Epidemiology of small intestinal atresia in Europe: a register-based study
Background The epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe. Methods Cases of SIA delivered during January...
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| Veröffentlicht in: | Archives of disease in childhood. Fetal and neonatal edition 2012-09, Vol.97 (5), p.F353-F358 |
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| creator | Best, Kate E Tennant, Peter W G Addor, Marie-Claude Bianchi, Fabrizio Boyd, Patricia Calzolari, Elisa Dias, Carlos Matias Doray, Berenice Draper, Elizabeth Garne, Ester Gatt, Miriam Greenlees, Ruth Haeusler, Martin Khoshnood, Babak McDonnell, Bob Mullaney, Carmel Nelen, Vera Randrianaivo, Hanitra Rissmann, Anke Salvador, Joaquin Tucker, David Wellesly, Diana Rankin, Judith |
| description | Background The epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe. Methods Cases of SIA delivered during January 1990 to December 2006 notified to 20 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept. Results In total 1133 SIA cases were reported among 5126, 164 registered births. Of 1044 singleton cases, 215 (20.6%) cases were associated with a chromosomal anomaly. Of 829 singleton SIA cases with normal karyotype, 221 (26.7%) were associated with other structural anomalies. Considering cases with normal karyotype, the total prevalence per 10 000 births was 1.6 (95% CI 1.5 to 1.7) for SIA, 0.9 (95% CI 0.8 to 1.0) for duodenal atresia and 0.7 (95% CI 0.7 to 0.8) for jejunoileal atresia (JIA). There was no significant trend in SIA, duodenal atresia or JIA prevalence over time (RR=1.0, 95% credible interval (CrI): 1.0 to 1.0 for each), but SIA and duodenal atresia prevalence varied by geographical location (p=0.03 and p=0.04, respectively). There was weak evidence of an increased risk of SIA in mothers aged less than 20 years compared with mothers aged 20 to 29 years (RR=1.3, 95% CrI: 1.0 to 1.8). Conclusion This study found no evidence of a temporal trend in the prevalence of SIA, duodenal atresia or JIA, although SIA and duodenal atresia prevalence varied significantly between registers. |
| doi_str_mv | 10.1136/fetalneonatal-2011-300631 |
| format | Article |
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This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe. Methods Cases of SIA delivered during January 1990 to December 2006 notified to 20 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept. Results In total 1133 SIA cases were reported among 5126, 164 registered births. Of 1044 singleton cases, 215 (20.6%) cases were associated with a chromosomal anomaly. Of 829 singleton SIA cases with normal karyotype, 221 (26.7%) were associated with other structural anomalies. Considering cases with normal karyotype, the total prevalence per 10 000 births was 1.6 (95% CI 1.5 to 1.7) for SIA, 0.9 (95% CI 0.8 to 1.0) for duodenal atresia and 0.7 (95% CI 0.7 to 0.8) for jejunoileal atresia (JIA). There was no significant trend in SIA, duodenal atresia or JIA prevalence over time (RR=1.0, 95% credible interval (CrI): 1.0 to 1.0 for each), but SIA and duodenal atresia prevalence varied by geographical location (p=0.03 and p=0.04, respectively). There was weak evidence of an increased risk of SIA in mothers aged less than 20 years compared with mothers aged 20 to 29 years (RR=1.3, 95% CrI: 1.0 to 1.8). Conclusion This study found no evidence of a temporal trend in the prevalence of SIA, duodenal atresia or JIA, although SIA and duodenal atresia prevalence varied significantly between registers.