Portal Vein Embolisation for Extended Hepatectomy: Single-Centre Experience
Background Portal vein embolisation (PVE) induces contra-lateral liver hypertrophy to facilitate an extended hepatectomy. Aim This paper aims to analyse our data on PVE and extended hepatectomy. Outcome measures included success of PVE, feasibility of resections, operative morbidity and survival. Me...
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| Veröffentlicht in: | Journal of gastrointestinal cancer 2012-09, Vol.43 (3), p.413-419 |
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| container_title | Journal of gastrointestinal cancer |
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| creator | Vyas, Soumil Bent, Clare Partelli, Stefano Abraham, Ajit T. Hutchins, Robert R. Bhattacharya, Satyajit Low, Deborah Fotheringham, Tim Kocher, Hemant M. |
| description | Background
Portal vein embolisation (PVE) induces contra-lateral liver hypertrophy to facilitate an extended hepatectomy.
Aim
This paper aims to analyse our data on PVE and extended hepatectomy. Outcome measures included success of PVE, feasibility of resections, operative morbidity and survival.
Methods
A retrospective analysis of data collected prospectively on 33 patients (2004–2008) was performed. Survival curves were estimated by the Kaplan–Meier (Breslow) method. Significance was defined as
p
|
| doi_str_mv | 10.1007/s12029-011-9321-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1035102308</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1035102308</sourcerecordid><originalsourceid>FETCH-LOGICAL-c211x-9a08ab0e3d8a3931440f6fc8347278113b2e009b1c481dbf3101d01ae182ab13</originalsourceid><addsrcrecordid>eNp9kMFKw0AQhhdRbK0-gBfJ0Ut0ZjdNN96kVCsWFCxel00yKSnJbt1NoH17t7T26GkG5vt_mI-xW4QHBJg8euTAsxgQ40xwjLdnbIhZgnGaivT8tHM5YFferwHSZIx4yQY8XCSfwJC9f1rX6Sb6ptpEsza3Te11V1sTVdZFs21HpqQymtNGd1R0tt09RV-1WTUUT8l0jgKzIVeTKeiaXVS68XRznCO2fJktp_N48fH6Nn1exAVH3MaZBqlzIFFKLTKBSQJVWhVSJBM-kYgi5wSQ5VgkEsu8EghYAmpCyXWOYsTuD7UbZ3968p1qa19Q02hDtvcKQYwRuAAZUDyghbPeO6rUxtWtdrsAqb1CdVCogkK1V6i2IXN3rO_zlspT4s9ZAPgB8OFkVuTU2vbOhI__af0FATR7hw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1035102308</pqid></control><display><type>article</type><title>Portal Vein Embolisation for Extended Hepatectomy: Single-Centre Experience</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Vyas, Soumil ; Bent, Clare ; Partelli, Stefano ; Abraham, Ajit T. ; Hutchins, Robert R. ; Bhattacharya, Satyajit ; Low, Deborah ; Fotheringham, Tim ; Kocher, Hemant M.</creator><creatorcontrib>Vyas, Soumil ; Bent, Clare ; Partelli, Stefano ; Abraham, Ajit T. ; Hutchins, Robert R. ; Bhattacharya, Satyajit ; Low, Deborah ; Fotheringham, Tim ; Kocher, Hemant M.</creatorcontrib><description>Background
Portal vein embolisation (PVE) induces contra-lateral liver hypertrophy to facilitate an extended hepatectomy.
Aim
This paper aims to analyse our data on PVE and extended hepatectomy. Outcome measures included success of PVE, feasibility of resections, operative morbidity and survival.
Methods
A retrospective analysis of data collected prospectively on 33 patients (2004–2008) was performed. Survival curves were estimated by the Kaplan–Meier (Breslow) method. Significance was defined as
p
< 0.05.
Results
A total of 31 patients had successful PVE. There were 24 patients who underwent surgery. Significant hypertrophy of residual liver was noted from 230.15 (pre-embolisation) to 428.50 ml (post-embolisation) (median,
p
< 0.0001). A total of 16 patients had hepatectomy (14: R0; 2: R1) with a single mortality (6.25%) and 56.25% morbidity, and a median length of stay of 17 days. Median overall survival was 14 (95% CI 7.8–20.2) months. Patients who underwent resection had a median disease-specific survival of 33 (95% CI 4–62) months compared with 8.6 (95% CI 0–19.9) months for patients without resection (
p
= 0.14). For patients with primary hepato-biliary tumours, the median disease-specific survival was 7.9 (95% CI 4.5–11.3) months compared with a median survival of 19.7 (95% CI 0–42.2) months for patients with metastases (
p
= 0.07).
