Effect of Influenza Vaccination in the First Trimester of Pregnancy
To estimate the effect of first-trimester influenza vaccination on fetal and neonatal outcomes. This was a retrospective cohort study examining delivery and neonatal outcomes after antepartum exposure to the seasonal trivalent inactive influenza vaccine. Data were collected and entered into an estab...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2012-09, Vol.120 (3), p.532-537 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Sheffield, Jeanne S. Greer, Laura G. Rogers, Vanessa L. Roberts, Scott W. Lytle, Heather McIntire, Donald D. Wendel, George D. |
| description | To estimate the effect of first-trimester influenza vaccination on fetal and neonatal outcomes.
This was a retrospective cohort study examining delivery and neonatal outcomes after antepartum exposure to the seasonal trivalent inactive influenza vaccine. Data were collected and entered into an established computerized database. Outcomes by trimester of vaccination were then compared with women who did not receive the vaccine.
During the 5-year study period, 10,225 women received the seasonal influenza vaccine antepartum; 8,690 of these delivered at our institution, 439 in the first trimester and 8,251 in the second and third trimesters. Women vaccinated antepartum were significantly older with higher parity than women who declined vaccination. Neonates born to mothers receiving the vaccine in any trimester did not have an increase in major malformations regardless of trimester of vaccination (2% regardless of vaccination group, P=.9). Stillbirth (0.3% compared with 0.6%, P=.006), neonatal death (0.2% compared with 0.4%, P=.01), and premature delivery (5% compared with 6%, P=.004) were significantly decreased in the vaccinated group.
Influenza vaccination in the first trimester was not associated with an increase in major malformation rates and was associated with a decrease in the overall stillbirth rate. This information will aid in counseling women regarding the safety of influenza vaccination in the first trimester. |
| doi_str_mv | 10.1097/AOG.0b013e318263a278 |
| format | Article |
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This was a retrospective cohort study examining delivery and neonatal outcomes after antepartum exposure to the seasonal trivalent inactive influenza vaccine. Data were collected and entered into an established computerized database. Outcomes by trimester of vaccination were then compared with women who did not receive the vaccine.
During the 5-year study period, 10,225 women received the seasonal influenza vaccine antepartum; 8,690 of these delivered at our institution, 439 in the first trimester and 8,251 in the second and third trimesters. Women vaccinated antepartum were significantly older with higher parity than women who declined vaccination. Neonates born to mothers receiving the vaccine in any trimester did not have an increase in major malformations regardless of trimester of vaccination (2% regardless of vaccination group, P=.9). Stillbirth (0.3% compared with 0.6%, P=.006), neonatal death (0.2% compared with 0.4%, P=.01), and premature delivery (5% compared with 6%, P=.004) were significantly decreased in the vaccinated group.
Influenza vaccination in the first trimester was not associated with an increase in major malformation rates and was associated with a decrease in the overall stillbirth rate. This information will aid in counseling women regarding the safety of influenza vaccination in the first trimester.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/AOG.0b013e318263a278</identifier><identifier>PMID: 22914461</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>Hagerstown, MD: by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cohort Studies ; Congenital Abnormalities - etiology ; Female ; Gynecology. Andrology. Obstetrics ; Human viral diseases ; Humans ; Infant Mortality ; Infant, Newborn ; Infectious diseases ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - adverse effects ; Influenza, Human - prevention & control ; Medical sciences ; Pregnancy ; Pregnancy Complications, Infectious - prevention & control ; Pregnancy Outcome ; Pregnancy Trimester, First ; Pregnancy Trimester, Second ; Pregnancy Trimester, Third ; Premature Birth - etiology ; Premature Birth - prevention & control ; Prenatal Care ; Retrospective Studies ; Stillbirth ; Vaccines, Inactivated - administration & dosage ; Vaccines, Inactivated - adverse effects ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases ; Young Adult</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2012-09, Vol.120 (3), p.532-537</ispartof><rights>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3826-a3d7aa0d4c72328c2491bcda0b6dc7871a9d21955b4d361c0e805c8bcf2b3f8a3</citedby><cites>FETCH-LOGICAL-c3826-a3d7aa0d4c72328c2491bcda0b6dc7871a9d21955b4d361c0e805c8bcf2b3f8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26281169$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22914461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheffield, Jeanne S.</creatorcontrib><creatorcontrib>Greer, Laura G.</creatorcontrib><creatorcontrib>Rogers, Vanessa L.</creatorcontrib><creatorcontrib>Roberts, Scott W.</creatorcontrib><creatorcontrib>Lytle, Heather</creatorcontrib><creatorcontrib>McIntire, Donald D.</creatorcontrib><creatorcontrib>Wendel, George D.</creatorcontrib><title>Effect of Influenza Vaccination in the First Trimester of Pregnancy</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>To estimate the effect of first-trimester influenza vaccination on fetal and neonatal outcomes.
