Secondary Causes of Dyslipidemia
The causes of the lipid disorders in patients referred to specialty clinics for difficult-to-treat dyslipidemias are likely multifactorial. However, the importance of evaluating for secondary causes is unclear. The investigators performed a chart review of new patients referred to the University of...
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| Veröffentlicht in: | The American journal of cardiology 2012-09, Vol.110 (6), p.823-825 |
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| creator | Vodnala, Deepthi, MD Rubenfire, Melvyn, MD Brook, Robert D., MD |
| description | The causes of the lipid disorders in patients referred to specialty clinics for difficult-to-treat dyslipidemias are likely multifactorial. However, the importance of evaluating for secondary causes is unclear. The investigators performed a chart review of new patients referred to the University of Michigan Lipid Clinic from January 2004 to June 2011 (n = 824) to evaluate for the prevalence of several secondary causes of dyslipidemia. In addition to lipoproteins, new patients were assessed for secondary dyslipidemias by a standardized protocol consisting of laboratory testing, a nutritional evaluation, and medical history. These data were evaluated to determine the prevalence of several secondary causes of dyslipidemia. A total of 363 separate factors were identified in the 824 patients that were thought to be potential secondary causes of dyslipidemia. Because some patients (n = 83 [10%]) had multiple conditions, there were 230 (28% of the cohort) with ≥1 potential secondary dyslipidemias. The most common conditions were excessive alcohol intake (n = 82 [10%]), uncontrolled diabetes mellitus (n = 68 [8%]), and overt albuminuria. Although other causes occurred less frequently (each individually found in |
| doi_str_mv | 10.1016/j.amjcard.2012.04.062 |
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However, the importance of evaluating for secondary causes is unclear. The investigators performed a chart review of new patients referred to the University of Michigan Lipid Clinic from January 2004 to June 2011 (n = 824) to evaluate for the prevalence of several secondary causes of dyslipidemia. In addition to lipoproteins, new patients were assessed for secondary dyslipidemias by a standardized protocol consisting of laboratory testing, a nutritional evaluation, and medical history. These data were evaluated to determine the prevalence of several secondary causes of dyslipidemia. A total of 363 separate factors were identified in the 824 patients that were thought to be potential secondary causes of dyslipidemia. Because some patients (n = 83 [10%]) had multiple conditions, there were 230 (28% of the cohort) with ≥1 potential secondary dyslipidemias. The most common conditions were excessive alcohol intake (n = 82 [10%]), uncontrolled diabetes mellitus (n = 68 [8%]), and overt albuminuria. Although other causes occurred less frequently (each individually found in <5% of patients), altogether they were present in a substantial portion of patients (n = 102 [12%]). In conclusion, nearly 1/3 of patients referred to a specialty clinic had identifiable secondary conditions plausibly contributing to their dyslipidemia. Numerous disorders were identified, with diabetes mellitus and excessive alcohol being the most common.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2012.04.062</identifier><identifier>PMID: 22658245</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Alcohol use ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular ; Cholesterol ; Colleges & universities ; Diet ; Dyslipidemias - epidemiology ; Dyslipidemias - etiology ; Female ; Humans ; Hypothyroidism ; Lipids ; Lipoproteins ; Male ; Medical sciences ; Middle Aged ; Physicians ; Prevalence ; Retrospective Studies ; Risk Factors ; Triglycerides</subject><ispartof>The American journal of cardiology, 2012-09, Vol.110 (6), p.823-825</ispartof><rights>2012</rights><rights>2015 INIST-CNRS</rights><rights>Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Sep 15, 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-bab79ea044f4d775a31f5c811486bc74747b59dd21869bfb2ca24a4902e6872d3</citedby><cites>FETCH-LOGICAL-c525t-bab79ea044f4d775a31f5c811486bc74747b59dd21869bfb2ca24a4902e6872d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1081453117?