Vitamin D Deficiency may be an Independent Risk Factor for Arterial Disease
Abstract Objectives The aim of this study was to assess the vitamin D status in patients with occlusive or aneurysmatic arterial disease in relation to clinical cardiovascular risk profiles and markers of atherosclerotic disease. Methods We included 490 patients with symptomatic peripheral arterial...
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| Veröffentlicht in: | European journal of vascular and endovascular surgery 2012-09, Vol.44 (3), p.301-306 |
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| creator | van de Luijtgaarden, K.M Voûte, M.T Hoeks, S.E Bakker, E.J Chonchol, M Stolker, R.J Rouwet, E.V Verhagen, H.J.M |
| description | Abstract Objectives The aim of this study was to assess the vitamin D status in patients with occlusive or aneurysmatic arterial disease in relation to clinical cardiovascular risk profiles and markers of atherosclerotic disease. Methods We included 490 patients with symptomatic peripheral arterial disease (PAD, n = 254) or aortic aneurysm ( n = 236). Cardiovascular risk factors and comorbidities carotid intima–media thickness (CIMT), ankle–brachial index (ABI), serum high-sensitive C-reactive protein (hs-CRP) and vitamin D were assessed. Patients were categorised into severely (≤25 nmol l−1 ) or moderately (26–50 nmol l−1 ) vitamin D deficient, vitamin D insufficient (51–75 nmol l−1 ) or vitamin D sufficient (>75 nmol l−1 ). Results Overall, 45% of patients suffered from moderate or severe vitamin D deficiency. The prevalence of vitamin D deficiency was similar in patients with PAD and those with an aortic aneurysm. Low levels of vitamin D were associated with congestive heart failure and cerebrovascular disease. Adjusting for clinical cardiovascular risk factors, multivariable regression analyses showed that low vitamin D status was associated with higher CIMT ( P = 0.001), lower ABI ( P |
| doi_str_mv | 10.1016/j.ejvs.2012.06.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1035107786</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1078588412004297</els_id><sourcerecordid>1035107786</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-329a5b1351a5e71ae27e2f773bcdcd251a0ab567a39d8e0b9aebd3e83203ea023</originalsourceid><addsrcrecordid>eNp9kU9P3DAQxS1EBRT4AhyQj1ySju11nJUQEmJLi4pUqbRcrYkzkRzyZ7GzSPvt67DAoYcePLZG7z2Nf8PYmYBcgCi-tDm1LzGXIGQORQ7C7LEjoZXMpCj0fnqDKTNdlotD9jnGFgC0UPqAHUpZLoQq4Ij9ePQT9n7gK76ixjtPg9vyHre8Io4DvxtqWlMqw8R_-fjEb9FNY-BNOtdhouCx4ysfCSOdsE8NdpFO3-5j9uf26--b79n9z293N9f3mVtoPWVKLlFXaRCBmoxAkoZkY4yqXO1qmdqAlS4MqmVdElRLpKpWVCoJihCkOmYXu9x1GJ83FCfb--io63CgcROtgJQNxpRFksqd1IUxxkCNXQffY9gmkZ0h2tbOEO0M0UJhE8RkOn_L31Q91R-Wd2pJcLkTUPrli6dg4ys4qn0gN9l69P_Pv_rH7jo_eIfdE20ptuMmDImfFTYmj32Y1zhvUUiAhVwa9Rcpf5bS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1035107786</pqid></control><display><type>article</type><title>Vitamin D Deficiency may be an Independent Risk Factor for Arterial Disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>van de Luijtgaarden, K.M ; Voûte, M.T ; Hoeks, S.E ; Bakker, E.J ; Chonchol, M ; Stolker, R.J ; Rouwet, E.V ; Verhagen, H.J.M</creator><creatorcontrib>van de Luijtgaarden, K.M ; Voûte, M.T ; Hoeks, S.E ; Bakker, E.J ; Chonchol, M ; Stolker, R.J ; Rouwet, E.V ; Verhagen, H.J.M</creatorcontrib><description>Abstract Objectives The aim of this study was to assess the vitamin D status in patients with occlusive or aneurysmatic arterial disease in relation to clinical cardiovascular risk profiles and markers of atherosclerotic disease. Methods We included 490 patients with symptomatic peripheral arterial disease (PAD, n = 254) or aortic aneurysm ( n = 236). Cardiovascular risk factors and comorbidities carotid intima–media thickness (CIMT), ankle–brachial