, Mammalian - physiology Embryo, Mammalian - physiopathology Embryo/fetal physiology Embryology: invertebrates and vertebrates. Teratology ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels - antagonists & inhibitors Ether-A-Go-Go Potassium Channels - physiology Female Fundamental and applied biological sciences. Psychology Heart Heart function Heart Rate - drug effects hERG In vitro screens Mechanisms of teratogenesis Medical sciences NAV1.5 Voltage-Gated Sodium Channel - physiology Pharmaceuticals Potassium Channel Blockers - adverse effects Pregnancy Rats Rats, Sprague-Dawley Sodium Channel Blockers - adverse effects Teratology. Teratogens Toxicology
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