Immunoglobulin Treatment for Severe Childhood Epilepsy
Abstract We have used intravenous immunoglobulin to treat pediatric patients with various severe epileptic conditions. This retrospective, multicenter study comprised 64 consecutive patients treated with immunoglobulins for either epileptic encephalopathy or refractory epilepsy. The rate of full or...
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| Veröffentlicht in: | Pediatric neurology 2012-06, Vol.46 (6), p.375-381 |
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| creator | Geva-Dayan, Karen, MD Shorer, Zamir, MD Menascu, Shay, MD Linder, Ilan, MD Goldberg-Stern, Hadassah, MD Heyman, Eli, MD Lerman-Sagie, Tali, MD Ben Zeev, Bruria, MD Kramer, Uri, MD |
| description | Abstract We have used intravenous immunoglobulin to treat pediatric patients with various severe epileptic conditions. This retrospective, multicenter study comprised 64 consecutive patients treated with immunoglobulins for either epileptic encephalopathy or refractory epilepsy. The rate of full or partial improvement according to specific syndrome involved three of four patients with idiopathic West syndrome, six of 12 patients with electrical status epilepticus in sleep, eight of 19 patients with an undefined syndrome, one of three patients with Landau-Kleffner syndrome, and one of two patients with Rasmussen encephalitis. Intravenous immunoglobulins were ineffective in 10 patients with symptomatic West syndrome, nine with febrile infection-related status epilepticus, three with myoclonic astatic epilepsy, and two with Lennox-Gastaut syndrome. Nine patients (14%) demonstrated complete resolution, and 10 (15.6%) exhibited partial improvement. Of these 19 responders (29.7%), eight relapsed. Although intravenous immunoglobulin is not suitable for all cases of epilepsy, it may prove efficacious for specific epileptic syndromes, mainly idiopathic West syndrome and electrical status epilepticus during sleep. |
| doi_str_mv | 10.1016/j.pediatrneurol.2012.03.015 |
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This retrospective, multicenter study comprised 64 consecutive patients treated with immunoglobulins for either epileptic encephalopathy or refractory epilepsy. The rate of full or partial improvement according to specific syndrome involved three of four patients with idiopathic West syndrome, six of 12 patients with electrical status epilepticus in sleep, eight of 19 patients with an undefined syndrome, one of three patients with Landau-Kleffner syndrome, and one of two patients with Rasmussen encephalitis. Intravenous immunoglobulins were ineffective in 10 patients with symptomatic West syndrome, nine with febrile infection-related status epilepticus, three with myoclonic astatic epilepsy, and two with Lennox-Gastaut syndrome. Nine patients (14%) demonstrated complete resolution, and 10 (15.6%) exhibited partial improvement. Of these 19 responders (29.7%), eight relapsed. Although intravenous immunoglobulin is not suitable for all cases of epilepsy, it may prove efficacious for specific epileptic syndromes, mainly idiopathic West syndrome and electrical status epilepticus during sleep.</description><identifier>ISSN: 0887-8994</identifier><identifier>EISSN: 1873-5150</identifier><identifier>DOI: 10.1016/j.pediatrneurol.2012.03.015</identifier><identifier>PMID: 22633633</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Age Factors ; Biological and medical sciences ; Child ; Child, Preschool ; Children ; Encephalitis ; Encephalopathy ; Epilepsy ; Epilepsy - drug therapy ; Epilepsy - pathology ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Immunoglobulins ; Immunoglobulins, Intravenous - therapeutic use ; Infant ; Infant, Newborn ; Intravenous administration ; Language ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Pediatrics ; Retrospective Studies ; Severity of Illness Index ; Sleep ; Treatment Outcome</subject><ispartof>Pediatric neurology, 2012-06, Vol.46 (6), p.375-381</ispartof><rights>Elsevier Inc.