Evaluation of In Vivo Mutagenicity by 2,4-Diaminotoluene and 2,6-Diaminotoluene in Liver of F344 gpt delta Transgenic Rat Dosed for 28 Days: A Collaborative Study of the gpt delta Transgenic Rat Mutation Assay

The transgenic rodent (TGR) assay has been widely used to study in vivo gene mutations by chemicals or radiation; however, an optimal protocol has not yet been established to assess unknown genotoxic potential. The International Workshop on Genotoxicity Testing (IWGT) strongly recommends a repeated-...

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Veröffentlicht in:	Genes and Environment 2012, Vol.34(1), pp.25-33
Hauptverfasser:	Sui, Hajime, Ohta, Ryo, Shiragiku, Toshiyuki, Akahori, Ayaka, Suzuki, Kenichiro, Nakajima, Madoka, Hayashi, Hiroyuki, Masumura, Kenichi, Nohmi, Takehiko
Format:	Artikel
Sprache:	eng
Schlagworte:	2,4-Diaminotoluene 2,6-Diaminotoluene 28 consecutive daily treatment Assays Carcinogens Chemicals Colonies Conferences Deltas diaminotoluenes F344 gpt delta transgenic rat Genotoxicity Genotoxicity testing gpt assay Liver Mutagenicity Mutant frequency Mutation Radiation Rats Rodents Sampling
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