Stereotactic microdialysis of the basal ganglia in Parkinson's disease

► We present a method for the study of neurotransmitter effects during DBS. ► The value of microdialysis for analysing neurotransmitters in human brain is shown. ► We developed a method for pharmacokinetic studies of L-dopa in brain tissue. Deep brain stimulation (DBS) of the subthalamic nucleus (ST...

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Veröffentlicht in:	Journal of neuroscience methods 2012-05, Vol.207 (1), p.17-22
Hauptverfasser:	Zsigmond, Peter, Dernroth, Nezirević, Kullman, Anita, Augustinsson, Lars-Erik, Dizdar, Nil
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Basal ganglia Basal Ganglia - metabolism Brain Chromatography, High Pressure Liquid DBS Deep Brain Stimulation Dopamine Agonists - therapeutic use Electrodes Female Humans Intravenous administration L-dopa Levodopa Levodopa - analysis Levodopa - therapeutic use Liquid chromatography Male Metabolites Microdialysis Middle Aged Movement disorders Neurodegenerative diseases Neurotransmitter Neurotransmitter Agents - analysis Neurotransmitter Agents - metabolism Neurotransmitters Parkinson Disease - metabolism Parkinson Disease - therapy Parkinson's disease Pharmacokinetics Sampling Solitary tract nucleus Stereotaxic Techniques Stereotaxy subthalamic nucleus tremor Veins
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