index (ABI), serum high-sensitive C-reactive protein (hs-CRP) and vitamin D were assessed. Patients were categorised into severely (≤25 nmol l−1 ) or moderately (26–50 nmol l−1 ) vitamin D deficient, vitamin D insufficient (51–75 nmol l−1 ) or vitamin D sufficient (>75 nmol l−1 ). Results Overall, 45% of patients suffered from moderate or severe vitamin D deficiency. The prevalence of vitamin D deficiency was similar in patients with PAD and those with an aortic aneurysm. Low levels of vitamin D were associated with congestive heart failure and cerebrovascular disease. Adjusting for clinical cardiovascular risk factors, multivariable regression analyses showed that low vitamin D status was associated with higher CIMT ( P = 0.001), lower ABI ( P < 0.001) and higher hs-CRP ( P = 0.022). Conclusions The current study shows a strong association between low vitamin D status and arterial disease, independent of traditional cardiovascular risk factors and irrespective of the type of vascular disease, that is, occlusive or aneurysmatic disease.</description><identifier>ISSN: 1078-5884</identifier><identifier>EISSN: 1532-2165</identifier><identifier>DOI: 10.1016/j.ejvs.2012.06.017</identifier><identifier>PMID: 22841360</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Aneurysm ; Ankle Brachial Index ; Aortic Aneurysm - blood ; Aortic Aneurysm - diagnosis ; Aortic Aneurysm - epidemiology ; Biomarkers - blood ; C-Reactive Protein - analysis ; Cardiovascular disease ; Carotid Intima-Media Thickness ; Comorbidity ; Female ; Humans ; Linear Models ; Male ; Middle Aged ; Multivariate Analysis ; Netherlands - epidemiology ; Peripheral arterial disease ; Peripheral Arterial Disease - blood ; Peripheral Arterial Disease - diagnosis ; Peripheral Arterial Disease - epidemiology ; Prevalence ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Surgery ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D deficiency ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - diagnosis ; Vitamin D Deficiency - epidemiology</subject><ispartof>European journal of vascular and endovascular surgery, 2012-09, Vol.44 (3), p.301-306</ispartof><rights>2012</rights><rights>Copyright © 2012. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-329a5b1351a5e71ae27e2f773bcdcd251a0ab567a39d8e0b9aebd3e83203ea023</citedby><cites>FETCH-LOGICAL-c455t-329a5b1351a5e71ae27e2f773bcdcd251a0ab567a39d8e0b9aebd3e83203ea023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1078588412004297$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22841360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van de Luijtgaarden, K.M</creatorcontrib><creatorcontrib>Voûte, M.T</creatorcontrib><creatorcontrib>Hoeks, S.E</creatorcontrib><creatorcontrib>Bakker, E.J</creatorcontrib><creatorcontrib>Chonchol, M</creatorcontrib><creatorcontrib>Stolker, R.J</creatorcontrib><creatorcontrib>Rouwet, E.V</creatorcontrib><creatorcontrib>Verhagen, H.J.M</creatorcontrib><title>Vitamin D Deficiency may be an Independent Risk Factor for Arterial Disease</title><title>European journal of vascular and endovascular surgery</title><addtitle>Eur J Vasc Endovasc Surg</addtitle><description>Abstract Objectives The aim of this study was to assess the vitamin D status in patients with occlusive or aneurysmatic arterial disease in relation to clinical cardiovascular risk profiles and markers of atherosclerotic disease. Methods We included 490 patients with symptomatic peripheral arterial disease (PAD, n = 254) or aortic aneurysm ( n = 236). Cardiovascular risk factors and comorbidities carotid intima–media thickness (CIMT), ankle–brachial index (ABI), serum high-sensitive C-reactive protein (hs-CRP) and vitamin D were assessed. Patients were categorised into severely (≤25 nmol l−1 ) or moderately (26–50 nmol l−1 ) vitamin D deficient, vitamin D insufficient (51–75 nmol l−1 ) or vitamin D sufficient (>75 nmol l−1 ). Results Overall, 45% of patients suffered from moderate or severe vitamin D deficiency. The prevalence of vitamin D deficiency was similar in patients with PAD and those with an aortic aneurysm. Low levels of vitamin D were associated with congestive heart failure and cerebrovascular disease. Adjusting for clinical cardiovascular risk factors, multivariable regression analyses showed that low vitamin D status was associated with higher CIMT ( P = 0.001), lower ABI ( P < 0.001) and higher hs-CRP ( P = 0.022). Conclusions The current study shows a strong association between low vitamin D status and arterial disease, independent of traditional cardiovascular risk factors and irrespective of the type of vascular disease, that is, occlusive or aneurysmatic disease.</description><subject>Aged</subject><subject>Aneurysm</subject><subject>Ankle Brachial Index</subject><subject>Aortic Aneurysm - blood</subject><subject>Aortic Aneurysm - diagnosis</subject><subject>Aortic Aneurysm - epidemiology</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular disease</subject><subject>Carotid Intima-Media Thickness</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Netherlands - epidemiology</subject><subject>Peripheral arterial disease</subject><subject>Peripheral Arterial Disease - blood</subject><subject>Peripheral Arterial Disease - diagnosis</subject><subject>Peripheral Arterial Disease - epidemiology</subject><subject>Prevalence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Surgery</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D deficiency</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - diagnosis</subject><subject>Vitamin D Deficiency - epidemiology</subject><issn>1078-5884</issn><issn>1532-2165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9P3DAQxS1EBRT4AhyQj1ySju11nJUQEmJLi4pUqbRcrYkzkRzyZ7GzSPvt67DAoYcePLZG7z2Nf8PYmYBcgCi-tDm1LzGXIGQORQ7C7LEjoZXMpCj0fnqDKTNdlotD9jnGFgC0UPqAHUpZLoQq4Ij9ePQT9n7gK76ixjtPg9vyHre8Io4DvxtqWlMqw8R_-fjEb9FNY-BNOtdhouCx4ysfCSOdsE8NdpFO3-5j9uf26--b79n9z293N9f3mVtoPWVKLlFXaRCBmoxAkoZkY4yqXO1qmdqAlS4MqmVdElRLpKpWVCoJihCkOmYXu9x1GJ83FCfb--io63CgcROtgJQNxpRFksqd1IUxxkCNXQffY9gmkZ0h2tbOEO0M0UJhE8RkOn_L31Q91R-Wd2pJcLkTUPrli6dg4ys4qn0gN9l69P_Pv_rH7jo_eIfdE20ptuMmDImfFTYmj32Y1zhvUUiAhVwa9Rcpf5bS</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>van de Luijtgaarden, K.M</creator><creator>Voûte, M.T</creator><creator>Hoeks, S.E</creator><creator>Bakker, E.J</creator><creator>Chonchol, M</creator><creator>Stolker, R.J</creator><creator>Rouwet, E.V</creator><creator>Verhagen, H.J.M</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Vitamin D Deficiency may be an Independent Risk Factor for Arterial Disease</title><author>van de Luijtgaarden, K.M ; Voûte, M.T ; Hoeks, S.E ; Bakker, E.J ; Chonchol, M ; Stolker, R.J ; Rouwet, E.V ; Verhagen, H.J.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-329a5b1351a5e71ae27e2f773bcdcd251a0ab567a39d8e0b9aebd3e83203ea023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aneurysm</topic><topic>Ankle Brachial Index</topic><topic>Aortic Aneurysm - blood</topic><topic>Aortic Aneurysm - diagnosis</topic><topic>Aortic Aneurysm - epidemiology</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiovascular disease</topic><topic>Carotid Intima-Media Thickness</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Netherlands - epidemiology</topic><topic>Peripheral arterial disease</topic><topic>Peripheral Arterial Disease - blood</topic><topic>Peripheral Arterial Disease - diagnosis</topic><topic>Peripheral Arterial Disease - epidemiology</topic><topic>Prevalence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Surgery</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D