</description><identifier>ISSN: 1359-2998</identifier><identifier>EISSN: 1468-2052</identifier><identifier>DOI: 10.1136/fetalneonatal-2011-300631</identifier><identifier>PMID: 22933095</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</publisher><subject>Age ; Binomial distribution ; Births ; Duodenal Obstruction - congenital ; Epidemiology ; Europe - epidemiology ; Female ; Heterogeneity ; Humans ; Intestinal Atresia - epidemiology ; Intestine, Small - abnormalities ; Karyotypes ; Maternal Age ; Population ; Pregnancy ; Pregnancy Outcome ; Prevalence ; Proportional Hazards Models ; Registries ; Studies ; Survival analysis ; Trends</subject><ispartof>Archives of disease in childhood. Fetal and neonatal edition, 2012-09, Vol.97 (5), p.F353-F358</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2012 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b498t-9b4a168605e8e992784bccd3c778302d41ffa198f98d111cf7671cba20e84a803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://fn.bmj.com/content/97/5/F353.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://fn.bmj.com/content/97/5/F353.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22933095$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Best, Kate E</creatorcontrib><creatorcontrib>Tennant, Peter W G</creatorcontrib><creatorcontrib>Addor, Marie-Claude</creatorcontrib><creatorcontrib>Bianchi, Fabrizio</creatorcontrib><creatorcontrib>Boyd, Patricia</creatorcontrib><creatorcontrib>Calzolari, Elisa</creatorcontrib><creatorcontrib>Dias, Carlos Matias</creatorcontrib><creatorcontrib>Doray, Berenice</creatorcontrib><creatorcontrib>Draper, Elizabeth</creatorcontrib><creatorcontrib>Garne, Ester</creatorcontrib><creatorcontrib>Gatt, Miriam</creatorcontrib><creatorcontrib>Greenlees, Ruth</creatorcontrib><creatorcontrib>Haeusler, Martin</creatorcontrib><creatorcontrib>Khoshnood, Babak</creatorcontrib><creatorcontrib>McDonnell, Bob</creatorcontrib><creatorcontrib>Mullaney, Carmel</creatorcontrib><creatorcontrib>Nelen, Vera</creatorcontrib><creatorcontrib>Randrianaivo, Hanitra</creatorcontrib><creatorcontrib>Rissmann, Anke</creatorcontrib><creatorcontrib>Salvador, Joaquin</creatorcontrib><creatorcontrib>Tucker, David</creatorcontrib><creatorcontrib>Wellesly, Diana</creatorcontrib><creatorcontrib>Rankin, Judith</creatorcontrib><title>Epidemiology of small intestinal atresia in Europe: a register-based study</title><title>Archives of disease in childhood. Fetal and neonatal edition</title><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><description>Background The epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe. Methods Cases of SIA delivered during January 1990 to December 2006 notified to 20 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept. Results In total 1133 SIA cases were reported among 5126, 164 registered births. Of 1044 singleton cases, 215 (20.6%) cases were associated with a chromosomal anomaly. Of 829 singleton SIA cases with normal karyotype, 221 (26.7%) were associated with other structural anomalies. Considering cases with normal karyotype, the total prevalence per 10 000 births was 1.6 (95% CI 1.5 to 1.7) for SIA, 0.9 (95% CI 0.8 to 1.0) for duodenal atresia and 0.7 (95% CI 0.7 to 0.8) for jejunoileal atresia (JIA). There was no significant trend in SIA, duodenal atresia or JIA prevalence over time (RR=1.0, 95% credible interval (CrI): 1.0 to 1.0 for each), but SIA and duodenal atresia prevalence varied by geographical location (p=0.03 and p=0.04, respectively). There was weak evidence of an increased risk of SIA in mothers aged less than 20 years compared with mothers aged 20 to 29 years (RR=1.3, 95% CrI: 1.0 to 1.8). Conclusion This study found no evidence of a temporal trend in the prevalence of SIA, duodenal atresia or JIA, although SIA and duodenal atresia prevalence varied significantly between registers.