Nursing During the First Two Days of Life Is Essential for the Expression of Proteins Important for Growth and Remodeling of the Neonatal Porcine Cervix
The neonatal porcine cervix is sensitive to hormones, including relaxin (RLX), from birth. Whether nursing is required to establish the cervical developmental program or to determine cervical developmental trajectory is unknown. The objective of study 1 was to determine effects of age and nursing on...
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| Veröffentlicht in: | Endocrinology (Philadelphia) 2012-09, Vol.153 (9), p.4511-4521 |
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| creator | Frankshun, Amy-Lynn Chen, Joseph Barron, Lauren A Ho, Teh-Yuan Miller, Dori J Rahman, Kathleen M Bartol, Frank F Bagnell, Carol A |
| description | The neonatal porcine cervix is sensitive to hormones, including relaxin (RLX), from birth. Whether nursing is required to establish the cervical developmental program or to determine cervical developmental trajectory is unknown. The objective of study 1 was to determine effects of age and nursing on expression of molecular markers and mediators of porcine cervical growth and remodeling from birth to postnatal day (PND) 2 and to document effects of RLX treatment during this period on expression of targeted gene products in nursed vs. replacer-fed gilts. Study 2 was conducted to determine effects of age at first nursing and duration of nursing from birth on expression of targeted transcripts or proteins at PND 14. Nursing supported cervical estrogen receptor-α, vascular endothelial growth factor, matrix metalloproteinase (MMP)9, and antiapoptotic B-cell lymphoma-2 protein expression on PND 2. These proteins were undetectable in replacer-fed gilts. Returning replacer-fed gilts to nursing after PND 2 did not restore cervical expression of these proteins by PND 14. RLX increased (P < 0.05) cervical estrogen receptor-α, vascular endothelial growth factor, and B-cell lymphoma-2 protein in nursed gilts, MMP2 protein in nursed and replacer-fed gilts, and decreased (P < 0.05) pro-MMP9 protein in nursed gilts, and RXFP1 mRNA levels in nursed and replacer-fed gilts at PND 2. Replacer feeding for 2 wk from birth increased (P < 0.05) RXFP1 mRNA levels on PND 14. Results support the lactocrine hypothesis for maternal programming of neonatal tissues. Nursing from birth is required to establish the neonatal cervical developmental program and to maintain cervical developmental trajectory to PND 14. |
| doi_str_mv | 10.1210/en.2012-1329 |
| format | Article |
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Whether nursing is required to establish the cervical developmental program or to determine cervical developmental trajectory is unknown. The objective of study 1 was to determine effects of age and nursing on expression of molecular markers and mediators of porcine cervical growth and remodeling from birth to postnatal day (PND) 2 and to document effects of RLX treatment during this period on expression of targeted gene products in nursed vs. replacer-fed gilts. Study 2 was conducted to determine effects of age at first nursing and duration of nursing from birth on expression of targeted transcripts or proteins at PND 14. Nursing supported cervical estrogen receptor-α, vascular endothelial growth factor, matrix metalloproteinase (MMP)9, and antiapoptotic B-cell lymphoma-2 protein expression on PND 2. These proteins were undetectable in replacer-fed gilts. Returning replacer-fed gilts to nursing after PND 2 did not restore cervical expression of these proteins by PND 14. RLX increased (P < 0.05) cervical estrogen receptor-α, vascular endothelial growth factor, and B-cell lymphoma-2 protein in nursed gilts, MMP2 protein in nursed and replacer-fed gilts, and decreased (P < 0.05) pro-MMP9 protein in nursed gilts, and RXFP1 mRNA levels in nursed and replacer-fed gilts at PND 2. Replacer feeding for 2 wk from birth increased (P < 0.05) RXFP1 mRNA levels on PND 14. Results support the lactocrine hypothesis for maternal programming of neonatal tissues. Nursing from birth is required to establish the neonatal cervical developmental program and to maintain cervical developmental trajectory to PND 14.