Effect of immunomodulatory therapy on the endometrial inflammatory response to induced infectious endometritis in susceptible mares

The objective of the present study was to evaluate the effect of immunomodulatory therapy (glucocorticoids (GC) and mycobacterium cell wall extract (MCWE)) on the endometrial gene expression of inflammatory cytokines in susceptible mares with induced infectious endometritis. Endometrial gene express...

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Veröffentlicht in:	Theriogenology 2012-09, Vol.78 (5), p.991-1004
Hauptverfasser:	Christoffersen, M, Woodward, E.M, Bojesen, A.M, Petersen, M.R, Squires, E.L, Lehn-Jensen, H, Troedsson, M.H.T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonists Anti-Inflammatory Agents - therapeutic use cell walls Cytokines - genetics Cytokines - metabolism dexamethasone Dexamethasone - therapeutic use endometritis Endometritis - drug therapy Endometritis - metabolism Endometritis - microbiology Endometritis - veterinary Endometrium - drug effects Endometrium - metabolism Endometrium - pathology Escherichia coli Escherichia coli Infections - drug therapy Escherichia coli Infections - pathology Escherichia coli Infections - veterinary Estrous Cycle experimental design Female gene expression Gene Expression Regulation - drug effects Gene Expression Regulation - physiology glucocorticoids histopathology Horse Diseases - drug therapy Horse Diseases - immunology Horse Diseases - metabolism Horse Diseases - pathology Horses immunity Immunomodulatory therapy Infectious endometritis inflammation Inflammatory cytokines interleukin-1 interleukin-10 interleukin-6 interleukin-8 mares Mycobacterium - chemistry necrosis pathogens polymerase chain reaction Reverse Transcriptase Polymerase Chain Reaction RNA-directed DNA polymerase Serum amyloid A therapeutics tumor necrosis factors
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