Assessment of QT-prolonging drugs in the isolated normal and failing rabbit hearts

Lengthening of QTc is the usual signal to indicate torsadogenic potential of a therapeutic agent. The ICH S7B guideline recommends that new chemical entities should be assessed for potential of delayed ventricular repolarization in animal models. The aim of this study was to determine a feasibility...

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Veröffentlicht in:	Journal of toxicological sciences 2012/06/01, Vol.37(3), pp.455-462
Hauptverfasser:	Kijtawornrat, Anusak, Sawangkoon, Suwanakiet, Hamlin, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - physiopathology Cisapride Cisapride - therapeutic use Dofetilide Electrocardiography - methods Feasibility Studies Glucose Heart - drug effects Heart - physiopathology Heart failure Heart Failure - drug therapy Heart Failure - physiopathology In Vitro Techniques Isolated rabbit heart Male Models, Animal Phenethylamines - therapeutic use Quinidine Quinidine - therapeutic use Rabbits Safety pharmacology Sulfonamides - therapeutic use Torsades de Pointes Tromethamine
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