Rhinovirus 16ainduced IFN- alpha and IFN- beta are deficient in bronchoalveolar lavage cells in asthmatic patients

Background: Asthmatic patients have defective rhinovirus-induced IFN- beta and IFN- alpha production from bronchial epithelial cells and IFN- alpha from bronchoalveolar lavage (BAL) cells. Whether bronchoalveolar lavage cells have defective type I interferon responses to rhinovirus is unknown, as ar...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2012-06, Vol.129 (6), p.1506-1514.e6
Hauptverfasser:	Sykes, Annemarie, Edwards, Michael R, Macintyre, Jonathan, del Rosario, Ajerico, Bakhsoliani, Eteri, Trujillo-Torralbo, Maria-Belen, Kon, Onn Min, Mallia, Patrick, McHale, Mark, Johnston, Sebastian L
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptor proteins Alveoli Asthma Atopy Blood Bronchus Caspase Differentiation Enzyme-linked immunosorbent assay Epithelial cells Gene expression Interferon regulatory factor 3 Interleukin 1 Leukocytes (mononuclear) Melanoma MyD88 protein Polymerase chain reaction Respiratory tract Rhinovirus Skin tests TLR3 protein TLR7 protein Toll-like receptors
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