</description><subject>Age</subject><subject>Binomial distribution</subject><subject>Births</subject><subject>Duodenal Obstruction - congenital</subject><subject>Epidemiology</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Intestinal Atresia - epidemiology</subject><subject>Intestine, Small - abnormalities</subject><subject>Karyotypes</subject><subject>Maternal Age</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Prevalence</subject><subject>Proportional Hazards Models</subject><subject>Registries</subject><subject>Studies</subject><subject>Survival analysis</subject><subject>Trends</subject><issn>1359-2998</issn><issn>1468-2052</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqVkD1PwzAQhi0EoqXwF1AQC0vAFzv-YEOlUKoKloLYLCdxqpSkKXYi0X-Po5RKsDGddX7u_PpB6ALwNQBhN7lpdLk29Vr7GkYYICQYMwIHaAiUCd-Ko0N_JrEMIynFAJ04t8IYA-f8GA2iSBKCZTxEs8mmyExV1GW93AZ1HrhKl2VQrBvjmmKty0A31rhC-1YwaW29MbeBDqxZFq4xNky0M1ngmjbbnqKjXJfOnO3qCL0-TBbjaTh_eXwa383DhErRhDKhGphgODbCSBlxQZM0zUjKuSA4yijkuQYpcikyAEhzzjikiY6wEVQLTEboqt-7sfVn62OqqnCpKUvtlbROASacMSyE9OjlH3RVt9b_ylNcYEolMOIp2VOprZ2zJlcbW1Tabv0q1QlXv4SrTrjqhfvZ890LbVKZbD_5Y9gDYQ90vr7299p-KMYJj9Xz21i9zzCn94up6sLQnk-q1T9yfAP6FJ9n</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Best, Kate E</creator><creator>Tennant, Peter W G</creator><creator>Addor, Marie-Claude</creator><creator>Bianchi, Fabrizio</creator><creator>Boyd, Patricia</creator><creator>Calzolari, Elisa</creator><creator>Dias, Carlos Matias</creator><creator>Doray, Berenice</creator><creator>Draper, Elizabeth</creator><creator>Garne, Ester</creator><creator>Gatt, Miriam</creator><creator>Greenlees, Ruth</creator><creator>Haeusler, Martin</creator><creator>Khoshnood, Babak</creator><creator>McDonnell, Bob</creator><creator>Mullaney, Carmel</creator><creator>Nelen, Vera</creator><creator>Randrianaivo, Hanitra</creator><creator>Rissmann, Anke</creator><creator>Salvador, Joaquin</creator><creator>Tucker, David</creator><creator>Wellesly, Diana</creator><creator>Rankin, Judith</creator><general>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>Epidemiology of small intestinal atresia in Europe: a register-based study</title><author>Best, Kate E ; Tennant, Peter W G ; Addor, Marie-Claude ; Bianchi, Fabrizio ; Boyd, Patricia ; Calzolari, Elisa ; Dias, Carlos Matias ; Doray, Berenice ; Draper, Elizabeth ; Garne, Ester ; Gatt, Miriam ; Greenlees, Ruth ; Haeusler, Martin ; Khoshnood, Babak ; McDonnell, Bob ; Mullaney, Carmel ; Nelen, Vera ; Randrianaivo, Hanitra ; Rissmann, Anke ; Salvador, Joaquin ; Tucker, David ; Wellesly, Diana ; Rankin, Judith</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b498t-9b4a168605e8e992784bccd3c778302d41ffa198f98d111cf7671cba20e84a803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age</topic><topic>Binomial distribution</topic><topic>Births</topic><topic>Duodenal Obstruction - congenital</topic><topic>Epidemiology</topic><topic>Europe - epidemiology</topic><topic>Female</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Intestinal Atresia - epidemiology</topic><topic>Intestine, Small - abnormalities</topic><topic>Karyotypes</topic><topic>Maternal Age</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Prevalence</topic><topic>Proportional Hazards Models</topic><topic>Registries</topic><topic>Studies</topic><topic>Survival analysis</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Best, Kate E</creatorcontrib><creatorcontrib>Tennant, Peter W G</creatorcontrib><creatorcontrib>Addor, Marie-Claude</creatorcontrib><creatorcontrib>Bianchi, Fabrizio</creatorcontrib><creatorcontrib>Boyd, Patricia</creatorcontrib><creatorcontrib>Calzolari, Elisa</creatorcontrib><creatorcontrib>Dias, Carlos Matias</creatorcontrib><creatorcontrib>Doray, Berenice</creatorcontrib><creatorcontrib>Draper, Elizabeth</creatorcontrib><creatorcontrib>Garne, Ester</creatorcontrib><creatorcontrib>Gatt, Miriam</creatorcontrib><creatorcontrib>Greenlees, Ruth</creatorcontrib><creatorcontrib>Haeusler, Martin</creatorcontrib><creatorcontrib>Khoshnood, Babak</creatorcontrib><creatorcontrib>McDonnell, Bob</creatorcontrib><creatorcontrib>Mullaney, Carmel</creatorcontrib><creatorcontrib>Nelen, Vera</creatorcontrib><creatorcontrib>Randrianaivo, Hanitra</creatorcontrib><creatorcontrib>Rissmann, Anke</creatorcontrib><creatorcontrib>Salvador, Joaquin</creatorcontrib><creatorcontrib>Tucker, David</creatorcontrib><creatorcontrib>Wellesly, Diana</creatorcontrib><creatorcontrib>Rankin, Judith</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Best, Kate