Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41

Abstract Natural antibodies to gp41 inhibit HIV-1 replication through the recognition of two different regions, corresponding to the leucine zipper motif in the HR1 alpha-helix and to another motif within HR2 region, hosting 2F5 and 4E10 epitope. This study aimed at reproducing such protective respo...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2012-09, Vol.431 (1), p.1-11
Hauptverfasser:	Pastori, C, Tudor, D, Diomede, L, Drillet, A.S, Jegerlehner, A, Röhn, T.A, Bomsel, M, Lopalco, L
Format:	Artikel
Sprache:	eng
Schlagworte:	ADCC AIDS Vaccines - administration & dosage AIDS Vaccines - immunology Animals Bacteriophages - genetics C-Terminus Cytotoxicity Cytotoxicity Tests, Immunologic Drug Carriers - administration & dosage Epitopes Female Genetic Vectors glycoprotein gp41 gp41 HIV HIV Antibodies - blood HIV Envelope Protein gp41 - immunology HIV-1 - immunology Human immunodeficiency virus 1 Immunogenicity Immunoglobulin G Immunoglobulin G - blood Infection Infectious Disease Infectivity Leucine zipper proteins Mice Mice, Inbred BALB C Mucosa N-Terminus Neutralizing antibodies Replication Vaccination Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Vaccines, Virosome - administration & dosage Vaccines, Virosome - immunology VLP
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