Interactions of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetami d es and 1-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-3-aryl-2-yl-ureas with dopamine D2 and 5-hydroxytryptamine 5HT1A receptors

It is suggested that the ratio of dopamine D2 to 5-hydroxytryptamine 5-HT1A activity is an important parameter that determines the efficiency of antipsychotic drugs. Here we present the synthesis of N-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-phenyl}-2-aryl-2-yl-acetami d es and 1-{[2-(4-phenyl-piperazin...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-06, Vol.22 (12), p.3967-3972
Hauptverfasser:	Sukalovic, Vladimir, Ignjatovic, Djurdjica, Tovilovic, Gordana, Andric, Deana, Shakib, Kaveh, Kostic-Rajacic, Sladjana, Soskic, Vukic
Format:	Artikel
Sprache:	eng
Schlagworte:	Dopamine D2 receptors
Online-Zugang:	Volltext
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