Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation
► NK cells are differentiated from hematopoietic stem cells. ► Tanshinones induce NK cell differentiation. ► Tanshinones activates p38 pathway. Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinon...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2012-08, Vol.425 (2), p.340-347 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Kim, Won Sam Kim, Dong Oh Yoon, Sung Jin Kim, Mi Jeong Yoon, Suk Ran Park, Young-Jun Jung, Haiyoung Kim, Tae-Don Kwon, Byoung-Mog Choi, Inpyo |
| description | ► NK cells are differentiated from hematopoietic stem cells. ► Tanshinones induce NK cell differentiation. ► Tanshinones activates p38 pathway.
Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells. In the presence of IL-15, tanshinones increased NK cell maturation, NK cell differentiation and the expression of several transcription factors, including Id2, GATA3, T-bet, and Ets-1. Additionally, tanshinones increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, the p38 inhibitor SB203580 blocked the developmental effects of the tanshinones and suppressed Id2, T-bet, and Ets-1 expression during NK cell differentiation. These results suggest that tanshinones significantly increased IL-15-induced NK cell differentiation via enhancing the p38 phosphorylation and the expression of transcription factors. |
| doi_str_mv | 10.1016/j.bbrc.2012.07.093 |
| format | Article |
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Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells. In the presence of IL-15, tanshinones increased NK cell maturation, NK cell differentiation and the expression of several transcription factors, including Id2, GATA3, T-bet, and Ets-1. Additionally, tanshinones increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, the p38 inhibitor SB203580 blocked the developmental effects of the tanshinones and suppressed Id2, T-bet, and Ets-1 expression during NK cell differentiation. These results suggest that tanshinones significantly increased IL-15-induced NK cell differentiation via enhancing the p38 phosphorylation and the expression of transcription factors.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2012.07.093</identifier><identifier>PMID: 22842576</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Cell Differentiation - drug effects ; Cell Differentiation - immunology ; Cryptotanshinone ; Differentiation ; Diterpenes, Abietane - pharmacology ; Drugs, Chinese Herbal - pharmacology ; Id2 ; Imidazoles - pharmacology ; Interleukin-15 - pharmacology ; Killer Cells, Natural - cytology ; Killer Cells, Natural - drug effects ; Killer Cells, Natural - immunology ; Lymphocyte Subsets - cytology ; Lymphocyte Subsets - drug effects ; Lymphocyte Subsets - immunology ; Mice ; Mice, Inbred C57BL ; NK cells ; p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors ; p38 Mitogen-Activated Protein Kinases - metabolism ; Phenanthrenes - pharmacology ; Phosphorylation ; Pyridines - pharmacology ; Tanshinone IIA ; Transcription Factors - genetics</subject><ispartof>Biochemical and biophysical research communications, 2012-08, Vol.425 (2), p.340-347</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-cbec1d11bfda7cffcc0aec91a6080bda207740871cd5fc6c27248705387049693</citedby><cites>FETCH-LOGICAL-c356t-cbec1d11bfda7cffcc0aec91a6080bda207740871cd5fc6c27248705387049693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X12014003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22842576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Won Sam</creatorcontrib><creatorcontrib>Kim, Dong Oh</creatorcontrib><creatorcontrib>Yoon, Sung Jin</creatorcontrib><creatorcontrib>Kim, Mi Jeong</creatorcontrib><creatorcontrib>Yoon, Suk Ran</creatorcontrib><creatorcontrib>Park, Young-Jun</creatorcontrib><creatorcontrib>Jung, Haiyoung</creatorcontrib><creatorcontrib>Kim, Tae-Don</creatorcontrib><creatorcontrib>Kwon, Byoung-Mog</creatorcontrib><creatorcontrib>Choi, Inpyo</creatorcontrib><title>Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>► NK cells are differentiated from hematopoietic stem cells. ► Tanshinones induce NK cell differentiation. ► Tanshinones activates p38 pathway.
Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells. In the presence of IL-15, tanshinones increased NK cell maturation, NK cell differentiation and the expression of several transcription factors, including Id2, GATA3, T-bet, and Ets-1. Additionally, tanshinones increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, the p38 inhibitor SB203580 blocked the developmental effects of the tanshinones and suppressed Id2, T-bet, and Ets-1 expression during NK cell differentiation. These results suggest that tanshinones significantly increased IL-15-induced NK cell differentiation via enhancing the p38 phosphorylation and the expression of transcription factors.</description><subject>Animals</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - immunology</subject><subject>Cryptotanshinone</subject><subject>Differentiation</subject><subject>Diterpenes, Abietane - pharmacology</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Id2</subject><subject>Imidazoles - pharmacology</subject><subject>Interleukin-15 - pharmacology</subject><subject>Killer Cells, Natural - cytology</subject><subject>Killer Cells, Natural - drug effects</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocyte Subsets - cytology</subject><subject>Lymphocyte Subsets - drug effects</subject><subject>Lymphocyte Subsets - immunology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>NK cells</subject><subject>p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><subject>Phenanthrenes - pharmacology</subject><subject>Phosphorylation</subject><subject>Pyridines - pharmacology</subject><subject>Tanshinone IIA</subject><subject>Transcription Factors - genetics</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9r2zAUx8VoWdJs_8AOw8de7D3JthTDLiV0bSDQSwu9FCE_PRNljpxJ9iD__RSSjp120Q_4fL-892HsC4eCA5ffdkXbBiwEcFGAKqApP7A5hwZywaG6YnMAkLlo-OuM3cS4A-C8ks1HNhNiWYlayTl7W4XjYRxG4-PW-cFTZrzN_vmu13cZ-a3xmN6bnNe583ZCspk34xRMn_10fU8hQ-r7zLquo0B-dGZ0g__ErjvTR_p8uRfs5cf98-ox3zw9rFd3mxzLWo45toTcct521ijsOkQwhA03EpbQWiNAqQqWiqOtO5QolKiWCuoyHVUjm3LBbs-9hzD8miiOeu_iaSDjaZii5lDWtWhAyISKM4phiDFQpw_B7U04JkiftOqdPmnVJ60alE5aU-jrpX9q92T_Rt49JuD7GaC05W9HQUd0lJxZFwhHbQf3v_4_iTmJZw</recordid><startdate>20120824</startdate><enddate>20120824</enddate><creator>Kim, Won Sam</creator><creator>Kim, Dong Oh</creator><creator>Yoon, Sung Jin</creator><creator>Kim, Mi Jeong</creator><creator>Yoon, Suk Ran</creator><creator>Park, Young-Jun</creator><creator>Jung, Haiyoung</creator><creator>Kim, Tae-Don</creator><creator>Kwon, Byoung-Mog</creator><creator>Choi, Inpyo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120824</creationdate><title>Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation</title><author>Kim, Won Sam ; Kim, Dong Oh ; Yoon, Sung Jin ; Kim, Mi Jeong ; Yoon, Suk Ran ; Park, Young-Jun ; Jung, Haiyoung ; Kim, Tae-Don ; Kwon, Byoung-Mog ; Choi, Inpyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-cbec1d11bfda7cffcc0aec91a6080bda207740871cd5fc6c27248705387049693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Differentiation - immunology</topic><topic>Cryptotanshinone</topic><topic>Differentiation</topic><topic>Diterpenes, Abietane - pharmacology</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Id2</topic><topic>Imidazoles - pharmacology</topic><topic>Interleukin-15 - pharmacology</topic><topic>Killer Cells, Natural - cytology</topic><topic>Killer Cells, Natural - drug effects</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lymphocyte Subsets - cytology</topic><topic>Lymphocyte Subsets - drug effects</topic><topic>Lymphocyte Subsets - immunology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>NK cells</topic><topic>p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>Phenanthrenes - pharmacology</topic><topic>Phosphorylation</topic><topic>Pyridines - pharmacology</topic><topic>Tanshinone IIA</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Won Sam</creatorcontrib><creatorcontrib>Kim, Dong Oh</creatorcontrib><creatorcontrib>Yoon, Sung Jin</creatorcontrib><creatorcontrib>Kim, Mi Jeong</creatorcontrib><creatorcontrib>Yoon, Suk Ran</creatorcontrib><creatorcontrib>Park, Young-Jun</creatorcontrib><creatorcontrib>Jung, Haiyoung</creatorcontrib><creatorcontrib>Kim, Tae-Don</creatorcontrib><creatorcontrib>Kwon, Byoung-Mog</creatorcontrib><creatorcontrib>Choi, Inpyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Won Sam</au><au>Kim, Dong Oh</au><au>Yoon, Sung Jin</au><au>Kim, Mi Jeong</au><au>Yoon, Suk Ran</au><au>Park, Young-Jun</au><au>Jung, Haiyoung</au><au>Kim, Tae-Don</au><au>Kwon, Byoung-Mog</au><au>Choi, Inpyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2012-08-24</date><risdate>2012</risdate><volume>425</volume><issue>2</issue><spage>340</spage><epage>347</epage><pages>340-347</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>► NK cells are differentiated from hematopoietic stem cells. ► Tanshinones induce NK cell differentiation. ► Tanshinones activates p38 pathway.
Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells. In the presence of IL-15, tanshinones increased NK cell maturation, NK cell differentiation and the expression of several transcription factors, including Id2, GATA3, T-bet, and Ets-1. Additionally, tanshinones increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, the p38 inhibitor SB203580 blocked the developmental effects of the tanshinones and suppressed Id2, T-bet, and Ets-1 expression during NK cell differentiation. These results suggest that tanshinones significantly increased IL-15-induced NK cell differentiation via enhancing the p38 phosphorylation and the expression of transcription factors.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22842576</pmid><doi>10.1016/j.bbrc.2012.07.093</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Cell Differentiation - drug effects Cell Differentiation - immunology Cryptotanshinone Differentiation Diterpenes, Abietane - pharmacology Drugs, Chinese Herbal - pharmacology Id2 Imidazoles - pharmacology Interleukin-15 - pharmacology Killer Cells, Natural - cytology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lymphocyte Subsets - cytology Lymphocyte Subsets - drug effects Lymphocyte Subsets - immunology Mice Mice, Inbred C57BL NK cells p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phenanthrenes - pharmacology Phosphorylation Pyridines - pharmacology Tanshinone IIA Transcription Factors - genetics |
| title | Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation |
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