Polymorphisms of the drug transporter gene ABCB1 predict side effects of treatment with cabergoline in patients with PRL adenomas

IntroductionTreatment with dopamine agonists in patients with prolactin (PRL) adenomas and Parkinson's disease is associated with central side effects. Central side effects may depend on a substance's ability to pass the blood–brain barrier, which can be actively controlled by transporter...

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Veröffentlicht in:	European journal of endocrinology 2012-09, Vol.167 (3), p.327-335
Hauptverfasser:	Athanasoulia, A P, Sievers, C, Ising, M, Brockhaus, A C, Yassouridis, A, Stalla, G K, Uhr, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antineoplastic Agents - adverse effects ATP Binding Cassette Transporter, Sub-Family D, Member 1 ATP-Binding Cassette Transporters - genetics Biological and medical sciences Case-Control Studies Clinical Study Endocrinopathies Ergolines - adverse effects Fatigue - chemically induced Fatigue - genetics Female Fundamental and applied biological sciences. Psychology Headache - chemically induced Headache - genetics Humans Male Medical sciences Mice Mice, Knockout Middle Aged Pituitary Neoplasms - drug therapy Pituitary Neoplasms - genetics Polymorphism, Single Nucleotide - genetics Predictive Value of Tests Prolactinoma - drug therapy Prolactinoma - genetics Treatment Outcome Vertebrates: endocrinology
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