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26380819$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22658245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vodnala, Deepthi, MD</creatorcontrib><creatorcontrib>Rubenfire, Melvyn, MD</creatorcontrib><creatorcontrib>Brook, Robert D., MD</creatorcontrib><title>Secondary Causes of Dyslipidemia</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The causes of the lipid disorders in patients referred to specialty clinics for difficult-to-treat dyslipidemias are likely multifactorial. However, the importance of evaluating for secondary causes is unclear. The investigators performed a chart review of new patients referred to the University of Michigan Lipid Clinic from January 2004 to June 2011 (n = 824) to evaluate for the prevalence of several secondary causes of dyslipidemia. In addition to lipoproteins, new patients were assessed for secondary dyslipidemias by a standardized protocol consisting of laboratory testing, a nutritional evaluation, and medical history. These data were evaluated to determine the prevalence of several secondary causes of dyslipidemia. A total of 363 separate factors were identified in the 824 patients that were thought to be potential secondary causes of dyslipidemia. Because some patients (n = 83 [10%]) had multiple conditions, there were 230 (28% of the cohort) with ≥1 potential secondary dyslipidemias. The most common conditions were excessive alcohol intake (n = 82 [10%]), uncontrolled diabetes mellitus (n = 68 [8%]), and overt albuminuria. Although other causes occurred less frequently (each individually found in <5% of patients), altogether they were present in a substantial portion of patients (n = 102 [12%]). In conclusion, nearly 1/3 of patients referred to a specialty clinic had identifiable secondary conditions plausibly contributing to their dyslipidemia. Numerous disorders were identified, with diabetes mellitus and excessive alcohol being the most common.</description><subject>Alcohol use</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cholesterol</subject><subject>Colleges & universities</subject><subject>Diet</subject><subject>Dyslipidemias - epidemiology</subject><subject>Dyslipidemias - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Lipids</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Physicians</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Triglycerides</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkUtr3DAUhUVpaKZpf0LLQCl0Y1dXlmRpkxCmzQMCXaRdC1m6Brl-TKRxYP59ZWaaQDZBCyH4ztG55xLyCWgJFOT3rrRD52z0JaPASspLKtkbsgJV6wI0VG_JilLKCg1cn5L3KXX5CSDkO3LKmBSKcbEi63t00-ht3K83dk6Y1lO7_rFPfdgGj0OwH8hJa_uEH4_3Gflz9fP35qa4-3V9u7m8K5xgYlc0tqk1Wsp5y31dC1tBK5wC4Eo2rub5NEJ7z0BJ3bQNc5ZxyzVlKFXNfHVGvh18t3F6mDHtzBCSw763I05zMkCrWkrGaJ3RLy_QbprjmNNlSgEXFcBCiQPl4pRSxNZsYxjyoBkyS4WmM8cKzVKhodzkCrPu89F9bgb0T6r_nWXg6xGwydm-jXZ0IT1zslI5hc7cxYHDXNtjwGiSCzg69CGi2xk_hVejnL9wcH0YQ_70L-4xPU9tUtaY-2Xfy7ohm1RcqOofzeii7Q</recordid><startdate>20120915</startdate><enddate>20120915</enddate><creator>Vodnala, Deepthi, MD</creator><creator>Rubenfire, Melvyn, MD</creator><creator>Brook, Robert D., MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20120915</creationdate><title>Secondary Causes of Dyslipidemia</title><author>Vodnala, Deepthi, MD ; Rubenfire, Melvyn, MD ; Brook, Robert D., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-bab79ea044f4d775a31f5c811486bc74747b59dd21869bfb2ca24a4902e6872d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alcohol use</topic><topic>Biological and medical sciences</topic><topic>Cardiology. 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The most common conditions were excessive alcohol intake (n = 82 [10%]), uncontrolled diabetes mellitus (n = 68 [8%]), and overt albuminuria. Although other causes occurred less frequently (each individually found in <5% of patients), altogether they were present in a substantial portion of patients (n = 102 [12%]). In conclusion, nearly 1/3 of patients referred to a specialty clinic had identifiable secondary conditions plausibly contributing to their dyslipidemia. Numerous disorders were identified, with diabetes mellitus and excessive alcohol being the most common.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22658245</pmid><doi>10.1016/j.amjcard.2012.04.062</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alcohol use Biological and medical sciences Cardiology. Vascular system Cardiovascular Cholesterol Colleges & universities Diet Dyslipidemias - epidemiology Dyslipidemias - etiology Female Humans Hypothyroidism Lipids Lipoproteins Male Medical sciences Middle Aged Physicians Prevalence Retrospective Studies Risk Factors Triglycerides |
| title | Secondary Causes of Dyslipidemia |
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