Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse
Summary Background cis‐Urocanic acid (cis‐UCA) is an endogenous immunosuppressive molecule of the epidermis. Objectives We investigated the effects of topical cis‐UCA creams (2·5% and 5%) in acute and subacute mouse models of skin inflammation. Methods Acute skin irritation was induced by applyin...
Gespeichert in:
| Veröffentlicht in: | British journal of dermatology (1951) 2012-09, Vol.167 (3), p.506-513 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 513 |
|---|---|
| container_issue | 3 |
| container_start_page | 506 |
| container_title | British journal of dermatology (1951) |
| container_volume | 167 |
| creator | Laihia, J.K. Taimen, P. Kujari, H. Leino, L. |
| description | Summary
Background cis‐Urocanic acid (cis‐UCA) is an endogenous immunosuppressive molecule of the epidermis.
Objectives We investigated the effects of topical cis‐UCA creams (2·5% and 5%) in acute and subacute mouse models of skin inflammation.
Methods Acute skin irritation was induced by applying dimethyl sulphoxide (DMSO) on the earlobe of CD‐1 mice. Topical cis‐UCA, hydrocortisone (1%) or tacrolimus (0·1%) were applied 10 min later. In another model, subacute inflammation was provoked and maintained by three applications of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) on the ears of NMRI mice on days 1, 2 and 4. The test products were applied topically twice a day during 6 days.
Results In the acute DMSO model, cis‐UCA creams suppressed ear swelling at 1 h significantly more efficiently than hydrocortisone (P |
| doi_str_mv | 10.1111/j.1365-2133.2012.11026.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1036880847</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1036880847</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3896-751cf45f41cced5b9450fb355fe4a4084e8c50df429f68779b6c004a4de1ed2f3</originalsourceid><addsrcrecordid>eNpFkVtv1DAQhS0EokvhLyC_IPGSZRzfkhckKFBataVCi3i0HGcsvM1lGydi99_j7G4Xv9hn5vPRaA4hlMGSpfNhvWRcySxnnC9zYHmqQq6W22dkcWo8JwsA0BmUip-RVzGuARgHCS_JWZ5LAbwoF6Rd9ZvgbENdiNk09M52wVHrQk3tOGI32REj7bHG1lLb1RSH3fhnFqFL2DTivhqn6iDiQ6qHzje2be0Y-lnQ9IG2_RTxNXnhbRPxzfE-J7--fV1dfM9uflxeXXy6yVwaSmVaMueF9II5h7WsSiHBV1xKj8IKKAQWTkLtRV56VWhdVsoBpFaNDOvc83Py_uC7GfrHCeNo2hAdNo3tMM1hGHBVFMlIJ_TtEZ2qFmuzGUJrh515WlEC3h0BG9Oi_GC7tKv_nOJalMAT9_HA_Q0N7k59BmaOzKzNnIyZkzFzZGYfmdmaz9df9s9kkB0MQhxxezKww4NRmmtpft9dmp8lv7-_vV4Zzf8Btq2ZWg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1036880847</pqid></control><display><type>article</type><title>Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Laihia, J.K. ; Taimen, P. ; Kujari, H. ; Leino, L.</creator><creatorcontrib>Laihia, J.K. ; Taimen, P. ; Kujari, H. ; Leino, L.</creatorcontrib><description>Summary
Background cis‐Urocanic acid (cis‐UCA) is an endogenous immunosuppressive molecule of the epidermis.
Objectives We investigated the effects of topical cis‐UCA creams (2·5% and 5%) in acute and subacute mouse models of skin inflammation.
Methods Acute skin irritation was induced by applying dimethyl sulphoxide (DMSO) on the earlobe of CD‐1 mice. Topical cis‐UCA, hydrocortisone (1%) or tacrolimus (0·1%) were applied 10 min later. In another model, subacute inflammation was provoked and maintained by three applications of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) on the ears of NMRI mice on days 1, 2 and 4. The test products were applied topically twice a day during 6 days.
Results In the acute DMSO model, cis‐UCA creams suppressed ear swelling at 1 h significantly more efficiently than hydrocortisone (P < 0·01) and tacrolimus (P < 0·001). Ear swelling was significantly inhibited by cis‐UCA (P < 0·001) in the subacute TPA model as well. The 5% cream also decreased erythema, whereas tacrolimus enhanced skin reddening. Treatments with cis‐UCA did not affect TPA‐induced infiltration of neutrophils to the skin. In contrast to hydrocortisone, cis‐UCA did not reduce epidermal thickness.