</description><identifier>ISSN: 0013-7227</identifier><identifier>EISSN: 1945-7170</identifier><identifier>DOI: 10.1210/en.2012-1329</identifier><identifier>PMID: 22778228</identifier><identifier>CODEN: ENDOAO</identifier><language>eng</language><publisher>Chevy Chase, MD: Endocrine Society</publisher><subject>Age factors ; Animals ; Animals, Newborn ; B-cell lymphoma ; Biological and medical sciences ; Birth ; Cervix ; Cervix Uteri - drug effects ; Cervix Uteri - growth & development ; Cervix Uteri - metabolism ; Estrogen Receptor alpha - metabolism ; Estrogen receptors ; Estrogens ; Female ; Fundamental and applied biological sciences. Psychology ; Gelatinase A ; Gelatinase B ; Gene Expression Regulation, Developmental ; Growth factors ; Hormones ; Immunoblotting ; Lymphocytes B ; Lymphoma ; Matrix metalloproteinase ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 9 - metabolism ; Matrix metalloproteinases ; Metalloproteinase ; Neonates ; Nursing ; Polymerase Chain Reaction ; Proteins ; Receptors ; Relaxin ; Relaxin - pharmacology ; Swine ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - metabolism ; Vertebrates: endocrinology</subject><ispartof>Endocrinology (Philadelphia), 2012-09, Vol.153 (9), p.4511-4521</ispartof><rights>Copyright © 2012 by The Endocrine Society</rights><rights>Copyright © 2012 by The Endocrine Society 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-4288a090d9ae4cbe932b78c0774928b6a3544b174690945ee3776a948011d5bd3</citedby><cites>FETCH-LOGICAL-c463t-4288a090d9ae4cbe932b78c0774928b6a3544b174690945ee3776a948011d5bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26285565$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22778228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frankshun, Amy-Lynn</creatorcontrib><creatorcontrib>Chen, Joseph</creatorcontrib><creatorcontrib>Barron, Lauren A</creatorcontrib><creatorcontrib>Ho, Teh-Yuan</creatorcontrib><creatorcontrib>Miller, Dori J</creatorcontrib><creatorcontrib>Rahman, Kathleen M</creatorcontrib><creatorcontrib>Bartol, Frank F</creatorcontrib><creatorcontrib>Bagnell, Carol A</creatorcontrib><title>Nursing During the First Two Days of Life Is Essential for the Expression of Proteins Important for Growth and Remodeling of the Neonatal Porcine Cervix</title><title>Endocrinology (Philadelphia)</title><addtitle>Endocrinology</addtitle><description>The neonatal porcine cervix is sensitive to hormones, including relaxin (RLX), from birth. Whether nursing is required to establish the cervical developmental program or to determine cervical developmental trajectory is unknown. The objective of study 1 was to determine effects of age and nursing on expression of molecular markers and mediators of porcine cervical growth and remodeling from birth to postnatal day (PND) 2 and to document effects of RLX treatment during this period on expression of targeted gene products in nursed vs. replacer-fed gilts. Study 2 was conducted to determine effects of age at first nursing and duration of nursing from birth on expression of targeted transcripts or proteins at PND 14. Nursing supported cervical estrogen receptor-α, vascular endothelial growth factor, matrix metalloproteinase (MMP)9, and antiapoptotic B-cell lymphoma-2 protein expression on PND 2. These proteins were undetectable in replacer-fed gilts. Returning replacer-fed gilts to nursing after PND 2 did not restore cervical expression of these proteins by PND 14. RLX increased (P < 0.05) cervical estrogen receptor-α, vascular endothelial growth factor, and B-cell lymphoma-2 protein in nursed gilts, MMP2 protein in nursed and replacer-fed gilts, and decreased (P < 0.05) pro-MMP9 protein in nursed gilts, and RXFP1 mRNA levels in nursed and replacer-fed gilts at PND 2. Replacer feeding for 2 wk from birth increased (P < 0.05) RXFP1 mRNA levels on PND 14. Results support the lactocrine hypothesis for maternal programming of neonatal tissues. Nursing from birth is required to establish the neonatal cervical developmental program and to maintain cervical developmental trajectory to PND 14.