deficiency</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - diagnosis</topic><topic>Vitamin D Deficiency - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van de Luijtgaarden, K.M</creatorcontrib><creatorcontrib>Voûte, M.T</creatorcontrib><creatorcontrib>Hoeks, S.E</creatorcontrib><creatorcontrib>Bakker, E.J</creatorcontrib><creatorcontrib>Chonchol, M</creatorcontrib><creatorcontrib>Stolker, R.J</creatorcontrib><creatorcontrib>Rouwet, E.V</creatorcontrib><creatorcontrib>Verhagen, H.J.M</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of vascular and endovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van de Luijtgaarden, K.M</au><au>Voûte, M.T</au><au>Hoeks, S.E</au><au>Bakker, E.J</au><au>Chonchol, M</au><au>Stolker, R.J</au><au>Rouwet, E.V</au><au>Verhagen, H.J.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D Deficiency may be an Independent Risk Factor for Arterial Disease</atitle><jtitle>European journal of vascular and endovascular surgery</jtitle><addtitle>Eur J Vasc Endovasc Surg</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>44</volume><issue>3</issue><spage>301</spage><epage>306</epage><pages>301-306</pages><issn>1078-5884</issn><eissn>1532-2165</eissn><abstract>Abstract Objectives The aim of this study was to assess the vitamin D status in patients with occlusive or aneurysmatic arterial disease in relation to clinical cardiovascular risk profiles and markers of atherosclerotic disease. Methods We included 490 patients with symptomatic peripheral arterial disease (PAD, n = 254) or aortic aneurysm ( n = 236). Cardiovascular risk factors and comorbidities carotid intima–media thickness (CIMT), ankle–brachial index (ABI), serum high-sensitive C-reactive protein (hs-CRP) and vitamin D were assessed. Patients were categorised into severely (≤25 nmol l−1 ) or moderately (26–50 nmol l−1 ) vitamin D deficient, vitamin D insufficient (51–75 nmol l−1 ) or vitamin D sufficient (>75 nmol l−1 ). Results Overall, 45% of patients suffered from moderate or severe vitamin D deficiency. The prevalence of vitamin D deficiency was similar in patients with PAD and those with an aortic aneurysm. Low levels of vitamin D were associated with congestive heart failure and cerebrovascular disease. Adjusting for clinical cardiovascular risk factors, multivariable regression analyses showed that low vitamin D status was associated with higher CIMT ( P = 0.001), lower ABI ( P < 0.001) and higher hs-CRP ( P = 0.022). Conclusions The current study shows a strong association between low vitamin D status and arterial disease, independent of traditional cardiovascular risk factors and irrespective of the type of vascular disease, that is, occlusive or aneurysmatic disease.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>22841360</pmid><doi>10.1016/j.ejvs.2012.06.017</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aneurysm Ankle Brachial Index Aortic Aneurysm - blood Aortic Aneurysm - diagnosis Aortic Aneurysm - epidemiology Biomarkers - blood C-Reactive Protein - analysis Cardiovascular disease Carotid Intima-Media Thickness Comorbidity Female Humans Linear Models Male Middle Aged Multivariate Analysis Netherlands - epidemiology Peripheral arterial disease Peripheral Arterial Disease - blood Peripheral Arterial Disease - diagnosis Peripheral Arterial Disease - epidemiology Prevalence Risk Assessment Risk Factors Severity of Illness Index Surgery Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D deficiency Vitamin D Deficiency - blood Vitamin D Deficiency - diagnosis Vitamin D Deficiency - epidemiology |
| title | Vitamin D Deficiency may be an Independent Risk Factor for Arterial Disease |
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