E</au><au>Tennant, Peter W G</au><au>Addor, Marie-Claude</au><au>Bianchi, Fabrizio</au><au>Boyd, Patricia</au><au>Calzolari, Elisa</au><au>Dias, Carlos Matias</au><au>Doray, Berenice</au><au>Draper, Elizabeth</au><au>Garne, Ester</au><au>Gatt, Miriam</au><au>Greenlees, Ruth</au><au>Haeusler, Martin</au><au>Khoshnood, Babak</au><au>McDonnell, Bob</au><au>Mullaney, Carmel</au><au>Nelen, Vera</au><au>Randrianaivo, Hanitra</au><au>Rissmann, Anke</au><au>Salvador, Joaquin</au><au>Tucker, David</au><au>Wellesly, Diana</au><au>Rankin, Judith</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of small intestinal atresia in Europe: a register-based study</atitle><jtitle>Archives of disease in childhood. Fetal and neonatal edition</jtitle><addtitle>Arch Dis Child Fetal Neonatal Ed</addtitle><date>2012-09</date><risdate>2012</risdate><volume>97</volume><issue>5</issue><spage>F353</spage><epage>F358</epage><pages>F353-F358</pages><issn>1359-2998</issn><eissn>1468-2052</eissn><abstract>Background The epidemiology of congenital small intestinal atresia (SIA) has not been well studied. This study describes the presence of additional anomalies, pregnancy outcomes, total prevalence and association with maternal age in SIA cases in Europe. Methods Cases of SIA delivered during January 1990 to December 2006 notified to 20 EUROCAT registers formed the population-based case series. Prevalence over time was estimated using multilevel Poisson regression, and heterogeneity between registers was evaluated from the random component of the intercept. Results In total 1133 SIA cases were reported among 5126, 164 registered births. Of 1044 singleton cases, 215 (20.6%) cases were associated with a chromosomal anomaly. Of 829 singleton SIA cases with normal karyotype, 221 (26.7%) were associated with other structural anomalies. Considering cases with normal karyotype, the total prevalence per 10 000 births was 1.6 (95% CI 1.5 to 1.7) for SIA, 0.9 (95% CI 0.8 to 1.0) for duodenal atresia and 0.7 (95% CI 0.7 to 0.8) for jejunoileal atresia (JIA). There was no significant trend in SIA, duodenal atresia or JIA prevalence over time (RR=1.0, 95% credible interval (CrI): 1.0 to 1.0 for each), but SIA and duodenal atresia prevalence varied by geographical location (p=0.03 and p=0.04, respectively). There was weak evidence of an increased risk of SIA in mothers aged less than 20 years compared with mothers aged 20 to 29 years (RR=1.3, 95% CrI: 1.0 to 1.8). Conclusion This study found no evidence of a temporal trend in the prevalence of SIA, duodenal atresia or JIA, although SIA and duodenal atresia prevalence varied significantly between registers.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health</pub><pmid>22933095</pmid><doi>10.1136/fetalneonatal-2011-300631</doi></addata></record> |
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| ispartof | Archives of disease in childhood. Fetal and neonatal edition, 2012-09, Vol.97 (5), p.F353-F358 |
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| subjects | Age Binomial distribution Births Duodenal Obstruction - congenital Epidemiology Europe - epidemiology Female Heterogeneity Humans Intestinal Atresia - epidemiology Intestine, Small - abnormalities Karyotypes Maternal Age Population Pregnancy Pregnancy Outcome Prevalence Proportional Hazards Models Registries Studies Survival analysis Trends |
| title | Epidemiology of small intestinal atresia in Europe: a register-based study |
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