IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms

Interferon regulatory factor (IRF)-2 is a transcription factor involved in type I (IFN- α/β) signaling. It has been reported that IRF-2 deficiency results in various immune dysfunctions. However, the role of IRF-2 in B-cell functions needs to be elucidated. Unlike wild-type (WT) B cells, IRF-2(-/-)...

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Veröffentlicht in:	International immunology 2012-09, Vol.24 (9), p.573-581
Hauptverfasser:	Minamino, Kento, Takahara, Kazuhiko, Adachi, Takumi, Nagaoka, Koji, Iyoda, Tomonori, Taki, Shinsuke, Inaba, Kayo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - genetics B-Lymphocytes - immunology B-Lymphocytes - transplantation Cell Differentiation - genetics Cell Proliferation Cells, Cultured Gene Expression Regulation Immunoglobulin Class Switching - genetics Immunoglobulin mu-Chains - genetics Interferon Regulatory Factor-2 - genetics Interferon Regulatory Factor-2 - metabolism Lipopolysaccharides - immunology Mice Mice, Inbred C57BL Mice, Knockout Plasma Cells - immunology Plasma Cells - transplantation Positive Regulatory Domain I-Binding Factor 1 Receptor, Interferon alpha-beta - metabolism T-Lymphocytes, Helper-Inducer - immunology Transcription Factors - genetics Transcription Factors - metabolism
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