Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer

Suet Leung, Jiangchun Xu and colleagues report exome sequencing of 22 gastric cancers. They found that genes involved in chromatin modification were commonly mutated, including ARID1A encoding an SWI/SNF chromatin-remodeling complex component that had a high rate of mutation. Gastric cancer is a het...

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Veröffentlicht in:	Nature genetics 2011-12, Vol.43 (12), p.1219-1223
Hauptverfasser:	Wang, Kai, Kan, Junsuo, Yuen, Siu Tsan, Shi, Stephanie T, Chu, Kent Man, Law, Simon, Chan, Tsun Leung, Kan, Zhengyan, Chan, Annie S Y, Tsui, Wai Yin, Lee, Siu Po, Ho, Siu Lun, Chan, Anthony K W, Cheng, Grace H W, Roberts, Peter C, Rejto, Paul A, Gibson, Neil W, Pocalyko, David J, Mao, Mao, Xu, Jiangchun, Leung, Suet Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/144/68 631/208/514/1948 692/699/67/1504/1829 Adult Aged Aged, 80 and over Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Carcinogenesis Cell Cycle Proteins - genetics Chromatin Assembly and Disassembly Confidence intervals DNA sequencing Epstein-Barr virus Exome Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Function Gene mutations Genes, Neoplasm Genetic aspects Genetic Association Studies Genetics of eukaryotes. Biological and molecular evolution Genomes Health aspects Human Genetics Humans Intercellular Junctions letter Male Medical sciences Microsatellite Instability Middle Aged Mutation Neoplasm Staging Nuclear Proteins - genetics Nucleotide sequencing Prognosis Risk factors Sequence Analysis, DNA Signal Transduction Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics Stomach Neoplasms - mortality Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transcription Factors - genetics Tumors Validation studies Young Adult
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