Conclusions
PVE is safe, facilitates R0 resection and offers the best chance of cure, especially for liver metastases.</description><identifier>ISSN: 1941-6628</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-011-9321-x</identifier><identifier>PMID: 21948270</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Cancer Research ; Embolization, Therapeutic ; Female ; Gastroenterology ; Hepatectomy ; Humans ; Internal Medicine ; Liver Neoplasms - mortality ; Liver Neoplasms - secondary ; Liver Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms - mortality ; Neoplasms - pathology ; Neoplasms - surgery ; Oncology ; Original Article ; Portal Vein ; Prospective Studies ; Radiotherapy ; Retrospective Studies ; Survival Rate ; Treatment Outcome</subject><ispartof>Journal of gastrointestinal cancer, 2012-09, Vol.43 (3), p.413-419</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c211x-9a08ab0e3d8a3931440f6fc8347278113b2e009b1c481dbf3101d01ae182ab13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-011-9321-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-011-9321-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21948270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vyas, Soumil</creatorcontrib><creatorcontrib>Bent, Clare</creatorcontrib><creatorcontrib>Partelli, Stefano</creatorcontrib><creatorcontrib>Abraham, Ajit T.</creatorcontrib><creatorcontrib>Hutchins, Robert R.</creatorcontrib><creatorcontrib>Bhattacharya, Satyajit</creatorcontrib><creatorcontrib>Low, Deborah</creatorcontrib><creatorcontrib>Fotheringham, Tim</creatorcontrib><creatorcontrib>Kocher, Hemant M.</creatorcontrib><title>Portal Vein Embolisation for Extended Hepatectomy: Single-Centre Experience</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Background
Portal vein embolisation (PVE) induces contra-lateral liver hypertrophy to facilitate an extended hepatectomy.
Aim
This paper aims to analyse our data on PVE and extended hepatectomy. Outcome measures included success of PVE, feasibility of resections, operative morbidity and survival.
Methods
A retrospective analysis of data collected prospectively on 33 patients (2004–2008) was performed. Survival curves were estimated by the Kaplan–Meier (Breslow) method. Significance was defined as
p
< 0.05.
Results
A total of 31 patients had successful PVE. There were 24 patients who underwent surgery. Significant hypertrophy of residual liver was noted from 230.15 (pre-embolisation) to 428.50 ml (post-embolisation) (median,
p
< 0.0001). A total of 16 patients had hepatectomy (14: R0; 2: R1) with a single mortality (6.25%) and 56.25% morbidity, and a median length of stay of 17 days. Median overall survival was 14 (95% CI 7.8–20.2) months. Patients who underwent resection had a median disease-specific survival of 33 (95% CI 4–62) months compared with 8.6 (95% CI 0–19.9) months for patients without resection (
p
= 0.14). For patients with primary hepato-biliary tumours, the median disease-specific survival was 7.9 (95% CI 4.5–11.3) months compared with a median survival of 19.7 (95% CI 0–42.2) months for patients with metastases (
p
= 0.07).