</rights><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-bcf1e3b30e10186bd75a960dea7e7992f43948a5826115ef7a458ce7b36762093</citedby><cites>FETCH-LOGICAL-c501t-bcf1e3b30e10186bd75a960dea7e7992f43948a5826115ef7a458ce7b36762093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pediatrneurol.2012.03.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26003549$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22633633$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geva-Dayan, Karen, MD</creatorcontrib><creatorcontrib>Shorer, Zamir, MD</creatorcontrib><creatorcontrib>Menascu, Shay, MD</creatorcontrib><creatorcontrib>Linder, Ilan, MD</creatorcontrib><creatorcontrib>Goldberg-Stern, Hadassah, MD</creatorcontrib><creatorcontrib>Heyman, Eli, MD</creatorcontrib><creatorcontrib>Lerman-Sagie, Tali, MD</creatorcontrib><creatorcontrib>Ben Zeev, Bruria, MD</creatorcontrib><creatorcontrib>Kramer, Uri, MD</creatorcontrib><title>Immunoglobulin Treatment for Severe Childhood Epilepsy</title><title>Pediatric neurology</title><addtitle>Pediatr Neurol</addtitle><description>Abstract We have used intravenous immunoglobulin to treat pediatric patients with various severe epileptic conditions. This retrospective, multicenter study comprised 64 consecutive patients treated with immunoglobulins for either epileptic encephalopathy or refractory epilepsy. The rate of full or partial improvement according to specific syndrome involved three of four patients with idiopathic West syndrome, six of 12 patients with electrical status epilepticus in sleep, eight of 19 patients with an undefined syndrome, one of three patients with Landau-Kleffner syndrome, and one of two patients with Rasmussen encephalitis. Intravenous immunoglobulins were ineffective in 10 patients with symptomatic West syndrome, nine with febrile infection-related status epilepticus, three with myoclonic astatic epilepsy, and two with Lennox-Gastaut syndrome. Nine patients (14%) demonstrated complete resolution, and 10 (15.6%) exhibited partial improvement. Of these 19 responders (29.7%), eight relapsed. Although intravenous immunoglobulin is not suitable for all cases of epilepsy, it may prove efficacious for specific epileptic syndromes, mainly idiopathic West syndrome and electrical status epilepticus during sleep.</description><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Encephalitis</subject><subject>Encephalopathy</subject><subject>Epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - pathology</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intravenous administration</subject><subject>Language</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Sleep</subject><subject>Treatment Outcome</subject><issn>0887-8994</issn><issn>1873-5150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkFr3DAQhUVpabZJ_0IxlEIvdkaSJdkUCmHZtoFAD0nOQpbHjba25Up2YP99ZXbb0pwCAl2-92bmzRDynkJBgcrLfTFh68wcRlyC7wsGlBXAC6DiBdnQSvFcUAEvyQaqSuVVXZdn5E2MewAQNStfkzPGJOfpbYi8HoZl9D963yy9G7O7gGYecJyzzofsFh8xYLZ9cH374H2b7SbX4xQPF-RVZ_qIb0__Obn_srvbfstvvn-93l7d5FYAnfPGdhR5wwFT55VsWiVMLaFFo1DVNetKXpeVERWTlArslClFZVE1XCrJoObn5OPRdwr-14Jx1oOLFvvejOiXqCnwsmJUcfUMlCZPViqa0E9H1AYfY8BOT8ENJhwStHJS7_V_Ges1Yw1cp4yT-t2p0NIM2P7V_gk1AR9OgInW9F0wo3XxHycBuCjX4XZHDlOCjw6DjtbhaFPlgHbWrXfPbOjzEx-bVulS6Z94wLj3SxjTkjTVMWn07XoW61VQBquc8t-nkrVn</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Geva-Dayan, Karen, MD</creator><creator>Shorer, Zamir, MD</creator><creator>Menascu, Shay, MD</creator><creator>Linder, Ilan, MD</creator><creator>Goldberg-Stern, Hadassah, MD</creator><creator>Heyman, Eli, MD</creator><creator>Lerman-Sagie, Tali, MD</creator><creator>Ben Zeev, Bruria, MD</creator><creator>Kramer, Uri, MD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope></search><sort><creationdate>20120601</creationdate><title>Immunoglobulin