Conclusions The results suggest that cis‐UCA – unlike hydrocortisone and tacrolimus – is efficient in both acute and subacute skin inflammation, attenuating skin oedema and erythema. Topical drug therapy with cis‐UCA may provide a safe and effective drug treatment modality in inflammatory skin disorders.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2012.11026.x</identifier><identifier>PMID: 22540389</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; Administration, Cutaneous ; Animals ; Biological and medical sciences ; Dermatologic Agents - administration & dosage ; Dermatologic Agents - pharmacology ; Dermatology ; Dimethyl Sulfoxide - toxicity ; Drug Eruptions - drug therapy ; Drug Eruptions - etiology ; Edema - drug therapy ; Erythema - drug therapy ; Irritants - toxicity ; Male ; Medical sciences ; Mice ; Neutrophil Infiltration - drug effects ; Skin involvement in other diseases. Miscellaneous. General aspects ; Tetradecanoylphorbol Acetate - analogs & derivatives ; Tetradecanoylphorbol Acetate - toxicity ; Urocanic Acid - administration & dosage ; Urocanic Acid - pharmacology</subject><ispartof>British journal of dermatology (1951), 2012-09, Vol.167 (3), p.506-513</ispartof><rights>2012 The Authors. BJD © 2012 British Association of Dermatologists</rights><rights>2015 INIST-CNRS</rights><rights>2012 The Authors. BJD © 2012 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3896-751cf45f41cced5b9450fb355fe4a4084e8c50df429f68779b6c004a4de1ed2f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2012.11026.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2012.11026.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26374903$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22540389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laihia, J.K.</creatorcontrib><creatorcontrib>Taimen, P.</creatorcontrib><creatorcontrib>Kujari, H.</creatorcontrib><creatorcontrib>Leino, L.</creatorcontrib><title>Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background cis‐Urocanic acid (cis‐UCA) is an endogenous immunosuppressive molecule of the epidermis.
Objectives We investigated the effects of topical cis‐UCA creams (2·5% and 5%) in acute and subacute mouse models of skin inflammation.
Methods Acute skin irritation was induced by applying dimethyl sulphoxide (DMSO) on the earlobe of CD‐1 mice. Topical cis‐UCA, hydrocortisone (1%) or tacrolimus (0·1%) were applied 10 min later. In another model, subacute inflammation was provoked and maintained by three applications of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) on the ears of NMRI mice on days 1, 2 and 4. The test products were applied topically twice a day during 6 days.
Results In the acute DMSO model, cis‐UCA creams suppressed ear swelling at 1 h significantly more efficiently than hydrocortisone (P < 0·01) and tacrolimus (P < 0·001). Ear swelling was significantly inhibited by cis‐UCA (P < 0·001) in the subacute TPA model as well. The 5% cream also decreased erythema, whereas tacrolimus enhanced skin reddening. Treatments with cis‐UCA did not affect TPA‐induced infiltration of neutrophils to the skin. In contrast to hydrocortisone, cis‐UCA did not reduce epidermal thickness.
Conclusions The results suggest that cis‐UCA – unlike hydrocortisone and tacrolimus – is efficient in both acute and subacute skin inflammation, attenuating skin oedema and erythema. Topical drug therapy with cis‐UCA may provide a safe and effective drug treatment modality in inflammatory skin disorders.</description><subject>Acute Disease</subject><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Dermatologic Agents - pharmacology</subject><subject>Dermatology</subject><subject>Dimethyl Sulfoxide - toxicity</subject><subject>Drug Eruptions - drug therapy</subject><subject>Drug Eruptions - etiology</subject><subject>Edema - drug therapy</subject><subject>Erythema - drug therapy</subject><subject>Irritants - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neutrophil Infiltration - drug effects</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><subject>Tetradecanoylphorbol Acetate - analogs & derivatives</subject><subject>Tetradecanoylphorbol Acetate - toxicity</subject><subject>Urocanic Acid - administration & dosage</subject><subject>Urocanic Acid - pharmacology</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkVtv1DAQhS0EokvhLyC_IPGSZRzfkhckKFBataVCi3i0HGcsvM1lGydi99_j7G4Xv9hn5vPRaA4hlMGSpfNhvWRcySxnnC9zYHmqQq6W22dkcWo8JwsA0BmUip-RVzGuARgHCS_JWZ5LAbwoF6Rd9ZvgbENdiNk09M52wVHrQk3tOGI32REj7bHG1lLb1RSH3fhnFqFL2DTivhqn6iDiQ6qHzje2be0Y-lnQ9IG2_RTxNXnhbRPxzfE-J7--fV1dfM9uflxeXXy6yVwaSmVaMueF9II5h7WsSiHBV1xKj8IKKAQWTkLtRV56VWhdVsoBpFaNDOvc83Py_uC7GfrHCeNo2hAdNo3tMM1hGHBVFMlIJ_TtEZ2qFmuzGUJrh515WlEC3h0BG9Oi_GC7tKv_nOJalMAT9_HA_Q0N7k59BmaOzKzNnIyZkzFzZGYfmdmaz9df9s9kkB0MQhxxezKww4NRmmtpft9dmp8lv7-_vV4Zzf8Btq2ZWg</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Laihia, J.K.