This was a retrospective cohort study examining delivery and neonatal outcomes after antepartum exposure to the seasonal trivalent inactive influenza vaccine. Data were collected and entered into an established computerized database. Outcomes by trimester of vaccination were then compared with women who did not receive the vaccine.
During the 5-year study period, 10,225 women received the seasonal influenza vaccine antepartum; 8,690 of these delivered at our institution, 439 in the first trimester and 8,251 in the second and third trimesters. Women vaccinated antepartum were significantly older with higher parity than women who declined vaccination. Neonates born to mothers receiving the vaccine in any trimester did not have an increase in major malformations regardless of trimester of vaccination (2% regardless of vaccination group, P=.9). Stillbirth (0.3% compared with 0.6%, P=.006), neonatal death (0.2% compared with 0.4%, P=.01), and premature delivery (5% compared with 6%, P=.004) were significantly decreased in the vaccinated group.
Influenza vaccination in the first trimester was not associated with an increase in major malformation rates and was associated with a decrease in the overall stillbirth rate. This information will aid in counseling women regarding the safety of influenza vaccination in the first trimester.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Congenital Abnormalities - etiology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant Mortality</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - adverse effects</subject><subject>Influenza, Human - prevention & control</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - prevention & control</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy Trimester, Third</subject><subject>Premature Birth - etiology</subject><subject>Premature Birth - prevention & control</subject><subject>Prenatal Care</subject><subject>Retrospective Studies</subject><subject>Stillbirth</subject><subject>Vaccines, Inactivated - administration & dosage</subject><subject>Vaccines, Inactivated - adverse effects</subject><subject>Viral diseases</subject><subject>Viral diseases of the respiratory system and ent viral diseases</subject><subject>Young Adult</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1LxDAQhoMo7rr6D0R6EbxUZ5K0TY_Lsn6AoAcVb2WaJm6122rSIvrrzeq6gqcw4ZmZN08YO0Q4Rcizs-nNxSmUgMIIVDwVxDO1xcaoMhFzIR632RiA53GmpByxPe-fAQDTXOyyEec5SpnimM3m1hrdR52NrlrbDKb9pOiBtK5b6uuujeo26hcmOq-d76M7Vy-N741b8bfOPLXU6o99tmOp8eZgfU7Y_fn8bnYZX99cXM2m17EWIWBMosqIoJI644IrzWWOpa4IyrTSmcqQ8opjniSlrESKGoyCRKtSW14Kq0hM2MnP3FfXvQ0hR7GsvTZNQ63pBl8giARBJhIDKn9Q7TrvnbHFa4hO7iNAxUpfEfQV__WFtqP1hqFcmmrT9OsrAMdrgLymxrrw_tr_cSlXuHK82f_eNUGXf2mGd-OKhaGmXxThIyDlCcQckEMeqvj7SnwB5xqHfQ</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Sheffield, Jeanne S.</creator><creator>Greer, Laura G.</creator><creator>Rogers, Vanessa L.</creator><creator>Roberts, Scott W.</creator><creator>Lytle, Heather</creator><creator>McIntire, Donald D.</creator><creator>Wendel, George D.</creator><general>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Effect of Influenza Vaccination in the First Trimester of Pregnancy</title><author>Sheffield, Jeanne S. ; Greer, Laura G. ; Rogers, Vanessa L. ; Roberts, Scott W. ; Lytle, Heather ; McIntire, Donald D. ; Wendel, George D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3826-a3d7aa0d4c72328c2491bcda0b6dc7871a9d21955b4d361c0e805c8bcf2b3f8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Congenital Abnormalities - etiology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant Mortality</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Influenza Vaccines - administration & dosage</topic><topic>Influenza Vaccines - adverse effects</topic><topic>Influenza, Human - prevention & control</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - prevention & control</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy Trimester, Third</topic><topic>Premature Birth - etiology</topic><topic>Premature Birth - prevention & control</topic><topic>Prenatal Care</topic><topic>Retrospective Studies</topic><topic>Stillbirth</topic><topic>Vaccines, Inactivated - administration & dosage</topic><topic>Vaccines, Inactivated - adverse effects</topic><topic>Viral diseases</topic><topic>Viral diseases of the respiratory system and ent viral diseases</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheffield, Jeanne S.