Globular adiponectin inhibits ethanol-induced apoptosis in HepG2 cells through heme oxygenase-1 induction

Hepatocellular apoptosis is an essential pathological feature of alcoholic liver disease. Adiponectin, an adipokine predominantly secreted from adipose tissue, has been shown to play beneficial roles in alcoholic liver disease against various inflammatory and pro-apoptotic molecules. However, the ef...

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Veröffentlicht in:	Biochemical pharmacology 2012-10, Vol.84 (7), p.974-983
Hauptverfasser:	Nepal, Saroj, Kim, Mi Jin, Subedi, Amit, Lee, Eung-Seok, Yong, Chul Soon, Kim, Jung-Ae, Kang, WonKu, Kwak, Mi-Kyung, Arya, Dharamvir Singh, Park, Pil-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Adiponectin - pharmacology adiponectin receptors adipose tissue alcohol drinking Apoptosis Apoptosis - drug effects Carbon Monoxide caspase-3 Enzyme Induction Ethanol Ethanol - toxicity Fas Ligand Protein - biosynthesis heme heme oxygenase (biliverdin-producing) Heme oxygenase-1 Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Hep G2 Cells hepatocytes hepatoma human cell lines Humans liver metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 pharmacology protective effect Receptors, Adiponectin - genetics Receptors, Adiponectin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction small interfering RNA
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