Purification and characterization of Hb 98–114: A novel hemoglobin-derived antimicrobial peptide from the midgut of Rhipicephalus (Boophilus) microplus

► A new antimicrobial peptide was identified in the tick Ripicephalus microplus. ► This peptide is originated from bovine hemoglobin α-chain amino acids 98–114. ► Synthetic Hb 98–114 permeabilized Candida albicans cells and had fungicidal effect. ► Hb 98–114 has α-helix structure only in the presenc...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2012-09, Vol.37 (1), p.120-127
Hauptverfasser:	Belmonte, Rodrigo, Cruz, Carlos E., Pires, José R., Daffre, Sirlei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha helical peptides Amino Acid Sequence Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antimicrobial peptides Cattle Cell Membrane - drug effects Cell Membrane - metabolism Chromatography, High Pressure Liquid Chromatography, Reverse-Phase Enterobacteriaceae - drug effects Female Fluorescent Dyes - metabolism Gastrointestinal Tract - chemistry Gram-Positive Endospore-Forming Rods - drug effects Hemoglobin digestion Hemoglobins - chemistry Hemoglobins - isolation & purification Hemoglobins - pharmacology Membrane permeabilization Microbial Sensitivity Tests Mitosporic Fungi - drug effects Mitosporic Fungi - metabolism Models, Molecular Molecular Sequence Data Peptide Fragments - chemistry Peptide Fragments - isolation & purification Peptide Fragments - pharmacology Permeability Protein Structure, Secondary Pseudomonas aeruginosa - drug effects Rhipicephalus Rhipicephalus (Boophilus) microplus
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