</creatorcontrib><creatorcontrib>Greer, Laura G.</creatorcontrib><creatorcontrib>Rogers, Vanessa L.</creatorcontrib><creatorcontrib>Roberts, Scott W.</creatorcontrib><creatorcontrib>Lytle, Heather</creatorcontrib><creatorcontrib>McIntire, Donald D.</creatorcontrib><creatorcontrib>Wendel, George D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheffield, Jeanne S.</au><au>Greer, Laura G.</au><au>Rogers, Vanessa L.</au><au>Roberts, Scott W.</au><au>Lytle, Heather</au><au>McIntire, Donald D.</au><au>Wendel, George D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Influenza Vaccination in the First Trimester of Pregnancy</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>120</volume><issue>3</issue><spage>532</spage><epage>537</epage><pages>532-537</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>To estimate the effect of first-trimester influenza vaccination on fetal and neonatal outcomes.
This was a retrospective cohort study examining delivery and neonatal outcomes after antepartum exposure to the seasonal trivalent inactive influenza vaccine. Data were collected and entered into an established computerized database. Outcomes by trimester of vaccination were then compared with women who did not receive the vaccine.
During the 5-year study period, 10,225 women received the seasonal influenza vaccine antepartum; 8,690 of these delivered at our institution, 439 in the first trimester and 8,251 in the second and third trimesters. Women vaccinated antepartum were significantly older with higher parity than women who declined vaccination. Neonates born to mothers receiving the vaccine in any trimester did not have an increase in major malformations regardless of trimester of vaccination (2% regardless of vaccination group, P=.9). Stillbirth (0.3% compared with 0.6%, P=.006), neonatal death (0.2% compared with 0.4%, P=.01), and premature delivery (5% compared with 6%, P=.004) were significantly decreased in the vaccinated group.
Influenza vaccination in the first trimester was not associated with an increase in major malformation rates and was associated with a decrease in the overall stillbirth rate. This information will aid in counseling women regarding the safety of influenza vaccination in the first trimester.</abstract><cop>Hagerstown, MD</cop><pub>by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>22914461</pmid><doi>10.1097/AOG.0b013e318263a278</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 2012-09, Vol.120 (3), p.532-537 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Biological and medical sciences Cohort Studies Congenital Abnormalities - etiology Female Gynecology. Andrology. Obstetrics Human viral diseases Humans Infant Mortality Infant, Newborn Infectious diseases Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza, Human - prevention & control Medical sciences Pregnancy Pregnancy Complications, Infectious - prevention & control Pregnancy Outcome Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy Trimester, Third Premature Birth - etiology Premature Birth - prevention & control Prenatal Care Retrospective Studies Stillbirth Vaccines, Inactivated - administration & dosage Vaccines, Inactivated - adverse effects Viral diseases Viral diseases of the respiratory system and ent viral diseases Young Adult |
| title | Effect of Influenza Vaccination in the First Trimester of Pregnancy |
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