Treatment for Severe Childhood Epilepsy</title><author>Geva-Dayan, Karen, MD ; Shorer, Zamir, MD ; Menascu, Shay, MD ; Linder, Ilan, MD ; Goldberg-Stern, Hadassah, MD ; Heyman, Eli, MD ; Lerman-Sagie, Tali, MD ; Ben Zeev, Bruria, MD ; Kramer, Uri, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-bcf1e3b30e10186bd75a960dea7e7992f43948a5826115ef7a458ce7b36762093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Encephalitis</topic><topic>Encephalopathy</topic><topic>Epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - pathology</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Intravenous administration</topic><topic>Language</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Sleep</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geva-Dayan, Karen, MD</creatorcontrib><creatorcontrib>Shorer, Zamir, MD</creatorcontrib><creatorcontrib>Menascu, Shay, MD</creatorcontrib><creatorcontrib>Linder, Ilan, MD</creatorcontrib><creatorcontrib>Goldberg-Stern, Hadassah, MD</creatorcontrib><creatorcontrib>Heyman, Eli, MD</creatorcontrib><creatorcontrib>Lerman-Sagie, Tali, MD</creatorcontrib><creatorcontrib>Ben Zeev, Bruria, MD</creatorcontrib><creatorcontrib>Kramer, Uri, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Pediatric neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geva-Dayan, Karen, MD</au><au>Shorer, Zamir, MD</au><au>Menascu, Shay, MD</au><au>Linder, Ilan, MD</au><au>Goldberg-Stern, Hadassah, MD</au><au>Heyman, Eli, MD</au><au>Lerman-Sagie, Tali, MD</au><au>Ben Zeev, Bruria, MD</au><au>Kramer, Uri, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin Treatment for Severe Childhood Epilepsy</atitle><jtitle>Pediatric neurology</jtitle><addtitle>Pediatr Neurol</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>46</volume><issue>6</issue><spage>375</spage><epage>381</epage><pages>375-381</pages><issn>0887-8994</issn><eissn>1873-5150</eissn><abstract>Abstract We have used intravenous immunoglobulin to treat pediatric patients with various severe epileptic conditions. This retrospective, multicenter study comprised 64 consecutive patients treated with immunoglobulins for either epileptic encephalopathy or refractory epilepsy. The rate of full or partial improvement according to specific syndrome involved three of four patients with idiopathic West syndrome, six of 12 patients with electrical status epilepticus in sleep, eight of 19 patients with an undefined syndrome, one of three patients with Landau-Kleffner syndrome, and one of two patients with Rasmussen encephalitis. Intravenous immunoglobulins were ineffective in 10 patients with symptomatic West syndrome, nine with febrile infection-related status epilepticus, three with myoclonic astatic epilepsy, and two with Lennox-Gastaut syndrome. Nine patients (14%) demonstrated complete resolution, and 10 (15.6%) exhibited partial improvement. Of these 19 responders (29.7%), eight relapsed. Although intravenous immunoglobulin is not suitable for all cases of epilepsy, it may prove efficacious for specific epileptic syndromes, mainly idiopathic West syndrome and electrical status epilepticus during sleep.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22633633</pmid><doi>10.1016/j.pediatrneurol.2012.03.015</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Factors Biological and medical sciences Child Child, Preschool Children Encephalitis Encephalopathy Epilepsy Epilepsy - drug therapy Epilepsy - pathology Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Infant Infant, Newborn Intravenous administration Language Male Medical sciences Nervous system (semeiology, syndromes) Neurology Pediatrics Retrospective Studies Severity of Illness Index Sleep Treatment Outcome |
| title | Immunoglobulin Treatment for Severe Childhood Epilepsy |
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