Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing MicroRNA-449 in Hepatocellular Carcinoma Cells

Background & Aims Histone deacetylation regulates chromatin remodeling and transcriptional down-regulation of specific genomic regions; it is altered in many types of cancer cells. We searched for microRNAs (miRs) that are affected by histone deacetylation and investigated the effects in hepatoc...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2012-09, Vol.143 (3), p.811-820.e15
Hauptverfasser:	Buurman, Reena, Gürlevik, Engin, Schäffer, Vera, Eilers, Marlies, Sandbothe, Maria, Kreipe, Hans, Wilkens, Ludwig, Schlegelberger, Brigitte, Kühnel, Florian, Skawran, Britta
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Apoptosis Binding Sites Blotting, Western Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Proliferation Gastroenterology and Hepatology Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes, Reporter HEK293 Cells Hep G2 Cells Hepatocyte Growth Factor - metabolism Histone Deacetylase 1 - metabolism Histone Deacetylase 2 - metabolism Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Hydroxamic Acids - pharmacology Liver Neoplasms - enzymology Liver Neoplasms - genetics Liver Neoplasms - pathology Mice Mice, Nude MicroRNAs - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Phosphorylation Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism RNA Interference RNA, Messenger - metabolism Signal Transduction - drug effects Time Factors Transfection Tumor Burden
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