</description><subject>Age factors</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>B-cell lymphoma</subject><subject>Biological and medical sciences</subject><subject>Birth</subject><subject>Cervix</subject><subject>Cervix Uteri - drug effects</subject><subject>Cervix Uteri - growth & development</subject><subject>Cervix Uteri - metabolism</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>Estrogen receptors</subject><subject>Estrogens</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gelatinase A</subject><subject>Gelatinase B</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Growth factors</subject><subject>Hormones</subject><subject>Immunoblotting</subject><subject>Lymphocytes B</subject><subject>Lymphoma</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Matrix Metalloproteinase 9 - metabolism</subject><subject>Matrix metalloproteinases</subject><subject>Metalloproteinase</subject><subject>Neonates</subject><subject>Nursing</subject><subject>Polymerase Chain Reaction</subject><subject>Proteins</subject><subject>Receptors</subject><subject>Relaxin</subject><subject>Relaxin - pharmacology</subject><subject>Swine</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><subject>Vertebrates: endocrinology</subject><issn>0013-7227</issn><issn>1945-7170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctu1DAUBmALgejQsmONLKEKFqT4ljheoum0jDQqVVXWkZOcUFeJHWynlzfhcXFmBiohWFm2Pv3H9o_QG0pOKKPkE9gTRijLKGfqGVpQJfJMUkmeowUhlGeSMXmAXoVwm7ZCCP4SHaQjWTJWLtDPi8kHY7_j08nPS7wBfGZ8iPj63uFT_Riw6_DGdIDXAa9CABuN7nHn_NauHkYPIRhnZ3fpXQRjA14Po_NR27iF597dxxusbYuvYHAt9POo5OeEC3BWxxR56XxjLOAl-DvzcIRedLoP8Hq_HqJvZ6vr5Zds8_V8vfy8yRpR8JgJVpaaKNIqDaKpQXFWy7IhUgrFyrrQPBeiplIUiqSfAeBSFlqJklDa5nXLD9GHXe7o3Y8JQqwGExroe23BTaGihOeUFIVSib77i966ydt0u4pTTgrGSZkn9XGnGu9C8NBVozeD9o8pqpobq8BWc2PV3Fjib_ehUz1A-wf_riiB4z3QodF957VtTHhyBSvzvJjnvt85N43_G5ntR_KdBNu6JtUO2w6fXvPPi_4C4Z66LQ</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Frankshun, Amy-Lynn</creator><creator>Chen, Joseph</creator><creator>Barron, Lauren A</creator><creator>Ho, Teh-Yuan</creator><creator>Miller, Dori J</creator><creator>Rahman, Kathleen M</creator><creator>Bartol, Frank F</creator><creator>Bagnell, Carol A</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Nursing During the First Two Days of Life Is Essential for the Expression of Proteins Important for Growth and Remodeling of the Neonatal Porcine Cervix</title><author>Frankshun, Amy-Lynn ; Chen, Joseph ; Barron, Lauren A ; Ho, Teh-Yuan ; Miller, Dori J ; Rahman, Kathleen M ; Bartol, Frank F ; Bagnell, Carol A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-4288a090d9ae4cbe932b78c0774928b6a3544b174690945ee3776a948011d5bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age factors</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>B-cell lymphoma</topic><topic>Biological and medical sciences</topic><topic>Birth</topic><topic>Cervix</topic><topic>Cervix Uteri - drug effects</topic><topic>Cervix Uteri - growth & development</topic><topic>Cervix Uteri - metabolism</topic><topic>Estrogen Receptor alpha - metabolism</topic><topic>Estrogen receptors</topic><topic>Estrogens</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gelatinase A</topic><topic>Gelatinase B</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Growth factors</topic><topic>Hormones</topic><topic>Immunoblotting</topic><topic>Lymphocytes B</topic><topic>Lymphoma</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Matrix Metalloproteinase 9 - metabolism</topic><topic>Matrix metalloproteinases</topic><topic>Metalloproteinase</topic><topic>Neonates</topic><topic>Nursing</topic><topic>Polymerase Chain Reaction</topic><topic>Proteins</topic><topic>Receptors</topic><topic>Relaxin</topic><topic>Relaxin - pharmacology</topic><topic>Swine</topic><topic>Vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frankshun, Amy-Lynn</creatorcontrib><creatorcontrib>Chen, Joseph</creatorcontrib><creatorcontrib>Barron, Lauren A</creatorcontrib><creatorcontrib>Ho, Teh-Yuan</creatorcontrib><creatorcontrib>Miller, Dori J</creatorcontrib><creatorcontrib>Rahman, Kathleen M</creatorcontrib><creatorcontrib>Bartol, Frank F</creatorcontrib><creatorcontrib>Bagnell, Carol A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frankshun, Amy-Lynn</au><au>Chen, Joseph</au><au>Barron, Lauren A</au><au>Ho, Teh-Yuan</au><au>Miller, Dori J</au><au>Rahman, Kathleen M</au><au>Bartol, Frank F</au><au>Bagnell, Carol A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nursing During the First Two Days of Life Is Essential for the Expression of Proteins Important for Growth and Remodeling of the Neonatal Porcine Cervix</atitle><jtitle>Endocrinology (Philadelphia)</jtitle><addtitle>Endocrinology</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>153</volume><issue>9</issue><spage>4511</spage><epage>4521</epage><pages>4511-4521</pages><issn>0013-7227</issn><eissn>1945-7170</eissn><coden>ENDOAO</coden><abstract>The neonatal porcine cervix is sensitive to hormones, including relaxin (RLX), from birth. Whether nursing is required to establish the cervical developmental program or to determine cervical developmental trajectory is unknown. The objective of study 1 was to determine effects of age and nursing on expression of molecular markers and mediators of porcine cervical growth and remodeling from birth to postnatal day (PND) 2 and to document effects of RLX treatment during this period on expression of targeted gene products in nursed vs. replacer-fed gilts. Study 2 was conducted to determine effects of age at first nursing and duration of nursing from birth on expression of targeted transcripts or proteins at PND 14. Nursing supported cervical estrogen receptor-α, vascular endothelial growth factor, matrix metalloproteinase (MMP)9, and antiapoptotic B-cell lymphoma-2 protein expression on PND 2. These proteins were undetectable in replacer-fed gilts. Returning replacer-fed gilts to nursing after PND 2 did not restore cervical expression of these proteins by PND 14. RLX increased (P < 0.05) cervical estrogen receptor-α, vascular endothelial growth factor, and B-cell lymphoma-2 protein in nursed gilts, MMP2 protein in nursed and replacer-fed gilts, and decreased (P < 0.05) pro-MMP9 protein in nursed gilts, and RXFP1 mRNA levels in nursed and replacer-fed gilts at PND 2. Replacer feeding for 2 wk from birth increased (P < 0.05) RXFP1 mRNA levels on PND 14. Results support the lactocrine hypothesis for maternal programming of neonatal tissues. Nursing from birth is required to establish the neonatal cervical developmental program and to maintain cervical developmental trajectory to PND 14.</abstract><cop>Chevy Chase, MD</cop><pub>Endocrine Society</pub><pmid>22778228</pmid><doi>10.1210/en.2012-1329</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Journals@Ovid Ovid Autoload; OUP_牛津大学出版社现刊; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Age factors Animals Animals, Newborn B-cell lymphoma Biological and medical sciences Birth Cervix Cervix Uteri - drug effects Cervix Uteri - growth & development Cervix Uteri - metabolism Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Female Fundamental and applied biological sciences. Psychology Gelatinase A Gelatinase B Gene Expression Regulation, Developmental Growth factors Hormones Immunoblotting Lymphocytes B Lymphoma Matrix metalloproteinase Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Matrix metalloproteinases Metalloproteinase Neonates Nursing Polymerase Chain Reaction Proteins Receptors Relaxin Relaxin - pharmacology Swine Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vertebrates: endocrinology |
| title | Nursing During the First Two Days of Life Is Essential for the Expression of Proteins Important for Growth and Remodeling of the Neonatal Porcine Cervix |
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