Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial

Summary Background Thrombolysis with intravenous alteplase is the only approved treatment for acute ischaemic stroke. After alteplase-induced recanalisation, reocclusion occurs in 14–34% of patients, probably because of platelet activation. Early administration of antiplatelet therapy after alteplas...

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Veröffentlicht in:	The Lancet (British edition) 2012-08, Vol.380 (9843), p.731-737
Hauptverfasser:	Zinkstok, Sanne M, MD, Roos, Yvo B, Dr
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aspirin - administration & dosage Aspirin - adverse effects Biological and medical sciences Blood clots Drug Administration Schedule Drug therapy Drug Therapy, Combination Early Termination of Clinical Trials Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - adverse effects General aspects Heart attacks Humans Infusions, Intravenous Internal Medicine Intracranial Hemorrhages - chemically induced Male Medical imaging Medical sciences Middle Aged Mortality Neurology Nurses Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Prospective Studies Risk reduction Secondary Prevention Stroke Stroke - drug therapy Stroke - mortality Teaching hospitals Time Factors Tissue Plasminogen Activator - administration & dosage Treatment Outcome Vascular diseases and vascular malformations of the nervous system
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