Conclusions
PVE is safe, facilitates R0 resection and offers the best chance of cure, especially for liver metastases.</description><subject>Cancer Research</subject><subject>Embolization, Therapeutic</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - secondary</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - surgery</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Portal Vein</subject><subject>Prospective Studies</subject><subject>Radiotherapy</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>1941-6628</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKw0AQhhdRbK0-gBfJ0Ut0ZjdNN96kVCsWFCxel00yKSnJbt1NoH17t7T26GkG5vt_mI-xW4QHBJg8euTAsxgQ40xwjLdnbIhZgnGaivT8tHM5YFferwHSZIx4yQY8XCSfwJC9f1rX6Sb6ptpEsza3Te11V1sTVdZFs21HpqQymtNGd1R0tt09RV-1WTUUT8l0jgKzIVeTKeiaXVS68XRznCO2fJktp_N48fH6Nn1exAVH3MaZBqlzIFFKLTKBSQJVWhVSJBM-kYgi5wSQ5VgkEsu8EghYAmpCyXWOYsTuD7UbZ3968p1qa19Q02hDtvcKQYwRuAAZUDyghbPeO6rUxtWtdrsAqb1CdVCogkK1V6i2IXN3rO_zlspT4s9ZAPgB8OFkVuTU2vbOhI__af0FATR7hw</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Vyas, Soumil</creator><creator>Bent, Clare</creator><creator>Partelli, Stefano</creator><creator>Abraham, Ajit T.</creator><creator>Hutchins, Robert R.</creator><creator>Bhattacharya, Satyajit</creator><creator>Low, Deborah</creator><creator>Fotheringham, Tim</creator><creator>Kocher, Hemant M.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>Portal Vein Embolisation for Extended Hepatectomy: Single-Centre Experience</title><author>Vyas, Soumil ; Bent, Clare ; Partelli, Stefano ; Abraham, Ajit T. ; Hutchins, Robert R. ; Bhattacharya, Satyajit ; Low, Deborah ; Fotheringham, Tim ; Kocher, Hemant M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c211x-9a08ab0e3d8a3931440f6fc8347278113b2e009b1c481dbf3101d01ae182ab13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Cancer Research</topic><topic>Embolization, Therapeutic</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - secondary</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasms - mortality</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - surgery</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Portal Vein</topic><topic>Prospective Studies</topic><topic>Radiotherapy</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vyas, Soumil</creatorcontrib><creatorcontrib>Bent, Clare</creatorcontrib><creatorcontrib>Partelli, Stefano</creatorcontrib><creatorcontrib>Abraham, Ajit T.</creatorcontrib><creatorcontrib>Hutchins, Robert R.</creatorcontrib><creatorcontrib>Bhattacharya, Satyajit</creatorcontrib><creatorcontrib>Low, Deborah</creatorcontrib><creatorcontrib>Fotheringham, Tim</creatorcontrib><creatorcontrib>Kocher, Hemant M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vyas, Soumil</au><au>Bent, Clare</au><au>Partelli, Stefano</au><au>Abraham, Ajit T.</au><au>Hutchins, Robert R.</au><au>Bhattacharya, Satyajit</au><au>Low, Deborah</au><au>Fotheringham, Tim</au><au>Kocher, Hemant M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Portal Vein Embolisation for Extended Hepatectomy: Single-Centre Experience</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2012-09</date><risdate>2012</risdate><volume>43</volume><issue>3</issue><spage>413</spage><epage>419</epage><pages>413-419</pages><issn>1941-6628</issn><eissn>1941-6636</eissn><abstract>Background
Portal vein embolisation (PVE) induces contra-lateral liver hypertrophy to facilitate an extended hepatectomy.
Aim
This paper aims to analyse our data on PVE and extended hepatectomy. Outcome measures included success of PVE, feasibility of resections, operative morbidity and survival.
Methods
A retrospective analysis of data collected prospectively on 33 patients (2004–2008) was performed. Survival curves were estimated by the Kaplan–Meier (Breslow) method. Significance was defined as
p
< 0.05.
Results
A total of 31 patients had successful PVE. There were 24 patients who underwent surgery. Significant hypertrophy of residual liver was noted from 230.15 (pre-embolisation) to 428.50 ml (post-embolisation) (median,
p
< 0.0001). A total of 16 patients had hepatectomy (14: R0; 2: R1) with a single mortality (6.25%) and 56.25% morbidity, and a median length of stay of 17 days. Median overall survival was 14 (95% CI 7.8–20.2) months. Patients who underwent resection had a median disease-specific survival of 33 (95% CI 4–62) months compared with 8.6 (95% CI 0–19.9) months for patients without resection (
p
= 0.14). For patients with primary hepato-biliary tumours, the median disease-specific survival was 7.9 (95% CI 4.5–11.3) months compared with a median survival of 19.7 (95% CI 0–42.2) months for patients with metastases (
p
= 0.07).
Conclusions
PVE is safe, facilitates R0 resection and offers the best chance of cure, especially for liver metastases.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21948270</pmid><doi>10.1007/s12029-011-9321-x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of gastrointestinal cancer, 2012-09, Vol.43 (3), p.413-419 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Cancer Research Embolization, Therapeutic Female Gastroenterology Hepatectomy Humans Internal Medicine Liver Neoplasms - mortality Liver Neoplasms - secondary Liver Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Neoplasms - mortality Neoplasms - pathology Neoplasms - surgery Oncology Original Article Portal Vein Prospective Studies Radiotherapy Retrospective Studies Survival Rate Treatment Outcome |
| title | Portal Vein Embolisation for Extended Hepatectomy: Single-Centre Experience |
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