Synthesis of photolabile transcription initiators and preparation of photocleavable functional RNA by transcription

Two new photolabile adenosine-containing transcription initiators with terminal thiol and amino functionalities are chemically synthesized. Transcription in the presence of the transcription initiators under the T7 phi2.5 promoter produces 5′ thiol- and amino-functionalized RNA conjugated by a photo...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-07, Vol.22 (13), p.4254-4258
Hauptverfasser:	Huang, Faqing, Shi, Yongliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - chemistry adenosine monophosphate Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - chemical synthesis Adenosine Monophosphate - chemistry Adenosine Monophosphate - pharmacology Amino groups AMP Biological and medical sciences Biotin Biotin - analogs & derivatives Biotin - chemistry Half-Life In vitro selection Kinetics Medical sciences Pharmacology. Drug treatments Photolysis Promoters Purification RNA RNA - chemistry RNA - genetics RNA - metabolism RNA biotinylation RNA caging RNA labeling RNA photocleavage Succinimides - chemistry Sulfhydryl Compounds - chemistry Thiols Transcription Transcription initiator Transcription, Genetic - drug effects Ultraviolet Rays
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