</creator><creator>Taimen, P.</creator><creator>Kujari, H.</creator><creator>Leino, L.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse</title><author>Laihia, J.K. ; Taimen, P. ; Kujari, H. ; Leino, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3896-751cf45f41cced5b9450fb355fe4a4084e8c50df429f68779b6c004a4de1ed2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute Disease</topic><topic>Administration, Cutaneous</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Dermatologic Agents - pharmacology</topic><topic>Dermatology</topic><topic>Dimethyl Sulfoxide - toxicity</topic><topic>Drug Eruptions - drug therapy</topic><topic>Drug Eruptions - etiology</topic><topic>Edema - drug therapy</topic><topic>Erythema - drug therapy</topic><topic>Irritants - toxicity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neutrophil Infiltration - drug effects</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><topic>Tetradecanoylphorbol Acetate - analogs & derivatives</topic><topic>Tetradecanoylphorbol Acetate - toxicity</topic><topic>Urocanic Acid - administration & dosage</topic><topic>Urocanic Acid - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laihia, J.K.</creatorcontrib><creatorcontrib>Taimen, P.</creatorcontrib><creatorcontrib>Kujari, H.</creatorcontrib><creatorcontrib>Leino, L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laihia, J.K.</au><au>Taimen, P.</au><au>Kujari, H.</au><au>Leino, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2012-09</date><risdate>2012</risdate><volume>167</volume><issue>3</issue><spage>506</spage><epage>513</epage><pages>506-513</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary
Background cis‐Urocanic acid (cis‐UCA) is an endogenous immunosuppressive molecule of the epidermis.
Objectives We investigated the effects of topical cis‐UCA creams (2·5% and 5%) in acute and subacute mouse models of skin inflammation.
Methods Acute skin irritation was induced by applying dimethyl sulphoxide (DMSO) on the earlobe of CD‐1 mice. Topical cis‐UCA, hydrocortisone (1%) or tacrolimus (0·1%) were applied 10 min later. In another model, subacute inflammation was provoked and maintained by three applications of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) on the ears of NMRI mice on days 1, 2 and 4. The test products were applied topically twice a day during 6 days.
Results In the acute DMSO model, cis‐UCA creams suppressed ear swelling at 1 h significantly more efficiently than hydrocortisone (P < 0·01) and tacrolimus (P < 0·001). Ear swelling was significantly inhibited by cis‐UCA (P < 0·001) in the subacute TPA model as well. The 5% cream also decreased erythema, whereas tacrolimus enhanced skin reddening. Treatments with cis‐UCA did not affect TPA‐induced infiltration of neutrophils to the skin. In contrast to hydrocortisone, cis‐UCA did not reduce epidermal thickness.
Conclusions The results suggest that cis‐UCA – unlike hydrocortisone and tacrolimus – is efficient in both acute and subacute skin inflammation, attenuating skin oedema and erythema. Topical drug therapy with cis‐UCA may provide a safe and effective drug treatment modality in inflammatory skin disorders.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22540389</pmid><doi>10.1111/j.1365-2133.2012.11026.x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 2012-09, Vol.167 (3), p.506-513 |
| issn | 0007-0963 1365-2133 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1036880847 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acute Disease Administration, Cutaneous Animals Biological and medical sciences Dermatologic Agents - administration & dosage Dermatologic Agents - pharmacology Dermatology Dimethyl Sulfoxide - toxicity Drug Eruptions - drug therapy Drug Eruptions - etiology Edema - drug therapy Erythema - drug therapy Irritants - toxicity Male Medical sciences Mice Neutrophil Infiltration - drug effects Skin involvement in other diseases. Miscellaneous. General aspects Tetradecanoylphorbol Acetate - analogs & derivatives Tetradecanoylphorbol Acetate - toxicity Urocanic Acid - administration & dosage Urocanic Acid - pharmacology |
| title | Topical cis-urocanic acid attenuates oedema and erythema in acute and subacute skin inflammation in the mouse |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T14%3A35%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Topical%20cis-urocanic%20acid%20attenuates%20oedema%20and%20erythema%20in%20acute%20and%20subacute%20skin%20inflammation%20in%20the%20mouse&rft.jtitle=British%20journal%20of%20dermatology%20(1951)&rft.au=Laihia,%20J.K.&rft.date=2012-09&rft.volume=167&rft.issue=3&rft.spage=506&rft.epage=513&rft.pages=506-513&rft.issn=0007-0963&rft.eissn=1365-2133&rft.coden=BJDEAZ&rft_id=info:doi/10.1111/j.1365-2133.2012.11026.x&rft_dat=%3Cproquest_pubme%3E1036880847%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1036880847&rft_id=info:pmid/22540389&rfr_iscdi=true |