Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs

Adeno-associated viral vector 9 (AAV9) has recently been shown to penetrate the blood–brain barrier via intravascular administration, making it a good candidate for diffuse gene delivery. However, the potential side effects of systemic delivery are unknown. Intrathecal viral vector administration ma...

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Veröffentlicht in:	Gene therapy 2012-08, Vol.19 (8), p.852-859
Hauptverfasser:	Federici, T, Taub, J S, Baum, G R, Gray, S J, Grieger, J C, Matthews, K A, Handy, C R, Passini, M A, Samulski, R J, Boulis, N M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2300/1514 631/378/2632/1664 631/378/2632/1823 631/61/2300 Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Blood-brain barrier Catheters Cell Biology Dependovirus - genetics Dependoviruses Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Gene Transfer Techniques Genetic aspects Genetic Vectors Green fluorescent protein Health aspects Health. Pharmaceutical industry Hogs Human Genetics Immunohistochemistry Industrial applications and implications. Economical aspects Intravenous administration Medical sciences Motor neurons Motor Neurons - metabolism Nanotechnology Neurons original-article Physiological aspects Spinal cord Spinal Cord - cytology Swine Thorax Transduction Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vectors (Biology) Viruses
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