Nonesterified fatty acids modify inflammatory response and eicosanoid biosynthesis in bovine endothelial cells

Intense lipid mobilization during the transition period in dairy cows is associated with increased disease susceptibility. The potential impact of altered plasma nonesterified fatty acids (NEFA) concentrations and composition on host inflammatory responses that may contribute to disease incidence an...

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Veröffentlicht in:	Journal of dairy science 2012-09, Vol.95 (9), p.5011-5023
Hauptverfasser:	Contreras, G.A., Raphael, W., Mattmiller, S.A., Gandy, J., Sordillo, L.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Animal productions Animals arachidonic acid Biological and medical sciences biosynthesis Blotting, Western - veterinary Cattle Cells, Cultured Cyclooxygenase 2 - metabolism cytokines dairy cows disease incidence disease resistance Dose-Response Relationship, Drug eicosanoids Eicosanoids - analysis Eicosanoids - biosynthesis endometritis endothelial cell endothelial cells Endothelium, Vascular - chemistry Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism fatty acid composition Fatty Acids, Nonesterified - pharmacology Female Flow Cytometry Food industries free fatty acids Fundamental and applied biological sciences. Psychology gene expression inflammation Inflammation - metabolism Inflammation - physiopathology lactation lipid mobilization long chain polyunsaturated fatty acids mastitis messenger RNA Milk and cheese industries. Ice creams nonesterified fatty acid pathogenesis phenotype Polymerase Chain Reaction - veterinary prostaglandin synthase Reactive Oxygen Species - analysis stearic acid Terrestrial animal productions transition period Vertebrates
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