Transient 100 nM Dexamethasone Treatment Reduces Inter- and Intraindividual Variations in Osteoblastic Differentiation of Bone Marrow-Derived Human Mesenchymal Stem Cells

The development of in vitro culturing techniques for osteoblastic differentiation of human mesenchymal stem cells (hMSC) is important for cell biology research and the development of tissue-engineering applications. Dexamethasone (Dex) is a commonly used supplement, but the optimal use of Dex treatm...

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Veröffentlicht in:	Tissue engineering. Part C, Methods Methods, 2012-09, Vol.18 (9), p.658-666
Hauptverfasser:	Alm, Jessica J., Heino, Terhi J., Hentunen, Teuvo A., Väänänen, H. Kalervo, Aro, Hannu T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alkaline Phosphatase - metabolism Apoptosis Bone marrow Bone Marrow Cells - cytology Cell Culture Techniques - methods Cell Differentiation Cell Proliferation Cell Survival Cellular biology Collagen Type I - metabolism Dexamethasone - pharmacology Female Glucocorticoids - pharmacology Humans Mesenchymal Stromal Cells - cytology Middle Aged Osteoblasts - cytology Osteoblasts - metabolism Osteocalcin - biosynthesis Stem cells Tissue engineering Tissue Engineering - methods
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