A designed curved DNA sequence remarkably enhances transgene expression from plasmid DNA in mouse liver

The intranuclear disposition of plasmid DNA is extremely important for transgene expression. The interactions between the plasmid DNA and the histone proteins are one of the keys for controlling the disposition. In this study, the effects of a left-handedly curved sequence (20–40 repeated A•T tracts...

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Veröffentlicht in:	Gene therapy 2012-08, Vol.19 (8), p.828-835
Hauptverfasser:	Fukunaga, S, Kanda, G, Tanase, J, Harashima, H, Ohyama, T, Kamiya, H
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/1511 631/208/199 631/337/100/1701 Analysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cell Biology Cell Nucleus - metabolism Chromatin. Chromosome Deoxyribonucleic acid Disposition DNA Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Genetic aspects Handedness Health. Pharmaceutical industry Histones Histones - metabolism Human Genetics Industrial applications and implications. Economical aspects Keys Liver Liver - metabolism Male Medical sciences Mice Mice, Inbred BALB C Molecular and cellular biology Molecular genetics Nanotechnology Nucleosomes Nucleosomes - genetics Nucleotide sequence original-article Physiological aspects Plasmids Plasmids - genetics Rodents Transcription activation Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transgenes
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