D-dopachrome tautomerase (D-DT or MIF-2): Doubling the MIF cytokine family

► D-dopachrome tautomerase (D-DT) is a MIF-like pro-inflammatory cytokine. ► D-DT binds and signals via the MIF receptor CD74 and initiates similar signaling pathways. ► D-DT is a highly sensitive biomarker for sepsis and ovarian cancer. D-dopachrome tautomerase (D-DT) is a newly described cytokine...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2012-07, Vol.59 (1), p.10-17
Hauptverfasser:	Merk, Melanie, Mitchell, Robert A., Endres, Stefan, Bucala, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive immunity Amino Acid Sequence Animal models Animals Antagonists Antibodies Autoimmune diseases Biomarker blood serum Cancer CD44 antigen CD74 Cell migration cell movement Cell surface Cell survival Conserved Sequence - genetics Cytokines Disease genes Glucocorticoids human diseases Humans Immune response Immunosuppression Inflammation Intramolecular Oxidoreductases - chemistry Intramolecular Oxidoreductases - genetics Intramolecular Oxidoreductases - metabolism Macrophage migration inhibitory factor macrophage migration inhibitory factors Macrophage Migration-Inhibitory Factors - chemistry Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - metabolism Macrophages - enzymology MAP kinase MIF mitogen-activated protein kinase Models, Molecular Molecular Sequence Data neutralization proteins Sepsis
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